Prevalence and characteristics of sellar masses in the city of Al Ain, United Arab Emirates: 2011 to 2016
BACKGROUND: The prevalence of sellar masses (SMs) is reported in Europe and North America but only limited data are available from the Middle East and North Africa (MENA) region. OBJECTIVES: Assess the prevalence and characteristics of SMs in Al Ain city, United Arab Emirates. DESIGN: Retrospective,...
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| Format: | Article |
| Language: | English |
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King Faisal Specialist Hospital and Research Centre
2020-03-01
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| Series: | Annals of Saudi Medicine |
| Online Access: | https://www.annsaudimed.net/doi/full/10.5144/0256-4947.2020.105 |
| _version_ | 1818899229748232192 |
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| author | Khaled M. Aldahmani Jayadevan Sreedharan Mohamad Milad Ismail Jim Philip Satish Chandrasekhar Nair Mohammad Alfelasi Waseem Aziz Syed Ali Imran Juma Alkaabi |
| author_facet | Khaled M. Aldahmani Jayadevan Sreedharan Mohamad Milad Ismail Jim Philip Satish Chandrasekhar Nair Mohammad Alfelasi Waseem Aziz Syed Ali Imran Juma Alkaabi |
| author_sort | Khaled M. Aldahmani |
| collection | DOAJ |
| description | BACKGROUND: The prevalence of sellar masses (SMs) is reported in Europe and North America but only limited data are available from the Middle East and North Africa (MENA) region. OBJECTIVES: Assess the prevalence and characteristics of SMs in Al Ain city, United Arab Emirates. DESIGN: Retrospective, descriptive multicenter study. SETTING: Three endocrine centers in Al Ain. PATIENTS AND METHODS: All patients diagnosed with SMs in the city of Al Ain, Emirate of Abu Dhabi, between 2011 and 2016 were evaluated. Cases were identified using ICD 9 and 10 codes and demographic and clinical data were collected. The prevalence rate was calculated for patients alive and residing in Al Ain city until 31 December 2016. MAIN OUTCOME MEASURES: Clinical presentations and prevalence rate. SAMPLE SIZE: 272. RESULTS: The mean (SD) age on presentation was 40.8 (14.3) years (range: 6-114 years, median: 40.0). The 170 (61.8%) females and 128 (46.5%) were native citizens of the United Arab Emirates. Two hundred and forty five (90%) patients had pituitary adenomas (PAs) while 27 (10%) had non-pituitary sellar lesions. The four most common SMs were prolactinoma (n=139, 51.1%), nonfunctioning adenoma (NFA) (n= 69, 25.4%), somatotroph adenoma (n=32, 11.8%) and craniopharyngioma (n=15, 5.5%). Patients with prolactinoma, corticotroph adenoma, and Rathke’s cleft cyst had small sellar masses (<1 centimeter) while the majority of patients with other SMs had macroadenomas. Hypogonadism and growth hormone deficiency was present in 41.8% and 20.5% of the patients, respectively. Of 268 patients with available data, 82 patients underwent surgery while 25 patients received radiotherapy. At the end of 2016, 197 patients were residing in Al Ain city. The overall prevalence of SMs was 25.7/100 000 with PAs constituting most of these masses (n=177) for a prevalence of 23.1/100 000. CONCLUSIONS: This is the first study of SMs in the United Arab Emirates and the MENA region. Prolactinoma and NFA were the two most common SMs. Further studies are needed to explore the reasons for the lower prevalence of SMs in our region compared with other countries. LIMITATIONS: Retrospective design, relatively small sample size. CONFLICT OF INTEREST: None. |
| first_indexed | 2024-12-19T19:44:39Z |
| format | Article |
| id | doaj.art-abc325854bdf4b5bb20456c3ad06ddad |
| institution | Directory Open Access Journal |
| issn | 0256-4947 0975-4466 |
| language | English |
| last_indexed | 2024-12-19T19:44:39Z |
| publishDate | 2020-03-01 |
| publisher | King Faisal Specialist Hospital and Research Centre |
| record_format | Article |
| series | Annals of Saudi Medicine |
