Fungal Gut Microbiota Dysbiosis and Its Role in Colorectal, Oral, and Pancreatic Carcinogenesis
The association between bacterial as well as viral gut microbiota imbalance and carcinogenesis has been intensively analysed in many studies; nevertheless, the role of fungal gut microbiota (mycobiota) in colorectal, oral, and pancreatic cancer development is relatively new and undiscovered field du...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-05-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/5/1326 |
| _version_ | 1797567241715187712 |
|---|---|
| author | Karolina Kaźmierczak-Siedlecka Aleš Dvořák Marcin Folwarski Agnieszka Daca Katarzyna Przewłócka Wojciech Makarewicz |
| author_facet | Karolina Kaźmierczak-Siedlecka Aleš Dvořák Marcin Folwarski Agnieszka Daca Katarzyna Przewłócka Wojciech Makarewicz |
| author_sort | Karolina Kaźmierczak-Siedlecka |
| collection | DOAJ |
| description | The association between bacterial as well as viral gut microbiota imbalance and carcinogenesis has been intensively analysed in many studies; nevertheless, the role of fungal gut microbiota (mycobiota) in colorectal, oral, and pancreatic cancer development is relatively new and undiscovered field due to low abundance of intestinal fungi as well as lack of well-characterized reference genomes. Several specific fungi amounts are increased in colorectal cancer patients; moreover, it was observed that the disease stage is strongly related to the fungal microbiota profile; thus, it may be used as a potential diagnostic biomarker for adenomas. <i>Candida albicans</i>, which is the major microbe contributing to oral cancer development, may promote carcinogenesis via several mechanisms, mainly triggering inflammation. Early detection of pancreatic cancer provides the opportunity to improve survival rate, therefore, there is a need to conduct further studies regarding the role of fungal microbiota as a potential prognostic tool to diagnose this cancer at early stage. Additionally, growing attention towards the characterization of mycobiota may contribute to improve the efficiency of therapeutic methods used to alter the composition and activity of gut microbiota. The administration of <i>Saccharomyces boulardii</i> in oncology, mainly in immunocompromised and/or critically ill patients, is still controversial. |
| first_indexed | 2024-03-10T19:39:58Z |
| format | Article |
| id | doaj.art-abbf6403585d4105abb09e03e6ade6a0 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T19:39:58Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-abbf6403585d4105abb09e03e6ade6a02023-11-20T01:24:38ZengMDPI AGCancers2072-66942020-05-01125132610.3390/cancers12051326Fungal Gut Microbiota Dysbiosis and Its Role in Colorectal, Oral, and Pancreatic CarcinogenesisKarolina Kaźmierczak-Siedlecka0Aleš Dvořák1Marcin Folwarski2Agnieszka Daca3Katarzyna Przewłócka4Wojciech Makarewicz5Department of Surgical Oncology, Medical University of Gdansk, 80-214 Gdańsk, PolandInstitute of Medical Biochemistry and Laboratory Diagnostics, Faculty General Hospital and 1st Faculty of Medicine, Charles University, 12108 Prague, Czech RepublicDepartment of Clinical Nutrition and Dietetics, Medical University of Gdansk, 80-211 Gdańsk, PolandDepartment of Pathology and Experimental Rheumatology, Medical University of Gdansk, 80-211 Gdańsk, PolandDepartment of Bioenergetics and Physiology of Exercise, Medical University of Gdansk, 80-210 Gdańsk, PolandDepartment of Surgical Oncology, Medical University of Gdansk, 80-214 Gdańsk, PolandThe association between bacterial as well as viral gut microbiota imbalance and carcinogenesis has been intensively analysed in many studies; nevertheless, the role of fungal gut microbiota (mycobiota) in colorectal, oral, and pancreatic cancer development is relatively new and undiscovered field due to low abundance of intestinal fungi as well as lack of well-characterized reference genomes. Several specific fungi amounts are increased in colorectal cancer patients; moreover, it was observed that the disease stage is strongly related to the fungal microbiota profile; thus, it may be used as a potential diagnostic biomarker for adenomas. <i>Candida albicans</i>, which is the major microbe contributing to oral cancer development, may promote carcinogenesis via several mechanisms, mainly triggering inflammation. Early detection of pancreatic cancer provides the opportunity to improve survival rate, therefore, there is a need to conduct further studies regarding the role of fungal microbiota as a potential prognostic tool to diagnose this cancer at early stage. Additionally, growing attention towards the characterization of mycobiota may contribute to improve the efficiency of therapeutic methods used to alter the composition and activity of gut microbiota. The administration of <i>Saccharomyces boulardii</i> in oncology, mainly in immunocompromised and/or critically ill patients, is still controversial.https://www.mdpi.com/2072-6694/12/5/1326mycobiotacolorectal canceroral cancerpancreatic cancergut microbiota<i>Saccharomyces boulardii</i> |
| spellingShingle | Karolina Kaźmierczak-Siedlecka Aleš Dvořák Marcin Folwarski Agnieszka Daca Katarzyna Przewłócka Wojciech Makarewicz Fungal Gut Microbiota Dysbiosis and Its Role in Colorectal, Oral, and Pancreatic Carcinogenesis Cancers mycobiota colorectal cancer oral cancer pancreatic cancer gut microbiota <i>Saccharomyces boulardii</i> |
| title | Fungal Gut Microbiota Dysbiosis and Its Role in Colorectal, Oral, and Pancreatic Carcinogenesis |
| title_full | Fungal Gut Microbiota Dysbiosis and Its Role in Colorectal, Oral, and Pancreatic Carcinogenesis |
| title_fullStr | Fungal Gut Microbiota Dysbiosis and Its Role in Colorectal, Oral, and Pancreatic Carcinogenesis |
| title_full_unstemmed | Fungal Gut Microbiota Dysbiosis and Its Role in Colorectal, Oral, and Pancreatic Carcinogenesis |
| title_short | Fungal Gut Microbiota Dysbiosis and Its Role in Colorectal, Oral, and Pancreatic Carcinogenesis |
| title_sort | fungal gut microbiota dysbiosis and its role in colorectal oral and pancreatic carcinogenesis |
| topic | mycobiota colorectal cancer oral cancer pancreatic cancer gut microbiota <i>Saccharomyces boulardii</i> |
| url | https://www.mdpi.com/2072-6694/12/5/1326 |
| work_keys_str_mv | AT karolinakazmierczaksiedlecka fungalgutmicrobiotadysbiosisanditsroleincolorectaloralandpancreaticcarcinogenesis AT alesdvorak fungalgutmicrobiotadysbiosisanditsroleincolorectaloralandpancreaticcarcinogenesis AT marcinfolwarski fungalgutmicrobiotadysbiosisanditsroleincolorectaloralandpancreaticcarcinogenesis AT agnieszkadaca fungalgutmicrobiotadysbiosisanditsroleincolorectaloralandpancreaticcarcinogenesis AT katarzynaprzewłocka fungalgutmicrobiotadysbiosisanditsroleincolorectaloralandpancreaticcarcinogenesis AT wojciechmakarewicz fungalgutmicrobiotadysbiosisanditsroleincolorectaloralandpancreaticcarcinogenesis |