Insulin Like Growth Factor Binding Protein 7 as a Novel Diagnostic Marker in Sera of Iraqi Patients with Acromegaly
The purpose of this study was to measure serum levels of insulin-like growth factor-binding protein (IGFBP7), Insulin-like Growth Factor 1 (IGF-1), Growth Hormone (GH), Interleukin 6 (IL-6) and insulin in acromegaly patients and healthy controls. The acromegaly group had 60 patients, while the popu...
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| Format: | Article |
| Language: | Arabic |
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College of Science for Women, University of Baghdad
2023-06-01
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| Series: | Baghdad Science Journal |
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| Online Access: | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7797 |
| _version_ | 1797792245276999680 |
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| author | Layla Othman Farhan Baydaa Ahmed Abed Kashtl Ghasaq J. Isam Noori Salman |
| author_facet | Layla Othman Farhan Baydaa Ahmed Abed Kashtl Ghasaq J. Isam Noori Salman |
| author_sort | Layla Othman Farhan |
| collection | DOAJ |
| description |
The purpose of this study was to measure serum levels of insulin-like growth factor-binding protein (IGFBP7), Insulin-like Growth Factor 1 (IGF-1), Growth Hormone (GH), Interleukin 6 (IL-6) and insulin in acromegaly patients and healthy controls. The acromegaly group had 60 patients, while the population group had 30 people who had never had acromegaly before. The concentration of IGFBP7, IGF-1, GH, IL-6, and insulin were determined. The results of the present study indicate that IGFBP7 level in the acromegaly group was significantly lower (1.690.07 ng/mL vs. 2.740.12 ng/mL, respectively, p = 0.001). IGF-1, GH, IL-6, and insulin concentrations were also significantly higher in acromegaly patients. The diagnostic accuracy (2.194) was excellent in separating acromegaly from the healthy patient group, and the area under the curve (AUC = 0.871, p = 0.001). From the results of the present study, we can conclude that serum IGFBP7 can be used to distinguish acromegaly patients from healthy individuals.
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| first_indexed | 2024-03-13T02:30:26Z |
| format | Article |
| id | doaj.art-abc600ff70d147cfabeda4c538bd18eb |
| institution | Directory Open Access Journal |
| issn | 2078-8665 2411-7986 |
| language | Arabic |
| last_indexed | 2024-03-13T02:30:26Z |
| publishDate | 2023-06-01 |
| publisher | College of Science for Women, University of Baghdad |
| record_format | Article |
| series | Baghdad Science Journal |
| spelling | doaj.art-abc600ff70d147cfabeda4c538bd18eb2023-06-29T19:47:37ZaraCollege of Science for Women, University of BaghdadBaghdad Science Journal2078-86652411-79862023-06-01203(Suppl.)10.21123/bsj.2023.7797Insulin Like Growth Factor Binding Protein 7 as a Novel Diagnostic Marker in Sera of Iraqi Patients with AcromegalyLayla Othman Farhan0Baydaa Ahmed Abed1Kashtl Ghasaq J.2Isam Noori Salman3Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad, Iraq.National Diabetes Center, University of Mustansiriyah, Baghdad, Iraq.Department of Chemistry, College of Science, University of Mustansiriyah, Baghdad, Iraq.National Diabetes Center, University of Mustansiriyah, Baghdad, Iraq. The purpose of this study was to measure serum levels of insulin-like growth factor-binding protein (IGFBP7), Insulin-like Growth Factor 1 (IGF-1), Growth Hormone (GH), Interleukin 6 (IL-6) and insulin in acromegaly patients and healthy controls. The acromegaly group had 60 patients, while the population group had 30 people who had never had acromegaly before. The concentration of IGFBP7, IGF-1, GH, IL-6, and insulin were determined. The results of the present study indicate that IGFBP7 level in the acromegaly group was significantly lower (1.690.07 ng/mL vs. 2.740.12 ng/mL, respectively, p = 0.001). IGF-1, GH, IL-6, and insulin concentrations were also significantly higher in acromegaly patients. The diagnostic accuracy (2.194) was excellent in separating acromegaly from the healthy patient group, and the area under the curve (AUC = 0.871, p = 0.001). From the results of the present study, we can conclude that serum IGFBP7 can be used to distinguish acromegaly patients from healthy individuals. https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7797Acromegaly, Growth hormone, Insulin, Insulin-like Growth Factor 1, Insulin like growth factor binding protein 7 |
| spellingShingle | Layla Othman Farhan Baydaa Ahmed Abed Kashtl Ghasaq J. Isam Noori Salman Insulin Like Growth Factor Binding Protein 7 as a Novel Diagnostic Marker in Sera of Iraqi Patients with Acromegaly Baghdad Science Journal Acromegaly, Growth hormone, Insulin, Insulin-like Growth Factor 1, Insulin like growth factor binding protein 7 |
| title | Insulin Like Growth Factor Binding Protein 7 as a Novel Diagnostic Marker in Sera of Iraqi Patients with Acromegaly |
| title_full | Insulin Like Growth Factor Binding Protein 7 as a Novel Diagnostic Marker in Sera of Iraqi Patients with Acromegaly |
| title_fullStr | Insulin Like Growth Factor Binding Protein 7 as a Novel Diagnostic Marker in Sera of Iraqi Patients with Acromegaly |
| title_full_unstemmed | Insulin Like Growth Factor Binding Protein 7 as a Novel Diagnostic Marker in Sera of Iraqi Patients with Acromegaly |
| title_short | Insulin Like Growth Factor Binding Protein 7 as a Novel Diagnostic Marker in Sera of Iraqi Patients with Acromegaly |
| title_sort | insulin like growth factor binding protein 7 as a novel diagnostic marker in sera of iraqi patients with acromegaly |
| topic | Acromegaly, Growth hormone, Insulin, Insulin-like Growth Factor 1, Insulin like growth factor binding protein 7 |
| url | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/7797 |
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