Association of angiotensin receptor 2 gene polymorphisms with pregnancy induced hypertension risk
Objectives: To investigate the association of polymorphisms and haplotypes of angiotensin receptor 2 (AT2R) gene with pregnancy induced hypertension (PIH) in Chinese Han women. Methods: A case-control study was designed with 446 cases (gestational hypertension, GH: 124; pre-eclampsia, PE + eclampsia...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-04-01
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| Series: | Hypertension in Pregnancy |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641955.2018.1460666 |
| _version_ | 1797681599887704064 |
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| author | Chenyang Li Weijun Peng Heng Zhang Weirong Yan |
| author_facet | Chenyang Li Weijun Peng Heng Zhang Weirong Yan |
| author_sort | Chenyang Li |
| collection | DOAJ |
| description | Objectives: To investigate the association of polymorphisms and haplotypes of angiotensin receptor 2 (AT2R) gene with pregnancy induced hypertension (PIH) in Chinese Han women. Methods: A case-control study was designed with 446 cases (gestational hypertension, GH: 124; pre-eclampsia, PE + eclampsia, E: 322) and 650 controls. rs5193, rs1403543 and rs12710567 of AT2R gene were genotyped. A logistic regression approach was applied to estimate the relationship between the polymorphisms and haplotypes of AT2Rgene with PIH risk. Results: No relationship between AT2R gene polymorphisms and PIH was detected. The haplotype analysis also showed a negative result. Conclusions: rs5193, rs1403543 and rs12710567 of AT2R gene might have no effect on PIH risk among Chinese Han women. |
| first_indexed | 2024-03-11T23:47:17Z |
| format | Article |
| id | doaj.art-abb9bb5f3ab24d6184309f920ab16d47 |
| institution | Directory Open Access Journal |
| issn | 1064-1955 1525-6065 |
| language | English |
| last_indexed | 2024-03-11T23:47:17Z |
| publishDate | 2018-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hypertension in Pregnancy |
| spelling | doaj.art-abb9bb5f3ab24d6184309f920ab16d472023-09-19T09:24:42ZengTaylor & Francis GroupHypertension in Pregnancy1064-19551525-60652018-04-01372879210.1080/10641955.2018.14606661460666Association of angiotensin receptor 2 gene polymorphisms with pregnancy induced hypertension riskChenyang Li0Weijun Peng1Heng Zhang2Weirong Yan3Tongji Medical College of Huazhong University of Science & TechnologyTongji Medical College of Huazhong University of Science & TechnologyTongji Medical College of Huazhong University of Science & TechnologyTongji Medical College of Huazhong University of Science & TechnologyObjectives: To investigate the association of polymorphisms and haplotypes of angiotensin receptor 2 (AT2R) gene with pregnancy induced hypertension (PIH) in Chinese Han women. Methods: A case-control study was designed with 446 cases (gestational hypertension, GH: 124; pre-eclampsia, PE + eclampsia, E: 322) and 650 controls. rs5193, rs1403543 and rs12710567 of AT2R gene were genotyped. A logistic regression approach was applied to estimate the relationship between the polymorphisms and haplotypes of AT2Rgene with PIH risk. Results: No relationship between AT2R gene polymorphisms and PIH was detected. The haplotype analysis also showed a negative result. Conclusions: rs5193, rs1403543 and rs12710567 of AT2R gene might have no effect on PIH risk among Chinese Han women.http://dx.doi.org/10.1080/10641955.2018.1460666angiotensin receptor 2pregnancy induced hypertensionsingle nucleotide polymorphismshaplotype analysis |
| spellingShingle | Chenyang Li Weijun Peng Heng Zhang Weirong Yan Association of angiotensin receptor 2 gene polymorphisms with pregnancy induced hypertension risk Hypertension in Pregnancy angiotensin receptor 2 pregnancy induced hypertension single nucleotide polymorphisms haplotype analysis |
| title | Association of angiotensin receptor 2 gene polymorphisms with pregnancy induced hypertension risk |
| title_full | Association of angiotensin receptor 2 gene polymorphisms with pregnancy induced hypertension risk |
| title_fullStr | Association of angiotensin receptor 2 gene polymorphisms with pregnancy induced hypertension risk |
| title_full_unstemmed | Association of angiotensin receptor 2 gene polymorphisms with pregnancy induced hypertension risk |
| title_short | Association of angiotensin receptor 2 gene polymorphisms with pregnancy induced hypertension risk |
| title_sort | association of angiotensin receptor 2 gene polymorphisms with pregnancy induced hypertension risk |
| topic | angiotensin receptor 2 pregnancy induced hypertension single nucleotide polymorphisms haplotype analysis |
| url | http://dx.doi.org/10.1080/10641955.2018.1460666 |
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