| spelling | doaj.art-abc325854bdf4b5bb20456c3ad06ddad2022-12-21T20:08:09ZengKing Faisal Specialist Hospital and Research CentreAnnals of Saudi Medicine0256-49470975-44662020-03-0140210511210.5144/0256-4947.2020.10510.5144_0256-4947.2020.105Prevalence and characteristics of sellar masses in the city of Al Ain, United Arab Emirates: 2011 to 2016Khaled M. Aldahmani0Jayadevan Sreedharan1Mohamad Milad Ismail2Jim Philip3Satish Chandrasekhar Nair4Mohammad Alfelasi5Waseem Aziz6Syed Ali Imran7Juma Alkaabi8From the Division of Endocrinology, Tawam Hospital, Al Ain, Abu Dhabi, United Arab EmiratesFrom the College of Medicine, Gulf Medical University, Ajman, United Arab EmiratesFrom the Division of Endocrinology, Al Ain Hospital, Al Ain, Abu Dhabi, United Arab EmiratesFrom the Division of Endocrinology, New Medical Center, Al Ain, United Arab EmiratesFrom the Academic Affairs, Tawam Hospital, Al Ain, Abu Dhabi, United Arab EmiratesFrom the Division of Ear, Nose and Throat Surgery, Tawam Hospital, Al Ain, Abu Dhabi, United Arab EmiratesFrom the Department of Neurosurgery, Mediclinic, Al Ain, United Arab EmiratesFrom the Division of Endocrinology and Metabolism, Dalhousie University, Halifax, Nova Scotia, CanadaFrom the Department of Medicine, United Arab Emirates University, Al Ain, Abu Dhabi, United Arab EmiratesBACKGROUND: The prevalence of sellar masses (SMs) is reported in Europe and North America but only limited data are available from the Middle East and North Africa (MENA) region. OBJECTIVES: Assess the prevalence and characteristics of SMs in Al Ain city, United Arab Emirates. DESIGN: Retrospective, descriptive multicenter study. SETTING: Three endocrine centers in Al Ain. PATIENTS AND METHODS: All patients diagnosed with SMs in the city of Al Ain, Emirate of Abu Dhabi, between 2011 and 2016 were evaluated. Cases were identified using ICD 9 and 10 codes and demographic and clinical data were collected. The prevalence rate was calculated for patients alive and residing in Al Ain city until 31 December 2016. MAIN OUTCOME MEASURES: Clinical presentations and prevalence rate. SAMPLE SIZE: 272. RESULTS: The mean (SD) age on presentation was 40.8 (14.3) years (range: 6-114 years, median: 40.0). The 170 (61.8%) females and 128 (46.5%) were native citizens of the United Arab Emirates. Two hundred and forty five (90%) patients had pituitary adenomas (PAs) while 27 (10%) had non-pituitary sellar lesions. The four most common SMs were prolactinoma (n=139, 51.1%), nonfunctioning adenoma (NFA) (n= 69, 25.4%), somatotroph adenoma (n=32, 11.8%) and craniopharyngioma (n=15, 5.5%). Patients with prolactinoma, corticotroph adenoma, and Rathke’s cleft cyst had small sellar masses (<1 centimeter) while the majority of patients with other SMs had macroadenomas. Hypogonadism and growth hormone deficiency was present in 41.8% and 20.5% of the patients, respectively. Of 268 patients with available data, 82 patients underwent surgery while 25 patients received radiotherapy. At the end of 2016, 197 patients were residing in Al Ain city. The overall prevalence of SMs was 25.7/100 000 with PAs constituting most of these masses (n=177) for a prevalence of 23.1/100 000. CONCLUSIONS: This is the first study of SMs in the United Arab Emirates and the MENA region. Prolactinoma and NFA were the two most common SMs. Further studies are needed to explore the reasons for the lower prevalence of SMs in our region compared with other countries. LIMITATIONS: Retrospective design, relatively small sample size. CONFLICT OF INTEREST: None.https://www.annsaudimed.net/doi/full/10.5144/0256-4947.2020.105 |
| spellingShingle | Khaled M. Aldahmani Jayadevan Sreedharan Mohamad Milad Ismail Jim Philip Satish Chandrasekhar Nair Mohammad Alfelasi Waseem Aziz Syed Ali Imran Juma Alkaabi Prevalence and characteristics of sellar masses in the city of Al Ain, United Arab Emirates: 2011 to 2016 Annals of Saudi Medicine |
| title | Prevalence and characteristics of sellar masses in the city of Al Ain, United Arab Emirates: 2011 to 2016 |
| title_full | Prevalence and characteristics of sellar masses in the city of Al Ain, United Arab Emirates: 2011 to 2016 |
| title_fullStr | Prevalence and characteristics of sellar masses in the city of Al Ain, United Arab Emirates: 2011 to 2016 |
| title_full_unstemmed | Prevalence and characteristics of sellar masses in the city of Al Ain, United Arab Emirates: 2011 to 2016 |
| title_short | Prevalence and characteristics of sellar masses in the city of Al Ain, United Arab Emirates: 2011 to 2016 |
| title_sort | prevalence and characteristics of sellar masses in the city of al ain united arab emirates 2011 to 2016 |
| url | https://www.annsaudimed.net/doi/full/10.5144/0256-4947.2020.105 |
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