Control of STING Agonistic/Antagonistic Activity Using Amine-Skeleton-Based c-di-GMP Analogues

Control of STING Agonistic/Antagonistic Activity Using Amine-Skeleton-Based c-di-GMP Analogues

Stimulator of Interferon Genes (STING) is a type of endoplasmic reticulum (ER)-membrane receptor. STING is activated by a ligand binding, which leads to an enhancement of the immune-system response. Therefore, a STING ligand can be used to regulate the immune system in therapeutic strategies. Howeve...

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Bibliographic Details
Main Authors: Yuta Yanase, Genichiro Tsuji, Miki Nakamura, Norihito Shibata, Yosuke Demizu
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
STING
cyclic dinucleotide
amines
drug design
agonist
antagonist
Online Access:https://www.mdpi.com/1422-0067/23/12/6847

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