Optimization and In Vitro Characterization of Telmisartan Loaded Sodium Alginate Beads and Its In Vivo Efficacy Investigation in Hypertensive Induced Animal Model

Optimization and In Vitro Characterization of Telmisartan Loaded Sodium Alginate Beads and Its In Vivo Efficacy Investigation in Hypertensive Induced Animal Model

Background: Antihypertensive drug telmisartan (TEL) belongs to BCS class II, which is characterized by low water solubility and, consequently, low oral bioavailability. Gastroretentive systems may overcome the problems associated with low solubility of TEL and incomplete absorption by localizing the...

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Bibliographic Details
Main Authors: Ubaidulla Uthumansha, Kousalya Prabahar, Dilli Bhai Gajapathy, Mohamed El-Sherbiny, Nehal Elsherbiny, Mona Qushawy
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceutics
Subjects:
telmisartan (TEL)
gastroretentive beads
bioavailability
central composite design
in vitro buoyancy
anti-hypertension
Online Access:https://www.mdpi.com/1999-4923/15/2/709

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