The minipig intraoral dental implant model: A systematic review and meta-analysis
<h4>Objectives</h4> The objective of this report was to provide a review of the minipig intraoral dental implant model including a meta-analysis to estimate osseointegration and crestal bone remodeling. <h4>Methods</h4> A systematic review including PubMed and EMBASE database...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884544/?tool=EBI |
| _version_ | 1811219853939310592 |
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| author | Marta Liliana Musskopf Amanda Finger Stadler Ulf ME Wikesjö Cristiano Susin |
| author_facet | Marta Liliana Musskopf Amanda Finger Stadler Ulf ME Wikesjö Cristiano Susin |
| author_sort | Marta Liliana Musskopf |
| collection | DOAJ |
| description | <h4>Objectives</h4> The objective of this report was to provide a review of the minipig intraoral dental implant model including a meta-analysis to estimate osseointegration and crestal bone remodeling. <h4>Methods</h4> A systematic review including PubMed and EMBASE databases through June 2021 was conducted. Two independent examiners screened titles/abstracts and selected full-text articles. Studies evaluating titanium dental implant osseointegration in native alveolar bone were included. A quality assessment of reporting was performed. Random-effects meta-analyses and meta-regressions were produced for bone-implant contact (BIC), first BIC, and crestal bone level. <h4>Results</h4> 125 out of 249 full-text articles were reviewed, 55 original studies were included. Quality of reporting was generally low, omissions included animal characteristics, examiner masking/calibration, and sample size calculation. The typical minipig model protocol included surgical extraction of the mandibular premolars and first molar, 12±4 wks post-extraction healing, placement of three narrow regular length dental implants per jaw quadrant, submerged implant healing and 8 wks of osseointegration. Approximately 90% of studies reported undecalcified incandescent light microscopy histometrics. Overall, mean BIC was 59.88% (95%CI: 57.43–62.33). BIC increased significantly over time (p<0.001): 40.93 (95%CI: 34.95–46.90) at 2 wks, 58.37% (95%CI: 54.38–62.36) at 4 wks, and 66.33% (95%CI: 63.45–69.21) beyond 4 wks. Variability among studies was mainly explained by differences in observation interval post-extraction and post-implant placement, and implant surface. Heterogeneity was high for all studies (I2 > 90%, p<0.001). <h4>Conclusions</h4> The minipig intraoral dental implant model appears to effectively demonstrate osseointegration and alveolar bone remodeling similar to that observed in humans and canine models. |
| first_indexed | 2024-04-12T07:32:52Z |
| format | Article |
| id | doaj.art-abb945da04c0423ca8bb0e7619fafc5b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T07:32:52Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-abb945da04c0423ca8bb0e7619fafc5b2022-12-22T03:42:01ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01172The minipig intraoral dental implant model: A systematic review and meta-analysisMarta Liliana MusskopfAmanda Finger StadlerUlf ME WikesjöCristiano Susin<h4>Objectives</h4> The objective of this report was to provide a review of the minipig intraoral dental implant model including a meta-analysis to estimate osseointegration and crestal bone remodeling. <h4>Methods</h4> A systematic review including PubMed and EMBASE databases through June 2021 was conducted. Two independent examiners screened titles/abstracts and selected full-text articles. Studies evaluating titanium dental implant osseointegration in native alveolar bone were included. A quality assessment of reporting was performed. Random-effects meta-analyses and meta-regressions were produced for bone-implant contact (BIC), first BIC, and crestal bone level. <h4>Results</h4> 125 out of 249 full-text articles were reviewed, 55 original studies were included. Quality of reporting was generally low, omissions included animal characteristics, examiner masking/calibration, and sample size calculation. The typical minipig model protocol included surgical extraction of the mandibular premolars and first molar, 12±4 wks post-extraction healing, placement of three narrow regular length dental implants per jaw quadrant, submerged implant healing and 8 wks of osseointegration. Approximately 90% of studies reported undecalcified incandescent light microscopy histometrics. Overall, mean BIC was 59.88% (95%CI: 57.43–62.33). BIC increased significantly over time (p<0.001): 40.93 (95%CI: 34.95–46.90) at 2 wks, 58.37% (95%CI: 54.38–62.36) at 4 wks, and 66.33% (95%CI: 63.45–69.21) beyond 4 wks. Variability among studies was mainly explained by differences in observation interval post-extraction and post-implant placement, and implant surface. Heterogeneity was high for all studies (I2 > 90%, p<0.001). <h4>Conclusions</h4> The minipig intraoral dental implant model appears to effectively demonstrate osseointegration and alveolar bone remodeling similar to that observed in humans and canine models.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884544/?tool=EBI |
| spellingShingle | Marta Liliana Musskopf Amanda Finger Stadler Ulf ME Wikesjö Cristiano Susin The minipig intraoral dental implant model: A systematic review and meta-analysis PLoS ONE |
| title | The minipig intraoral dental implant model: A systematic review and meta-analysis |
| title_full | The minipig intraoral dental implant model: A systematic review and meta-analysis |
| title_fullStr | The minipig intraoral dental implant model: A systematic review and meta-analysis |
| title_full_unstemmed | The minipig intraoral dental implant model: A systematic review and meta-analysis |
| title_short | The minipig intraoral dental implant model: A systematic review and meta-analysis |
| title_sort | minipig intraoral dental implant model a systematic review and meta analysis |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8884544/?tool=EBI |
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