The clinical effectiveness and cost-effectiveness of testing for cytochrome P450 polymorphisms in patients with schizophrenia treated with antipsychotics: a systematic review and economic evaluation
Objective: To determine whether testing for cytochrome P450 (CYP) polymorphisms in adults entering antipsychotic treatment for schizophrenia leads to improvement in outcomes, is useful in medical, personal or public health decision-making, and is a cost-effective use of health-care resources. Data s...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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NIHR Journals Library
2010-01-01
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| Series: | Health Technology Assessment |
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| Online Access: | https://doi.org/10.3310/hta14030 |
| _version_ | 1818272203185061888 |
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| author | N Fleeman C McLeod A Bagust S Beale A Boland Y Dundar A Jorgensen K Payne M Pirmohamed S Pushpakom T Walley P de Warren-Penny R Dickson |
| author_facet | N Fleeman C McLeod A Bagust S Beale A Boland Y Dundar A Jorgensen K Payne M Pirmohamed S Pushpakom T Walley P de Warren-Penny R Dickson |
| author_sort | N Fleeman |
| collection | DOAJ |
| description | Objective: To determine whether testing for cytochrome P450 (CYP) polymorphisms in adults entering antipsychotic treatment for schizophrenia leads to improvement in outcomes, is useful in medical, personal or public health decision-making, and is a cost-effective use of health-care resources. Data sources: The following electronic databases were searched for relevant published literature: Cochrane Controlled Trials Register, Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effectiveness, EMBASE, Health Technology Assessment database, ISI Web of Knowledge, MEDLINE, PsycINFO, NHS Economic Evaluation Database, Health Economic Evaluation Database, Cost-effectiveness Analysis (CEA) Registry and the Centre for Health Economics website. In addition, publicly available information on various genotyping tests was sought from the internet and advisory panel members. Review methods: A systematic review of analytical validity, clinical validity and clinical utility of CYP testing was undertaken. Data were extracted into structured tables and narratively discussed, and meta-analysis was undertaken when possible. A review of economic evaluations of CYP testing in psychiatry and a review of economic models related to schizophrenia were also carried out. Results: For analytical validity, 46 studies of a range of different genotyping tests for 11 different CYP polymorphisms (most commonly CYP2D6) were included. Sensitivity and specificity were high (99–100%). For clinical validity, 51 studies were found. In patients tested for CYP2D6, an association between genotype and tardive dyskinesia (including Abnormal Involuntary Movement Scale scores) was found. The only other significant finding linked the CYP2D6 genotype to parkinsonism. One small unpublished study met the inclusion criteria for clinical utility. One economic evaluation assessing the costs and benefits of CYP testing for prescribing antidepressants and 28 economic models of schizophrenia were identified; none was suitable for developing a model to examine the cost-effectiveness of CYP testing. Conclusions: Tests for determining genotypes appear to be accurate although not all aspects of analytical validity were reported. Given the absence of convincing evidence from clinical validity studies, the lack of clinical utility and economic studies, and the unsuitability of published schizophrenia models, no model was developed; instead key features and data requirements for economic modelling are presented. Recommendations for future research cover both aspects of research quality and data that will be required to inform the development of future economic models. |
| first_indexed | 2024-12-12T21:38:20Z |
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| institution | Directory Open Access Journal |
| issn | 1366-5278 2046-4924 |
| language | English |
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| publishDate | 2010-01-01 |
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| series | Health Technology Assessment |
