Alpha-fetoprotein-producing advanced colorectal cancer: a rare case report and literature review
Alpha-fetoprotein(AFP)-producing colorectal cancer is a rare form of colorectal cancer with a high degree of malignancy, advanced stage, strong invasiveness, poor response to treatment, rapid progression, and poor prognosis. Herein, we present the case of a middle-aged (in his 50s) male patient who...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-08-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605221117218 |
| _version_ | 1828355727936192512 |
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| author | Huan Ding Shan Xu Kang Wang Xin Wang Guanxing Sun Xiang Li Yancui Ran Jinjun Sun |
| author_facet | Huan Ding Shan Xu Kang Wang Xin Wang Guanxing Sun Xiang Li Yancui Ran Jinjun Sun |
| author_sort | Huan Ding |
| collection | DOAJ |
| description | Alpha-fetoprotein(AFP)-producing colorectal cancer is a rare form of colorectal cancer with a high degree of malignancy, advanced stage, strong invasiveness, poor response to treatment, rapid progression, and poor prognosis. Herein, we present the case of a middle-aged (in his 50s) male patient who underwent left neck lymph node biopsy due to “left neck lymph node enlargement for 5 months.” Biopsy results revealed metastatic adenocarcinoma, and computed tomography examination of the chest and abdomen suggested a malignant tumor of the sigmoid colon with multiple metastases. Subsequently, the patient underwent colonoscopy, and the pathological result was colonic adenocarcinoma. Regarding tumor markers, serum alpha-fetoprotein (AFP) was 214 ng/mL. The patient received first- and second-line treatments for colon cancer, but progression-free survival was short. AFP was consistently elevated; after 8 months, the patient had AFP levels of 11,371.8 ng/mL, and imaging confirmed disease progression. The patient subsequently died, with an overall survival of more than 9 months. Compared with other tumor markers, AFP better reflects tumor progression in AFP-producing colorectal cancer. |
| first_indexed | 2024-04-14T02:47:14Z |
| format | Article |
| id | doaj.art-abb64a7f992d4477b220930dba37b1b0 |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-04-14T02:47:14Z |
| publishDate | 2022-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-abb64a7f992d4477b220930dba37b1b02022-12-22T02:16:29ZengSAGE PublishingJournal of International Medical Research1473-23002022-08-015010.1177/03000605221117218Alpha-fetoprotein-producing advanced colorectal cancer: a rare case report and literature reviewHuan DingShan XuKang WangXin WangGuanxing SunXiang LiYancui RanJinjun SunAlpha-fetoprotein(AFP)-producing colorectal cancer is a rare form of colorectal cancer with a high degree of malignancy, advanced stage, strong invasiveness, poor response to treatment, rapid progression, and poor prognosis. Herein, we present the case of a middle-aged (in his 50s) male patient who underwent left neck lymph node biopsy due to “left neck lymph node enlargement for 5 months.” Biopsy results revealed metastatic adenocarcinoma, and computed tomography examination of the chest and abdomen suggested a malignant tumor of the sigmoid colon with multiple metastases. Subsequently, the patient underwent colonoscopy, and the pathological result was colonic adenocarcinoma. Regarding tumor markers, serum alpha-fetoprotein (AFP) was 214 ng/mL. The patient received first- and second-line treatments for colon cancer, but progression-free survival was short. AFP was consistently elevated; after 8 months, the patient had AFP levels of 11,371.8 ng/mL, and imaging confirmed disease progression. The patient subsequently died, with an overall survival of more than 9 months. Compared with other tumor markers, AFP better reflects tumor progression in AFP-producing colorectal cancer.https://doi.org/10.1177/03000605221117218 |
| spellingShingle | Huan Ding Shan Xu Kang Wang Xin Wang Guanxing Sun Xiang Li Yancui Ran Jinjun Sun Alpha-fetoprotein-producing advanced colorectal cancer: a rare case report and literature review Journal of International Medical Research |
| title | Alpha-fetoprotein-producing advanced colorectal cancer: a rare case report and literature review |
| title_full | Alpha-fetoprotein-producing advanced colorectal cancer: a rare case report and literature review |
| title_fullStr | Alpha-fetoprotein-producing advanced colorectal cancer: a rare case report and literature review |
| title_full_unstemmed | Alpha-fetoprotein-producing advanced colorectal cancer: a rare case report and literature review |
| title_short | Alpha-fetoprotein-producing advanced colorectal cancer: a rare case report and literature review |
| title_sort | alpha fetoprotein producing advanced colorectal cancer a rare case report and literature review |
| url | https://doi.org/10.1177/03000605221117218 |
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