Role of <i>Lactobacillus reuteri</i> <i>DSM 17938</i> on Crying Time Reduction in Infantile Colic and Its Impact on Maternal Depression: A Real-Life Clinic-Based Study
Background: Infantile colic is characterized by prolonged periods of inconsolable, incessant crying and persistent fussing in an otherwise healthy infant. It is a self-limiting condition, but causes significant stress to mothers. AIM: To observe the role of <i>Lactobacillus reuteri</i>&l...
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| Format: | Article |
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MDPI AG
2022-01-01
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| Series: | Clinics and Practice |
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| Online Access: | https://www.mdpi.com/2039-7283/12/1/5 |
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| author | Arun Wadhwa Dhanasekhar Kesavelu Kishore Kumar Pallab Chatterjee Pramod Jog Sarath Gopalan Rudra Paul Krishna Chaitanya Veligandla Suyog Mehta Amey Mane Sucheta Pandit Rahul Rathod Sushma Jayan Monjori Mitra |
| author_facet | Arun Wadhwa Dhanasekhar Kesavelu Kishore Kumar Pallab Chatterjee Pramod Jog Sarath Gopalan Rudra Paul Krishna Chaitanya Veligandla Suyog Mehta Amey Mane Sucheta Pandit Rahul Rathod Sushma Jayan Monjori Mitra |
| author_sort | Arun Wadhwa |
| collection | DOAJ |
| description | Background: Infantile colic is characterized by prolonged periods of inconsolable, incessant crying and persistent fussing in an otherwise healthy infant. It is a self-limiting condition, but causes significant stress to mothers. AIM: To observe the role of <i>Lactobacillus reuteri</i><i>DSM 17938</i> in reducing crying time in colicky infants in routine clinical practice. Methods: This was a prospective observational multicentric clinic-based study. Each practitioner included approximately 30 infants < 5 months of age with infantile colic who were prescribed <i>L. reuteri</i> <i>DSM 17938</i> for a period of 21 days. There were four physical consultations and two telephonic consultations. The parents were given a daily diary to record the duration of crying and fussing episodes and a questionnaire was administered during the consultations. Results: A total of 120 infants with a mean age of 56.9 ± 34.2 days were included in this 28-day study. The mean crying time as reported by the parents in the subject diary reduced from 248.2 ± 101.2 min, 95% CI: 229.45, 266.94 at baseline to 45.6 ± 79.1 min 95% CI: 31.02, 60.31 at study end (<i>P</i> < 0.01). The clinical response (defined as reduction of 50% in crying time) was observed in 85% of subjects at study end. The fussiness and parental perception of colic recorded during the consultations were reduced by 66% and 72%, respectively, at study end. The maternal depression scores were reduced to 63% at study end. Conclusion: <i>L. reuteri DSM 17938</i> was associated with a significant reduction in crying time in colicky infants, and showed improvement in maternal depression. |
| first_indexed | 2024-03-09T22:17:30Z |
| format | Article |
| id | doaj.art-abbdfe73f84a458bacd1d538f13e3285 |
| institution | Directory Open Access Journal |
| issn | 2039-7283 |
| language | English |
| last_indexed | 2024-03-09T22:17:30Z |
| publishDate | 2022-01-01 |
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| record_format | Article |
| series | Clinics and Practice |
| spelling | doaj.art-abbdfe73f84a458bacd1d538f13e32852023-11-23T19:21:42ZengMDPI AGClinics and Practice2039-72832022-01-01121374510.3390/clinpract12010005Role of <i>Lactobacillus reuteri</i> <i>DSM 17938</i> on Crying Time Reduction in Infantile Colic and Its Impact on Maternal Depression: A Real-Life Clinic-Based StudyArun Wadhwa0Dhanasekhar Kesavelu1Kishore Kumar2Pallab Chatterjee3Pramod Jog4Sarath Gopalan5Rudra Paul6Krishna Chaitanya Veligandla7Suyog Mehta8Amey Mane9Sucheta Pandit10Rahul Rathod11Sushma Jayan12Monjori Mitra13Dr. Wadhwa’s Clinic, New Delhi 110048, IndiaSS Child Care, Chennai 600037, Tamil Nadu, IndiaCloudnine Hospital, Bangalore 560066, Karnataka, IndiaOutreach Clinic, Clinical and Experimental Pharmacology, School of Tropical Medicine, Kolkata 700073, West Bengal, IndiaMedipoint Hospital, Pune 411007, Maharastra, IndiaMadhukar Rainbow Children’s Hospital, New Delhi 110017, IndiaOutreach Clinic, Clinical and