Therapeutic Potential of Alpha-1 Antitrypsin in Type 1 and Type 2 Diabetes Mellitus
Alpha-1 antitrypsin (AAT) has established anti-inflammatory and immunomodulatory effects in chronic obstructive pulmonary disease but there is increasing evidence of its role in other inflammatory and immune-mediated conditions, like diabetes mellitus (DM). AAT activity is altered in both developing...
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| Định dạng: | Bài viết |
| Ngôn ngữ: | English |
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MDPI AG
2021-04-01
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| Loạt: | Medicina |
| Những chủ đề: | |
| Truy cập trực tuyến: | https://www.mdpi.com/1648-9144/57/4/397 |
| _version_ | 1827694723289055232 |
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| author | Sangmi S. Park Romy Rodriguez Ortega Christina W. Agudelo Jessica Perez Perez Brais Perez Gandara Itsaso Garcia-Arcos Cormac McCarthy Patrick Geraghty |
| author_facet | Sangmi S. Park Romy Rodriguez Ortega Christina W. Agudelo Jessica Perez Perez Brais Perez Gandara Itsaso Garcia-Arcos Cormac McCarthy Patrick Geraghty |
| author_sort | Sangmi S. Park |
| collection | DOAJ |
| description | Alpha-1 antitrypsin (AAT) has established anti-inflammatory and immunomodulatory effects in chronic obstructive pulmonary disease but there is increasing evidence of its role in other inflammatory and immune-mediated conditions, like diabetes mellitus (DM). AAT activity is altered in both developing and established type 1 diabetes mellitus (T1DM) as well in established type 2 DM (T2DM). Augmentation therapy with AAT appears to favorably impact T1DM development in mice models and to affect β-cell function and inflammation in humans with T1DM. The role of AAT in T2DM is less clear, but AAT activity appears to be reduced in T2DM. This article reviews these associations and emerging therapeutic strategies using AAT to treat DM. |
| first_indexed | 2024-03-10T12:10:50Z |
| format | Article |
| id | doaj.art-abc2d0ba95ba4a9ea23ecf6512a0db17 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T12:10:50Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-abc2d0ba95ba4a9ea23ecf6512a0db172023-11-21T16:15:30ZengMDPI AGMedicina1010-660X1648-91442021-04-0157439710.3390/medicina57040397Therapeutic Potential of Alpha-1 Antitrypsin in Type 1 and Type 2 Diabetes MellitusSangmi S. Park0Romy Rodriguez Ortega1Christina W. Agudelo2Jessica Perez Perez3Brais Perez Gandara4Itsaso Garcia-Arcos5Cormac McCarthy6Patrick Geraghty7Department of Medicine, State University of New York Downstate Health Sciences University, Brooklyn, NY 11203, USADepartment of Medicine, State University of New York Downstate Health Sciences University, Brooklyn, NY 11203, USADepartment of Medicine, State University of New York Downstate Health Sciences University, Brooklyn, NY 11203, USADepartment of Medicine, State University of New York Downstate Health Sciences University, Brooklyn, NY 11203, USADepartment of Medicine, State University of New York Downstate Health Sciences University, Brooklyn, NY 11203, USADepartment of Medicine, State University of New York Downstate Health Sciences University, Brooklyn, NY 11203, USAUniversity College Dublin School of Medicine, Education and Research Centre, St. Vincent’s University Hospital, D04 T6F4 Dublin, IrelandDepartment of Medicine, State University of New York Downstate Health Sciences University, Brooklyn, NY 11203, USAAlpha-1 antitrypsin (AAT) has established anti-inflammatory and immunomodulatory effects in chronic obstructive pulmonary disease but there is increasing evidence of its role in other inflammatory and immune-mediated conditions, like diabetes mellitus (DM). AAT activity is altered in both developing and established type 1 diabetes mellitus (T1DM) as well in established type 2 DM (T2DM). Augmentation therapy with AAT appears to favorably impact T1DM development in mice models and to affect β-cell function and inflammation in humans with T1DM. The role of AAT in T2DM is less clear, but AAT activity appears to be reduced in T2DM. This article reviews these associations and emerging therapeutic strategies using AAT to treat DM.https://www.mdpi.com/1648-9144/57/4/397alpha-1 antitrypsindiabetes mellitusinflammationapoptosis |
| spellingShingle | Sangmi S. Park Romy Rodriguez Ortega Christina W. Agudelo Jessica Perez Perez Brais Perez Gandara Itsaso Garcia-Arcos Cormac McCarthy Patrick Geraghty Therapeutic Potential of Alpha-1 Antitrypsin in Type 1 and Type 2 Diabetes Mellitus Medicina alpha-1 antitrypsin diabetes mellitus inflammation apoptosis |
| title | Therapeutic Potential of Alpha-1 Antitrypsin in Type 1 and Type 2 Diabetes Mellitus |
| title_full | Therapeutic Potential of Alpha-1 Antitrypsin in Type 1 and Type 2 Diabetes Mellitus |
| title_fullStr | Therapeutic Potential of Alpha-1 Antitrypsin in Type 1 and Type 2 Diabetes Mellitus |
| title_full_unstemmed | Therapeutic Potential of Alpha-1 Antitrypsin in Type 1 and Type 2 Diabetes Mellitus |
| title_short | Therapeutic Potential of Alpha-1 Antitrypsin in Type 1 and Type 2 Diabetes Mellitus |
| title_sort | therapeutic potential of alpha 1 antitrypsin in type 1 and type 2 diabetes mellitus |
| topic | alpha-1 antitrypsin diabetes mellitus inflammation apoptosis |
| url | https://www.mdpi.com/1648-9144/57/4/397 |
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