The mutational pattern of homologous recombination (HR)-associated genes and its relevance to the immunotherapeutic response in gastric cancer

The mutational pattern of homologous recombination (HR)-associated genes and its relevance to the immunotherapeutic response in gastric cancer

Objective: Currently, there is an urgent need to identify immunotherapeutic biomarkers to increase the benefit of immune checkpoint inhibitors (ICIs) for patients with gastric cancer (GC). Homologous recombination deficiency (HRD) can modify the tumor immune microenvironment by increasing the presen...

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Bibliographic Details
Main Authors: Yue Fan, Haifeng Ying, Xueying Wu, Huan Chen, Ying Hu, Henghui Zhang, Lijia Wu, Ying Yang, Beibei Mao, Lan Zheng
Format: Article
Language:English
Published: China Anti-Cancer Association 2020-11-01
Series:Cancer Biology & Medicine
Subjects:
gastric cancer
homologous recombination deficiency
immunotherapy
biomarker
Online Access:http://www.cancerbiomed.org/index.php/cocr/article/view/1697

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