Experimental Pharmacology, School of Tropical Medicine, Kolkata 700073, West Bengal, IndiaGlobal Generics India, Dr. Reddy’s Laboratories Limited, Hyderabad 500016, Telangana, IndiaGlobal Generics India, Dr. Reddy’s Laboratories Limited, Hyderabad 500016, Telangana, IndiaGlobal Generics India, Dr. Reddy’s Laboratories Limited, Hyderabad 500016, Telangana, IndiaGlobal Generics India, Dr. Reddy’s Laboratories Limited, Hyderabad 500016, Telangana, IndiaGlobal Generics India, Dr. Reddy’s Laboratories Limited, Hyderabad 500016, Telangana, IndiaMedclin Research Pvt. Ltd., Kolkata 700107, West Bengal, IndiaInstitute of Child Health, Kolkata 700017, West Bengal, IndiaBackground: Infantile colic is characterized by prolonged periods of inconsolable, incessant crying and persistent fussing in an otherwise healthy infant. It is a self-limiting condition, but causes significant stress to mothers. AIM: To observe the role of <i>Lactobacillus reuteri</i><i>DSM 17938</i> in reducing crying time in colicky infants in routine clinical practice. Methods: This was a prospective observational multicentric clinic-based study. Each practitioner included approximately 30 infants < 5 months of age with infantile colic who were prescribed <i>L. reuteri</i> <i>DSM 17938</i> for a period of 21 days. There were four physical consultations and two telephonic consultations. The parents were given a daily diary to record the duration of crying and fussing episodes and a questionnaire was administered during the consultations. Results: A total of 120 infants with a mean age of 56.9 ± 34.2 days were included in this 28-day study. The mean crying time as reported by the parents in the subject diary reduced from 248.2 ± 101.2 min, 95% CI: 229.45, 266.94 at baseline to 45.6 ± 79.1 min 95% CI: 31.02, 60.31 at study end (<i>P</i> < 0.01). The clinical response (defined as reduction of 50% in crying time) was observed in 85% of subjects at study end. The fussiness and parental perception of colic recorded during the consultations were reduced by 66% and 72%, respectively, at study end. The maternal depression scores were reduced to 63% at study end. Conclusion: <i>L. reuteri DSM 17938</i> was associated with a significant reduction in crying time in colicky infants, and showed improvement in maternal depression.https://www.mdpi.com/2039-7283/12/1/5infantile colicexcessive cryingcrying durationmaternal depressionfussiness<i>Lactobacillus</i> <i>reuteri DSM 17938</i> |
| spellingShingle | Arun Wadhwa Dhanasekhar Kesavelu Kishore Kumar Pallab Chatterjee Pramod Jog Sarath Gopalan Rudra Paul Krishna Chaitanya Veligandla Suyog Mehta Amey Mane Sucheta Pandit Rahul Rathod Sushma Jayan Monjori Mitra Role of <i>Lactobacillus reuteri</i> <i>DSM 17938</i> on Crying Time Reduction in Infantile Colic and Its Impact on Maternal Depression: A Real-Life Clinic-Based Study Clinics and Practice infantile colic excessive crying crying duration maternal depression fussiness <i>Lactobacillus</i> <i>reuteri DSM 17938</i> |
| title | Role of <i>Lactobacillus reuteri</i> <i>DSM 17938</i> on Crying Time Reduction in Infantile Colic and Its Impact on Maternal Depression: A Real-Life Clinic-Based Study |
| title_full | Role of <i>Lactobacillus reuteri</i> <i>DSM 17938</i> on Crying Time Reduction in Infantile Colic and Its Impact on Maternal Depression: A Real-Life Clinic-Based Study |
| title_fullStr | Role of <i>Lactobacillus reuteri</i> <i>DSM 17938</i> on Crying Time Reduction in Infantile Colic and Its Impact on Maternal Depression: A Real-Life Clinic-Based Study |
| title_full_unstemmed | Role of <i>Lactobacillus reuteri</i> <i>DSM 17938</i> on Crying Time Reduction in Infantile Colic and Its Impact on Maternal Depression: A Real-Life Clinic-Based Study |
| title_short | Role of <i>Lactobacillus reuteri</i> <i>DSM 17938</i> on Crying Time Reduction in Infantile Colic and Its Impact on Maternal Depression: A Real-Life Clinic-Based Study |
| title_sort | role of i lactobacillus reuteri i i dsm 17938 i on crying time reduction in infantile colic and its impact on maternal depression a real life clinic based study |
| topic | infantile colic excessive crying crying duration maternal depression fussiness <i>Lactobacillus</i> <i>reuteri DSM 17938</i> |
| url | https://www.mdpi.com/2039-7283/12/1/5 |
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