Demographics and treatment of patients with primary nephrotic syndrome in Japan using a national registry of clinical personal records
Abstract The nationwide clinical features of Japanese patients with primary nephrotic syndrome (NS), including minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), or membranous nephropathy (MN), have not yet been reported. We collected the clinical personal records of patients w...
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| Format: | Article |
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Nature Portfolio
2023-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-41909-5 |
| _version_ | 1827723254165405696 |
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| author | Naoki Nakagawa Tomonori Kimura Ryuichi Sakate Takehiko Wada Kengo Furuichi Hirokazu Okada Yoshitaka Isaka Ichiei Narita |
| author_facet | Naoki Nakagawa Tomonori Kimura Ryuichi Sakate Takehiko Wada Kengo Furuichi Hirokazu Okada Yoshitaka Isaka Ichiei Narita |
| author_sort | Naoki Nakagawa |
| collection | DOAJ |
| description | Abstract The nationwide clinical features of Japanese patients with primary nephrotic syndrome (NS), including minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), or membranous nephropathy (MN), have not yet been reported. We collected the clinical personal records of patients with primary NS between 2015 and 2018 from the national registry organized by the Japanese Ministry of Health, Labour, and Welfare. Overall, the demographics, chronic kidney disease classification based on glomerular filtration rate and albuminuria, and treatment of 6036 patients were collected: 3394 (56.2%) with MCD, 677 (11.2%) with FSGS, 1455 (24.1%) with MN, and 510 (8.5%) with others. MN patients were older than MCD and FSGS patients (67 vs. 42 and 47 years, respectively). Steroid-dependent NS or frequently relapsing NS was found in 70.2%, 40.5%, and 24.6%, whereas steroid-resistant NS was found in 6.4%, 36.0%, and 37.9% of patients in the MCD, FSGS, and MN, respectively. The present oral prednisolone use (mean dose, mg/day) was 87.2% (21.2), 80.9% (20.0), and 77.5% (18.8) of patients in the MCD, FSGS, and MN, respectively. The national registry of clinical personal records of primary NS could provide an informative insight into the characteristics, clinical features, and treatment approaches for patients with primary NS in Japan. |
| first_indexed | 2024-03-10T21:57:42Z |
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| id | doaj.art-abb8f7ba4c4b4d2fb79f74ffa14f7cb7 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T21:57:42Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-abb8f7ba4c4b4d2fb79f74ffa14f7cb72023-11-19T13:04:26ZengNature PortfolioScientific Reports2045-23222023-09-0113111010.1038/s41598-023-41909-5Demographics and treatment of patients with primary nephrotic syndrome in Japan using a national registry of clinical personal recordsNaoki Nakagawa0Tomonori Kimura1Ryuichi Sakate2Takehiko Wada3Kengo Furuichi4Hirokazu Okada5Yoshitaka Isaka6Ichiei Narita7Division of Cardiology, Nephrology, Pulmonology and Neurology, Department of Internal Medicine, Asahikawa Medical UniversityReverse Translational Research Project, Center for Rare Disease Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)Reverse Translational Research Project, Center for Rare Disease Research, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)Division of Nephrology, Endocrinology and Metabolism, Tokai University School of MedicineDepartment of Nephrology, Kanazawa Medical University School of MedicineDepartment of Nephrology, Faculty of Medicine, Saitama Medical UniversityDepartment of Nephrology, Osaka University Graduate School of MedicineDivision of Clinical Nephrology and Rheumatology, Kidney Research Center, Niigata University Graduate School of Medical and Dental SciencesAbstract The nationwide clinical features of Japanese patients with primary nephrotic syndrome (NS), including minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), or membranous nephropathy (MN), have not yet been reported. We collected the clinical personal records of patients with primary NS between 2015 and 2018 from the national registry organized by the Japanese Ministry of Health, Labour, and Welfare. Overall, the demographics, chronic kidney disease classification based on glomerular filtration rate and albuminuria, and treatment of 6036 patients were collected: 3394 (56.2%) with MCD, 677 (11.2%) with FSGS, 1455 (24.1%) with MN, and 510 (8.5%) with others. MN patients were older than MCD and FSGS patients (67 vs. 42 and 47 years, respectively). Steroid-dependent NS or frequently relapsing NS was found in 70.2%, 40.5%, and 24.6%, whereas steroid-resistant NS was found in 6.4%, 36.0%, and 37.9% of patients in the MCD, FSGS, and MN, respectively. The present oral prednisolone use (mean dose, mg/day) was 87.2% (21.2), 80.9% (20.0), and 77.5% (18.8) of patients in the MCD, FSGS, and MN, respectively. The national registry of clinical personal records of primary NS could provide an informative insight into the characteristics, clinical features, and treatment approaches for patients with primary NS in Japan.https://doi.org/10.1038/s41598-023-41909-5 |
| spellingShingle | Naoki Nakagawa Tomonori Kimura Ryuichi Sakate Takehiko Wada Kengo Furuichi Hirokazu Okada Yoshitaka Isaka Ichiei Narita Demographics and treatment of patients with primary nephrotic syndrome in Japan using a national registry of clinical personal records Scientific Reports |
| title | Demographics and treatment of patients with primary nephrotic syndrome in Japan using a national registry of clinical personal records |
| title_full | Demographics and treatment of patients with primary nephrotic syndrome in Japan using a national registry of clinical personal records |
| title_fullStr | Demographics and treatment of patients with primary nephrotic syndrome in Japan using a national registry of clinical personal records |
| title_full_unstemmed | Demographics and treatment of patients with primary nephrotic syndrome in Japan using a national registry of clinical personal records |
| title_short | Demographics and treatment of patients with primary nephrotic syndrome in Japan using a national registry of clinical personal records |
| title_sort | demographics and treatment of patients with primary nephrotic syndrome in japan using a national registry of clinical personal records |
| url | https://doi.org/10.1038/s41598-023-41909-5 |
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