Neuroprotective and MAOB inhibitory effects of a series of caffeine-8-thioglycolic acid amides

Neuroprotective and MAOB inhibitory effects of a series of caffeine-8-thioglycolic acid amides

The effects of new derivatives of caffeine-8-thioglycolic acid (100 µM) on isolated rat brain synaptosomes, human neuroblastoma cell line SH-SY5Y and human recombinant MAOB enzyme (hMAOB) (1 µM) were evaluated. Most of the compounds, administered alone, didn’t show statistically significant neurotox...

Full description

Bibliographic Details
Main Authors:	Alexandra Kasabova-Angelova, Magdalena Kondeva-Burdina, Javor Mitkov, Maya Georgieva, Virginia Tzankova, Alexander Zlatkov
Format:	Article
Language:	English
Published:	Universidade de São Paulo 2020-03-01
Series:	Brazilian Journal of Pharmaceutical Sciences
Subjects:	Neuroprotection Caffeine Synaptosomes SH-SY5Y hMAOB
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100529&tlng=en

Similar Items

The Association between a MAOB Variable Number Tandem Repeat Polymorphism and Cocaine and Opiate Addictions in Polyconsumers
by: César Mateu, et al.
Published: (2021-09-01)

Synthesis, DFT Study, and In Vitro Evaluation of Antioxidant Properties and Cytotoxic and Cytoprotective Effects of New Hydrazones on SH-SY5Y Neuroblastoma Cell Lines
by: Diana Tzankova, et al.
Published: (2023-08-01)

Revisiting the Role of Astrocytic MAOB in Parkinson’s Disease
by: Min-Ho Nam, et al.
Published: (2022-04-01)

Study on the Neuroprotective, Radical-Scavenging and MAO-B Inhibiting Properties of New Benzimidazole Arylhydrazones as Potential Multi-Target Drugs for the Treatment of Parkinson’s Disease
by: Neda Anastassova, et al.
Published: (2022-04-01)

Newly Synthesized Creatine Derivatives as Potential Neuroprotective and Antioxidant Agents on In Vitro Models of Parkinson’s Disease
by: Ivanka Kostadinova, et al.
Published: (2023-01-01)

Design, synthesis and evaluation of semi- and thiosemicarbazides containing a methylxanthine moiety with in vitro neuroprotective and MAO-B inhibitory activities
by: Javor Mitkov, et al.
Published: (2022-12-01)

Integrated structure model-based virtual screening approaches identified anti-cancer agents against prostate cancer by targeting MAOB protein
by: Mohammad Habibur Rahman Molla, et al.
Published: (2023-08-01)

Monoamino oxidase alleles correlate with the presence of essential hypertension among hypogonadic patients
by: José Luis Royo, et al.
Published: (2020-01-01)

Quantitative Structure–Neurotoxicity Assessment and In Vitro Evaluation of Neuroprotective and MAO-B Inhibitory Activities of Series <i>N</i>′-substituted 3-(1,3,7-trimethyl-xanthin-8-ylthio)propanehydrazides
by: Magdalena Kondeva-Burdina, et al.
Published: (2022-08-01)

Neuroprotective Effect of Caffeine in Alzheimer’s Disease
by: Y Mukish M Yelanchezian, et al.
Published: (2022-06-01)

Neuroprotective effect of nicorandil in 6-OHDA induced in vitro model of parkinson's disease
by: Ufuk Okkay, et al.
Published: (2022-03-01)

Caffeine and caffeine hydrate (first revision)
by: 982 SIRIM

Caffeine, coffee, and health /
by: Garattini, Silvio
Published: (1993)

Monoamine Oxidase B Expression Correlates with a Poor Prognosis in Colorectal Cancer Patients and Is Significantly Associated with Epithelial-to-Mesenchymal Transition-Related Gene Signatures
by: Yi-Chieh Yang, et al.
Published: (2020-04-01)

The neuroprotective effects of the combined extract of mulberry fruit and mulberry leaf against hydrogen peroxide-induced cytotoxicity in SH-SY5Y Cells
by: Nootchanat Mairuae, et al.
Published: (2023-04-01)

Cytokinin Plant Hormones Have Neuroprotective Activity in In Vitro Models of Parkinson’s Disease
by: Gabriel Gonzalez, et al.
Published: (2021-01-01)

Neuroprotective effects of dendrobium endophytes metabolites in SH-SY5Y cells via the Nrf2/Keap1 pathway
by: Yan tian Liang, et al.
Published: (2024-03-01)

