Influence of alcohol consumption on the levels of surfactant proteins SP-A and SP-D in blood in men and women in Novosibirsk
The purpose of the study is to associate alcohol consumption with the level of surfactant proteins SP-A and SP-D in Novosibirsk population. Material and methods. 174 people (87 men and 87 women) aged from 45 to 69 were examined. The study participants were randomly selected. Alcohol consumption was...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Siberian Branch Publishing House
2023-10-01
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| Series: | Сибирский научный медицинский журнал |
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| Online Access: | https://sibmed.elpub.ru/jour/article/view/1251 |
| _version_ | 1826575713744977920 |
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| author | K. Yu. Nikolaev I. A. Kosarev N. F. Dadashova Ya. K. Lapitskaya |
| author_facet | K. Yu. Nikolaev I. A. Kosarev N. F. Dadashova Ya. K. Lapitskaya |
| author_sort | K. Yu. Nikolaev |
| collection | DOAJ |
| description | The purpose of the study is to associate alcohol consumption with the level of surfactant proteins SP-A and SP-D in Novosibirsk population. Material and methods. 174 people (87 men and 87 women) aged from 45 to 69 were examined. The study participants were randomly selected. Alcohol consumption was assessed using the AUDIT test. The content of surfactant proteins SP-A and SP-D in blood serum was determined by enzyme immunoassay using standard ELISA test sets. Statistical analysis was performed using parametric and nonparametric methods of descriptive statistics, correlation analysis was performed using Spearman criterion, and multivariate analysis was performed using binary logistic regression. ROC analysis was used to evaluate the diagnostic significance of the variables and to determine sensitivity and specificity. The critical level of significance for the null hypothesis (p) was accepted to be 0.05 in all statistical analysis procedures. Results. A typical single dose of alcohol consumed of 7–9 alcohol units (TSDAC) was inversely associated with SP-A content (r = –0.154, p = 0.043) in a general sample of men and women aged 45–59 years in Novosibirsk. By means of ROC analysis, SP-A was found to be a marker (area under the ROC curve equals 71.2 %) of alcohol intake in TSDAC. With a SP-A level not more than 921 pg/ml, its sensitivity to the determination of alcohol consumption in TSDAC is 68.7 %, the specificity is 87.5 %. Regression analysis showed that the variable “TSDAC” directly affects the presence of SP-A in a concentration not preceding 921 pg/ml (Exp (B) = 13.0; 95 % CI = 1.5; 111.0, p = 0.019) regardless of age and sex. In the general sample of men and women in Novosibirsk aged 45–69 years, as well as in men, inverse associations of Sp-D content with the presence of >0 points were found in the answer to the AUDIT test question “How often during the last year have you not done something that was expected of you?”. It was determined that women had a higher level of SP-A in the blood than men. Perhaps this is due to the fact that women smoked less often than men (10.3 and 23.0 %, respectively, p = 0.020). So, it was established that a high TSDAC is an independent factor directly influencing the presence of SP-A level in the blood not exceeding 921 pg/ml for men and women aged 45–69 years in Novosibirsk. |
| first_indexed | 2024-03-08T14:33:14Z |
| format | Article |
| id | doaj.art-abbb543c4a644b1b886e5bf31b40389b |
| institution | Directory Open Access Journal |
| issn | 2410-2512 2410-2520 |
| language | Russian |
| last_indexed | 2025-03-14T13:19:05Z |
| publishDate | 2023-10-01 |
| publisher | Russian Academy of Sciences, Siberian Branch Publishing House |
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| series | Сибирский научный медицинский журнал |
