Extracellular Matrix is an Important Component of Limbal Stem Cell Niche
Extracellular matrix plays an important role in stem cell niche which maintains the undifferentiated stem cell phenotype. Human corneal epithelial stem cells are presumed to reside mainly at the limbal basal epithelium. Efforts have been made to characterize different components of the extracellular...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-12-01
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| Series: | Journal of Functional Biomaterials |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2079-4983/3/4/879 |
| _version_ | 1818015094440722432 |
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| author | Sophie X. Deng Hua Mei Sheyla Gonzalez |
| author_facet | Sophie X. Deng Hua Mei Sheyla Gonzalez |
| author_sort | Sophie X. Deng |
| collection | DOAJ |
| description | Extracellular matrix plays an important role in stem cell niche which maintains the undifferentiated stem cell phenotype. Human corneal epithelial stem cells are presumed to reside mainly at the limbal basal epithelium. Efforts have been made to characterize different components of the extracellular matrix that are preferentially expressed at the limbus. Mounting evidence from experimental data suggest that these components are part of the stem cell niche and play a role in the homeostasis of limbal stem cells. The extracellular matrix provides a mechanical and structural support as well as regulates cellular functions such as adhesion, migration, proliferation, self-renewal and differentiation. Optimization of the extracellular matrix components might be able to recreate an ex vivo stem cell niche to expand limbal stem cells. |
| first_indexed | 2024-04-14T06:53:35Z |
| format | Article |
| id | doaj.art-abc3d25aae0e44e7a27e4b1d2ca5f171 |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-04-14T06:53:35Z |
| publishDate | 2012-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-abc3d25aae0e44e7a27e4b1d2ca5f1712022-12-22T02:06:58ZengMDPI AGJournal of Functional Biomaterials2079-49832012-12-013487989410.3390/jfb3040879Extracellular Matrix is an Important Component of Limbal Stem Cell NicheSophie X. DengHua MeiSheyla GonzalezExtracellular matrix plays an important role in stem cell niche which maintains the undifferentiated stem cell phenotype. Human corneal epithelial stem cells are presumed to reside mainly at the limbal basal epithelium. Efforts have been made to characterize different components of the extracellular matrix that are preferentially expressed at the limbus. Mounting evidence from experimental data suggest that these components are part of the stem cell niche and play a role in the homeostasis of limbal stem cells. The extracellular matrix provides a mechanical and structural support as well as regulates cellular functions such as adhesion, migration, proliferation, self-renewal and differentiation. Optimization of the extracellular matrix components might be able to recreate an ex vivo stem cell niche to expand limbal stem cells.http://www.mdpi.com/2079-4983/3/4/879extracellular matrixstem cell nichelimbal stem celllimbus |
| spellingShingle | Sophie X. Deng Hua Mei Sheyla Gonzalez Extracellular Matrix is an Important Component of Limbal Stem Cell Niche Journal of Functional Biomaterials extracellular matrix stem cell niche limbal stem cell limbus |
| title | Extracellular Matrix is an Important Component of Limbal Stem Cell Niche |
| title_full | Extracellular Matrix is an Important Component of Limbal Stem Cell Niche |
| title_fullStr | Extracellular Matrix is an Important Component of Limbal Stem Cell Niche |
| title_full_unstemmed | Extracellular Matrix is an Important Component of Limbal Stem Cell Niche |
| title_short | Extracellular Matrix is an Important Component of Limbal Stem Cell Niche |
| title_sort | extracellular matrix is an important component of limbal stem cell niche |
| topic | extracellular matrix stem cell niche limbal stem cell limbus |
| url | http://www.mdpi.com/2079-4983/3/4/879 |
| work_keys_str_mv | AT sophiexdeng extracellularmatrixisanimportantcomponentoflimbalstemcellniche AT huamei extracellularmatrixisanimportantcomponentoflimbalstemcellniche AT sheylagonzalez extracellularmatrixisanimportantcomponentoflimbalstemcellniche |