Ketamine infiltration improves analgesia after thyroid surgery [version 2; peer review: 1 approved, 2 approved with reservations]
Background: Postoperative pain increases the risk of postoperative complications and may predispose patients to chronic post-surgical pain. This study aims to evaluate the impact of ketamine wound infiltration versus placebo at the end of thyroid surgery on postoperative pain and analgesic requireme...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2023-08-01
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| Online Access: | https://f1000research.com/articles/12-206/v2 |
| _version_ | 1797335397548687360 |
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| author | Maroua Bouhali Khadija Ben Ayed Imen Zouche Mariam Ben Ayed Ilhem Charfeddine Mohamed Amine Chaabouni Moncef Sellami Salma Ktata Boutheina Hammami |
| author_facet | Maroua Bouhali Khadija Ben Ayed Imen Zouche Mariam Ben Ayed Ilhem Charfeddine Mohamed Amine Chaabouni Moncef Sellami Salma Ktata Boutheina Hammami |
| author_sort | Maroua Bouhali |
| collection | DOAJ |
| description | Background: Postoperative pain increases the risk of postoperative complications and may predispose patients to chronic post-surgical pain. This study aims to evaluate the impact of ketamine wound infiltration versus placebo at the end of thyroid surgery on postoperative pain and analgesic requirements. Methods: In this randomized controlled trial, we prospectively studied patients who underwent thyroid surgery. Patients were randomized into two groups: group S, where local infiltration was performed using 10 ml of a physiological saline solution; and group K, where 10 ml of a solution containing 2 mg/kg ketamine was infiltrated. Standardized thyroidectomies were performed in the 2 groups. Pain perception was measured using a visual analog scale (VAS) every 10 minutes in the post-anesthetic care unit (PACU) for 2 hours and thereafter every 6 hours during the first 24 hours. The opioid requirement in the PACU was evaluated. A comparison between the 2 groups was carried out. Results: Postoperatively, the mean VAS was higher in group S compared to group K during all PACU stay periods and the first 24 hours. Pain scores during swallowing were significantly lower for group K in the PACU at 0, 10, and 20 minutes. The mean morphine consumption in the PACU was 0.71 mg and 0 mg respectively in group S and group K (p=0.03). The incidence of nausea and vomiting was similar in both groups. Conclusions: Ketamine wound infiltration is an efficient modality to reduce postoperative opioid consumption compared to a placebo after thyroid surgery. |
| first_indexed | 2024-03-08T08:36:36Z |
| format | Article |
| id | doaj.art-abbd917006b84f1eb5dce3bd29276218 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-03-08T08:36:36Z |
| publishDate | 2023-08-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-abbd917006b84f1eb5dce3bd292762182024-02-02T01:00:05ZengF1000 Research LtdF1000Research2046-14022023-08-0112154754Ketamine infiltration improves analgesia after thyroid surgery [version 2; peer review: 1 approved, 2 approved with reservations]Maroua Bouhali0Khadija Ben Ayed1Imen Zouche2https://orcid.org/0000-0003-1638-8065Mariam Ben Ayed3https://orcid.org/0000-0001-9296-762XIlhem Charfeddine4Mohamed Amine Chaabouni5https://orcid.org/0000-0003-0880-1032Moncef Sellami6https://orcid.org/0000-0003-2409-3996Salma Ktata7Boutheina Hammami8Faculty of Medicine of Sfax, Sfax, TunisiaFaculty of Medicine of Sfax, Sfax, TunisiaFaculty of Medicine of Sfax, Sfax, TunisiaFaculty of Medicine of Sfax, Sfax, TunisiaFaculty of Medicine of Sfax, Sfax, TunisiaFaculty of Medicine of Sfax, Sfax, TunisiaFaculty of Medicine of Sfax, Sfax, TunisiaFaculty of Medicine of Sfax, Sfax, TunisiaFaculty of Medicine of Sfax, Sfax, TunisiaBackground: Postoperative pain increases the risk of postoperative complications and may predispose patients to chronic post-surgical pain. This study aims to evaluate the impact of ketamine wound infiltration versus placebo at the end of thyroid surgery on postoperative pain and analgesic requirements. Methods: In this randomized controlled trial, we prospectively studied patients who underwent thyroid surgery. Patients were randomized into two groups: group S, where local infiltration was performed using 10 ml of a physiological saline solution; and group K, where 10 ml of a solution containing 2 mg/kg ketamine was infiltrated. Standardized thyroidectomies were performed in the 2 groups. Pain perception was measured using a visual analog scale (VAS) every 10 minutes in the post-anesthetic care unit (PACU) for 2 hours and thereafter every 6 hours during the first 24 hours. The opioid requirement in the PACU was evaluated. A comparison between the 2 groups was carried out. Results: Postoperatively, the mean VAS was higher in group S compared to group K during all PACU stay periods and the first 24 hours. Pain scores during swallowing were significantly lower for group K in the PACU at 0, 10, and 20 minutes. The mean morphine consumption in the PACU was 0.71 mg and 0 mg respectively in group S and group K (p=0.03). The incidence of nausea and vomiting was similar in both groups. Conclusions: Ketamine wound infiltration is an efficient modality to reduce postoperative opioid consumption compared to a placebo after thyroid surgery.https://f1000research.com/articles/12-206/v2Ketamine thyroid surgery wound infiltration analgesiaeng |
| spellingShingle | Maroua Bouhali Khadija Ben Ayed Imen Zouche Mariam Ben Ayed Ilhem Charfeddine Mohamed Amine Chaabouni Moncef Sellami Salma Ktata Boutheina Hammami Ketamine infiltration improves analgesia after thyroid surgery [version 2; peer review: 1 approved, 2 approved with reservations] F1000Research Ketamine thyroid surgery wound infiltration analgesia eng |
| title | Ketamine infiltration improves analgesia after thyroid surgery [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_full | Ketamine infiltration improves analgesia after thyroid surgery [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_fullStr | Ketamine infiltration improves analgesia after thyroid surgery [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_full_unstemmed | Ketamine infiltration improves analgesia after thyroid surgery [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_short | Ketamine infiltration improves analgesia after thyroid surgery [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_sort | ketamine infiltration improves analgesia after thyroid surgery version 2 peer review 1 approved 2 approved with reservations |
| topic | Ketamine thyroid surgery wound infiltration analgesia eng |
| url | https://f1000research.com/articles/12-206/v2 |
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