| spelling | doaj.art-abbb543c4a644b1b886e5bf31b40389b2025-02-28T13:43:59ZrusRussian Academy of Sciences, Siberian Branch Publishing HouseСибирский научный медицинский журнал2410-25122410-25202023-10-0143513514210.18699/SSMJ20230514547Influence of alcohol consumption on the levels of surfactant proteins SP-A and SP-D in blood in men and women in NovosibirskK. Yu. Nikolaev0I. A. Kosarev1N. F. Dadashova2Ya. K. Lapitskaya3Research Institute of Internal and Preventive Medicine – Branch of the Federal Research Center Institute of Cytology and Genetics SB RAS; Surgut State University; Novosibirsk State UniversityResearch Institute of Internal and Preventive Medicine – Branch of the Federal Research Center Institute of Cytology and Genetics SB RASSurgut State UniversityNovosibirsk State UniversityThe purpose of the study is to associate alcohol consumption with the level of surfactant proteins SP-A and SP-D in Novosibirsk population. Material and methods. 174 people (87 men and 87 women) aged from 45 to 69 were examined. The study participants were randomly selected. Alcohol consumption was assessed using the AUDIT test. The content of surfactant proteins SP-A and SP-D in blood serum was determined by enzyme immunoassay using standard ELISA test sets. Statistical analysis was performed using parametric and nonparametric methods of descriptive statistics, correlation analysis was performed using Spearman criterion, and multivariate analysis was performed using binary logistic regression. ROC analysis was used to evaluate the diagnostic significance of the variables and to determine sensitivity and specificity. The critical level of significance for the null hypothesis (p) was accepted to be 0.05 in all statistical analysis procedures. Results. A typical single dose of alcohol consumed of 7–9 alcohol units (TSDAC) was inversely associated with SP-A content (r = –0.154, p = 0.043) in a general sample of men and women aged 45–59 years in Novosibirsk. By means of ROC analysis, SP-A was found to be a marker (area under the ROC curve equals 71.2 %) of alcohol intake in TSDAC. With a SP-A level not more than 921 pg/ml, its sensitivity to the determination of alcohol consumption in TSDAC is 68.7 %, the specificity is 87.5 %. Regression analysis showed that the variable “TSDAC” directly affects the presence of SP-A in a concentration not preceding 921 pg/ml (Exp (B) = 13.0; 95 % CI = 1.5; 111.0, p = 0.019) regardless of age and sex. In the general sample of men and women in Novosibirsk aged 45–69 years, as well as in men, inverse associations of Sp-D content with the presence of >0 points were found in the answer to the AUDIT test question “How often during the last year have you not done something that was expected of you?”. It was determined that women had a higher level of SP-A in the blood than men. Perhaps this is due to the fact that women smoked less often than men (10.3 and 23.0 %, respectively, p = 0.020). So, it was established that a high TSDAC is an independent factor directly influencing the presence of SP-A level in the blood not exceeding 921 pg/ml for men and women aged 45–69 years in Novosibirsk.https://sibmed.elpub.ru/jour/article/view/1251alcohol consumptionaudit testbehavioral performancesurfactant proteins sp-a and sp-dsmoking |
| spellingShingle | K. Yu. Nikolaev I. A. Kosarev N. F. Dadashova Ya. K. Lapitskaya Influence of alcohol consumption on the levels of surfactant proteins SP-A and SP-D in blood in men and women in Novosibirsk Сибирский научный медицинский журнал alcohol consumption audit test behavioral performance surfactant proteins sp-a and sp-d smoking |
| title | Influence of alcohol consumption on the levels of surfactant proteins SP-A and SP-D in blood in men and women in Novosibirsk |
| title_full | Influence of alcohol consumption on the levels of surfactant proteins SP-A and SP-D in blood in men and women in Novosibirsk |
| title_fullStr | Influence of alcohol consumption on the levels of surfactant proteins SP-A and SP-D in blood in men and women in Novosibirsk |
| title_full_unstemmed | Influence of alcohol consumption on the levels of surfactant proteins SP-A and SP-D in blood in men and women in Novosibirsk |
| title_short | Influence of alcohol consumption on the levels of surfactant proteins SP-A and SP-D in blood in men and women in Novosibirsk |
| title_sort | influence of alcohol consumption on the levels of surfactant proteins sp a and sp d in blood in men and women in novosibirsk |
| topic | alcohol consumption audit test behavioral performance surfactant proteins sp-a and sp-d smoking |
| url | https://sibmed.elpub.ru/jour/article/view/1251 |
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