LINC00839 promotes malignancy of liver cancer via binding FMNL2 under hypoxia
Abstract Liver cancer is one of the most common malignant tumors in the world and metastasis is the leading cause of death associated with liver cancer. Hypoxia is a common feature of solid tumors and enhances malignant character of cancer cells. However, the exact mechanisms involved in hypoxia-dri...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-16972-z |
| _version_ | 1798044522539646976 |
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| author | Yangyi Xie Hongsheng Lin Wei Wei Yinzhi Kong Qiaoling Fang Enran Chen Jianghua Liu Mingfen Li |
| author_facet | Yangyi Xie Hongsheng Lin Wei Wei Yinzhi Kong Qiaoling Fang Enran Chen Jianghua Liu Mingfen Li |
| author_sort | Yangyi Xie |
| collection | DOAJ |
| description | Abstract Liver cancer is one of the most common malignant tumors in the world and metastasis is the leading cause of death associated with liver cancer. Hypoxia is a common feature of solid tumors and enhances malignant character of cancer cells. However, the exact mechanisms involved in hypoxia-driven liver cancer progression and metastasis have not been well clarified so far. The aim of this study was to investigate the contribution of long non-coding RNA (lncRNA) in hypoxia promoting liver cancer progression. We screened and revealed LINC00839 as a novel hypoxia-responsive lncRNA in liver cancer. LINC00839 expression was up-regulated in liver cancer tissues and cell lines, and the patients with high LINC00839 expression had shortened overall survival. LINC00839 further overexpressed under hypoxia and promoted liver cancer cell proliferation, migration, and invasion. Mechanistically, LINC00839 bound multiple proteins that were primarily associated with the metabolism and RNA transport, and positively regulated the expression of Formin-like protein 2 (FMNL2). LINC00839 could promote hypoxia-mediated liver cancer progression, suggesting it may be a clinically valuable biomarker and serve as a molecular target for the diagnosis, prognosis, and therapy of liver cancer. |
| first_indexed | 2024-04-11T23:05:36Z |
| format | Article |
| id | doaj.art-abc681b872f243358feb5223d76e5821 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T23:05:36Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-abc681b872f243358feb5223d76e58212022-12-22T03:58:02ZengNature PortfolioScientific Reports2045-23222022-11-0112111210.1038/s41598-022-16972-zLINC00839 promotes malignancy of liver cancer via binding FMNL2 under hypoxiaYangyi Xie0Hongsheng Lin1Wei Wei2Yinzhi Kong3Qiaoling Fang4Enran Chen5Jianghua Liu6Mingfen Li7Guangxi University of Chinese MedicineGuangxi University of Chinese MedicineGuangxi University of Chinese MedicineGuangxi University of Chinese MedicineGuangxi University of Chinese MedicineSchool of General Practice, Guangxi Medical UniversitySchool of General Practice, Guangxi Medical UniversityGuangxi University of Chinese MedicineAbstract Liver cancer is one of the most common malignant tumors in the world and metastasis is the leading cause of death associated with liver cancer. Hypoxia is a common feature of solid tumors and enhances malignant character of cancer cells. However, the exact mechanisms involved in hypoxia-driven liver cancer progression and metastasis have not been well clarified so far. The aim of this study was to investigate the contribution of long non-coding RNA (lncRNA) in hypoxia promoting liver cancer progression. We screened and revealed LINC00839 as a novel hypoxia-responsive lncRNA in liver cancer. LINC00839 expression was up-regulated in liver cancer tissues and cell lines, and the patients with high LINC00839 expression had shortened overall survival. LINC00839 further overexpressed under hypoxia and promoted liver cancer cell proliferation, migration, and invasion. Mechanistically, LINC00839 bound multiple proteins that were primarily associated with the metabolism and RNA transport, and positively regulated the expression of Formin-like protein 2 (FMNL2). LINC00839 could promote hypoxia-mediated liver cancer progression, suggesting it may be a clinically valuable biomarker and serve as a molecular target for the diagnosis, prognosis, and therapy of liver cancer.https://doi.org/10.1038/s41598-022-16972-z |
| spellingShingle | Yangyi Xie Hongsheng Lin Wei Wei Yinzhi Kong Qiaoling Fang Enran Chen Jianghua Liu Mingfen Li LINC00839 promotes malignancy of liver cancer via binding FMNL2 under hypoxia Scientific Reports |
| title | LINC00839 promotes malignancy of liver cancer via binding FMNL2 under hypoxia |
| title_full | LINC00839 promotes malignancy of liver cancer via binding FMNL2 under hypoxia |
| title_fullStr | LINC00839 promotes malignancy of liver cancer via binding FMNL2 under hypoxia |
| title_full_unstemmed | LINC00839 promotes malignancy of liver cancer via binding FMNL2 under hypoxia |
| title_short | LINC00839 promotes malignancy of liver cancer via binding FMNL2 under hypoxia |
| title_sort | linc00839 promotes malignancy of liver cancer via binding fmnl2 under hypoxia |
| url | https://doi.org/10.1038/s41598-022-16972-z |
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