Traversing the cascade: urgent research priorities for implementing the ‘treat all’ strategy for children and adolescents living with HIV in sub-Saharan Africa
Children and adolescents living with HIV (CALHIV) in sub-Saharan Africa experience significant morbidity and alarmingly high mortality rates due to critical gaps in the HIV care cascade, including late diagnosis and initiation of treatment, as well as poor retention in care and adherence to treatmen...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-11-01
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| Series: | Journal of Virus Eradication |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2055664020303447 |
| _version_ | 1830176821967060992 |
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| author | Leslie A. Enane Mary-Ann Davies Valériane Leroy Andrew Edmonds Edith Apondi Adebola Adedimeji Rachel C. Vreeman |
| author_facet | Leslie A. Enane Mary-Ann Davies Valériane Leroy Andrew Edmonds Edith Apondi Adebola Adedimeji Rachel C. Vreeman |
| author_sort | Leslie A. Enane |
| collection | DOAJ |
| description | Children and adolescents living with HIV (CALHIV) in sub-Saharan Africa experience significant morbidity and alarmingly high mortality rates due to critical gaps in the HIV care cascade, including late diagnosis and initiation of treatment, as well as poor retention in care and adherence to treatment. Interventions to strengthen the adult HIV care cascade may not be as effective in improving the cascade for CALHIV, for whom specific strategies are needed. Particular attention needs to be paid to the contexts of sub-Saharan Africa, where more than 85% of the world's CALHIV live. Implementing the ‘treat all’ strategy in sub-Saharan Africa requires dedicated efforts to address the unique diagnosis and care needs of CALHIV, in order to improve paediatric and adolescent outcomes, prevent viral resistance and reduce the number of new HIV infections. We consider the UNAIDS 90-90-90 targets from the perspective of infants, children and adolescents, and discuss the key challenges, knowledge gaps and urgent research priorities for CALHIV in implementation of the ‘treat all’ strategy in sub-Saharan Africa. |
| first_indexed | 2024-12-17T19:13:23Z |
| format | Article |
| id | doaj.art-abb838a285544b018199c5501c96df4b |
| institution | Directory Open Access Journal |
| issn | 2055-6640 |
| language | English |
| last_indexed | 2024-12-17T19:13:23Z |
| publishDate | 2018-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Virus Eradication |
| spelling | doaj.art-abb838a285544b018199c5501c96df4b2022-12-21T21:35:49ZengElsevierJournal of Virus Eradication2055-66402018-11-0144046Traversing the cascade: urgent research priorities for implementing the ‘treat all’ strategy for children and adolescents living with HIV in sub-Saharan AfricaLeslie A. Enane0Mary-Ann Davies1Valériane Leroy2Andrew Edmonds3Edith Apondi4Adebola Adedimeji5Rachel C. Vreeman6Ryan White Center for Pediatric Infectious Disease and Global Health, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA; Corresponding author: Leslie Enane, 1044 W Walnut Street, Room 402A, Indianapolis, Indiana, 46202, USACenter for Infectious Disease Epidemiology and Research, University of Cape Town, South AfricaInserm (French Institute of Health and Medical Research), UMR 1027, Université Toulouse 3, FranceDepartment of Epidemiology, University of North Carolina at Chapel Hill, NC, USAMoi Teaching and Referral Hospital, Eldoret, KenyaDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USARyan White Center for Pediatric Infectious Disease and Global Health, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USAChildren and adolescents living with HIV (CALHIV) in sub-Saharan Africa experience significant morbidity and alarmingly high mortality rates due to critical gaps in the HIV care cascade, including late diagnosis and initiation of treatment, as well as poor retention in care and adherence to treatment. Interventions to strengthen the adult HIV care cascade may not be as effective in improving the cascade for CALHIV, for whom specific strategies are needed. Particular attention needs to be paid to the contexts of sub-Saharan Africa, where more than 85% of the world's CALHIV live. Implementing the ‘treat all’ strategy in sub-Saharan Africa requires dedicated efforts to address the unique diagnosis and care needs of CALHIV, in order to improve paediatric and adolescent outcomes, prevent viral resistance and reduce the number of new HIV infections. We consider the UNAIDS 90-90-90 targets from the perspective of infants, children and adolescents, and discuss the key challenges, knowledge gaps and urgent research priorities for CALHIV in implementation of the ‘treat all’ strategy in sub-Saharan Africa.http://www.sciencedirect.com/science/article/pii/S2055664020303447childrenadolescentsHIV/AIDSsub-Saharan AfricaHIV care cascadeHIV care continuum |
| spellingShingle | Leslie A. Enane Mary-Ann Davies Valériane Leroy Andrew Edmonds Edith Apondi Adebola Adedimeji Rachel C. Vreeman Traversing the cascade: urgent research priorities for implementing the ‘treat all’ strategy for children and adolescents living with HIV in sub-Saharan Africa Journal of Virus Eradication children adolescents HIV/AIDS sub-Saharan Africa HIV care cascade HIV care continuum |
| title | Traversing the cascade: urgent research priorities for implementing the ‘treat all’ strategy for children and adolescents living with HIV in sub-Saharan Africa |
| title_full | Traversing the cascade: urgent research priorities for implementing the ‘treat all’ strategy for children and adolescents living with HIV in sub-Saharan Africa |
| title_fullStr | Traversing the cascade: urgent research priorities for implementing the ‘treat all’ strategy for children and adolescents living with HIV in sub-Saharan Africa |
| title_full_unstemmed | Traversing the cascade: urgent research priorities for implementing the ‘treat all’ strategy for children and adolescents living with HIV in sub-Saharan Africa |
| title_short | Traversing the cascade: urgent research priorities for implementing the ‘treat all’ strategy for children and adolescents living with HIV in sub-Saharan Africa |
| title_sort | traversing the cascade urgent research priorities for implementing the treat all strategy for children and adolescents living with hiv in sub saharan africa |
| topic | children adolescents HIV/AIDS sub-Saharan Africa HIV care cascade HIV care continuum |
| url | http://www.sciencedirect.com/science/article/pii/S2055664020303447 |
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