Caffeine and health /
by: 214492 James, Jack E
Published: (1991)

Human coculture model of astrocytes and SH-SY5Y cells to test the neurotoxicity of chemicals
by: Seungmin Park, et al.
Published: (2024-01-01)

Estimate the prevalence of daily caffeine consumption, caffeine use disorder, caffeine withdrawal and perceived harm in Iran: a cross-sectional study
by: Fatemeh Abdoli, et al.
Published: (2024-04-01)

Caffeine : chemistry, analysis, function and effects /
by: Preedy, Victor R., et al.
Published: (2012)

Hesperidin Plays Neuroprotective Effects Against Quinolinic Acid in Human SH-SY5Y Cells: Focusing on ROS Levels and Cell Cycle Arrest
by: Farzaneh Abbasinezhad-Moud, et al.
Published: (2024-01-01)

Irreversible methadone-induced GSTP1 downregulation in SH-SY5Y cells
by: Khyber Saify, et al.
Published: (2024-03-01)

Neuroprotective Effects of a Novel Tetrapeptide SGGY from Walnut against H<sub>2</sub>O<sub>2</sub>-Stimulated Oxidative Stress in SH-SY5Y Cells: Possible Involved JNK, p38 and Nrf2 Signaling Pathways
by: Li Feng, et al.
Published: (2023-04-01)

p-Hydroxybenzyl Alcohol Antagonized the ROS-Dependent JNK/Jun/Caspase-3 Pathway to Produce Neuroprotection in a Cellular Model of Parkinson’s Disease
by: Mei-Chou Lai, et al.
Published: (2022-11-01)

Identification of the Candidate mGlu2 Allosteric Modulator THRX-195518 through In Silico Method and Evaluation of Its Neuroprotective Potential against Glutamate-Induced Neurotoxicity in SH-SY5Y Cell Line
by: Fadime Canbolat, et al.
Published: (2024-01-01)

Natural Approaches for Neurological Disorders—The Neuroprotective Potential of <i>Codium tomentosum</i>
by: Joana Silva, et al.
Published: (2020-11-01)

Motivations for Caffeine Consumption in New Zealand Tertiary Students
by: Saskia Stachyshyn, et al.
Published: (2021-11-01)

Caffeine – An Enigma
by: Hetal Rathod
Published: (2023-06-01)

Caffeine Consumption & Perception of Its Effects Amongst University Students
by: Roop Zahra, et al.
Published: (2021-01-01)

Motives for Caffeine Consumption Questionnaire (MCCQ): validity and reliability of Turkish version
by: Tuğba Küçükkasap, et al.
Published: (2024-01-01)

Characterization and Identification of Caffeine-Degrading Bacteria KAJ 36
by: Sattya Arimurti, et al.
Published: (2020-08-01)

Combined Treatment with Three Natural Antioxidants Enhances Neuroprotection in a SH-SY5Y 3D Culture Model
by: Pasquale Marrazzo, et al.
Published: (2019-09-01)

Caffeine Consumption in a Group of Adolescents from South East Poland—A Cross Sectional Study
by: Ewa Błaszczyk-Bębenek, et al.
Published: (2021-06-01)

An Exploratory Study about the Characterization of Caffeine Consumption in a Portuguese Sample
by: Patrícia Batista, et al.
Published: (2022-10-01)

Metabolomics comparison of metabolites and functional pathways in the SH-SY5Y cell model of Parkinson's disease under PEMF exposure
by: Li-na Zhu, et al.
Published: (2024-02-01)

Evaluation of the Potential Protective Effect of Ellagic Acid against Heavy Metal (Cadmium, Mercury, and Lead) Toxicity in SH-SY5Y Neuroblastoma Cells
by: Rosanna Mallamaci, et al.
Published: (2024-01-01)

Design, Preparation, and Evaluation of Osthol Poly-Butyl-Cyanoacrylate Nanoparticles with Improved In Vitro Anticancer Activity in Neuroblastoma Treatment
by: Liqing Zheng, et al.
Published: (2022-10-01)

Investigating SH-SY5Y Neuroblastoma Cell Surfaceome as a Model for Neuronal-Targeted Novel Therapeutic Modalities
by: Pooja Gangras, et al.
Published: (2022-12-01)

Function of Host Protein Staufen1 in Rabies Virus Replication
by: Gaowen Liu, et al.
Published: (2021-07-01)