| spelling | doaj.art-abc71c369452440b88500ecc83bfc2072022-12-22T00:11:08ZengNIHR Journals LibraryHealth Technology Assessment1366-52782046-49242010-01-0114310.3310/hta1403006/28/01The clinical effectiveness and cost-effectiveness of testing for cytochrome P450 polymorphisms in patients with schizophrenia treated with antipsychotics: a systematic review and economic evaluationN Fleeman0C McLeod1A Bagust2S Beale3A Boland4Y Dundar5A Jorgensen6K Payne7M Pirmohamed8S Pushpakom9T Walley10P de Warren-Penny11R Dickson12Liverpool Reviews and Implementation Group (LRiG), University of Liverpool, UKLiverpool Reviews and Implementation Group (LRiG), University of Liverpool, UKLiverpool Reviews and Implementation Group (LRiG), University of Liverpool, UKYork Health Economics Consortium, University of York, UKLiverpool Reviews and Implementation Group (LRiG), University of Liverpool, UKLiverpool Reviews and Implementation Group (LRiG), University of Liverpool, UKMedical Statistics, University of Liverpool, UKThe Hesketh Centre, Merseyside NHS Trust, Southport, UKDepartment of Pharmacology and Therapeutics, University of Liverpool, UKDepartment of Pharmacology and Therapeutics, University of Liverpool, UKLiverpool Reviews and Implementation Group (LRiG), University of Liverpool, UKNorth Devon District Hospital, Barnstaple, UKLiverpool Reviews and Implementation Group (LRiG), University of Liverpool, UKObjective: To determine whether testing for cytochrome P450 (CYP) polymorphisms in adults entering antipsychotic treatment for schizophrenia leads to improvement in outcomes, is useful in medical, personal or public health decision-making, and is a cost-effective use of health-care resources. Data sources: The following electronic databases were searched for relevant published literature: Cochrane Controlled Trials Register, Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effectiveness, EMBASE, Health Technology Assessment database, ISI Web of Knowledge, MEDLINE, PsycINFO, NHS Economic Evaluation Database, Health Economic Evaluation Database, Cost-effectiveness Analysis (CEA) Registry and the Centre for Health Economics website. In addition, publicly available information on various genotyping tests was sought from the internet and advisory panel members. Review methods: A systematic review of analytical validity, clinical validity and clinical utility of CYP testing was undertaken. Data were extracted into structured tables and narratively discussed, and meta-analysis was undertaken when possible. A review of economic evaluations of CYP testing in psychiatry and a review of economic models related to schizophrenia were also carried out. Results: For analytical validity, 46 studies of a range of different genotyping tests for 11 different CYP polymorphisms (most commonly CYP2D6) were included. Sensitivity and specificity were high (99–100%). For clinical validity, 51 studies were found. In patients tested for CYP2D6, an association between genotype and tardive dyskinesia (including Abnormal Involuntary Movement Scale scores) was found. The only other significant finding linked the CYP2D6 genotype to parkinsonism. One small unpublished study met the inclusion criteria for clinical utility. One economic evaluation assessing the costs and benefits of CYP testing for prescribing antidepressants and 28 economic models of schizophrenia were identified; none was suitable for developing a model to examine the cost-effectiveness of CYP testing. Conclusions: Tests for determining genotypes appear to be accurate although not all aspects of analytical validity were reported. Given the absence of convincing evidence from clinical validity studies, the lack of clinical utility and economic studies, and the unsuitability of published schizophrenia models, no model was developed; instead key features and data requirements for economic modelling are presented. Recommendations for future research cover both aspects of research quality and data that will be required to inform the development of future economic models.https://doi.org/10.3310/hta14030cytochrome-p450-polymorphismsschizophreniaantipsychoticsgenotypingpharmacogenetic-testingsystematic-revieweconomic-evaluation |
| spellingShingle | N Fleeman C McLeod A Bagust S Beale A Boland Y Dundar A Jorgensen K Payne M Pirmohamed S Pushpakom T Walley P de Warren-Penny R Dickson The clinical effectiveness and cost-effectiveness of testing for cytochrome P450 polymorphisms in patients with schizophrenia treated with antipsychotics: a systematic review and economic evaluation Health Technology Assessment cytochrome-p450-polymorphisms schizophrenia antipsychotics genotyping pharmacogenetic-testing systematic-review economic-evaluation |
| title | The clinical effectiveness and cost-effectiveness of testing for cytochrome P450 polymorphisms in patients with schizophrenia treated with antipsychotics: a systematic review and economic evaluation |
| title_full | The clinical effectiveness and cost-effectiveness of testing for cytochrome P450 polymorphisms in patients with schizophrenia treated with antipsychotics: a systematic review and economic evaluation |
| title_fullStr | The clinical effectiveness and cost-effectiveness of testing for cytochrome P450 polymorphisms in patients with schizophrenia treated with antipsychotics: a systematic review and economic evaluation |
| title_full_unstemmed | The clinical effectiveness and cost-effectiveness of testing for cytochrome P450 polymorphisms in patients with schizophrenia treated with antipsychotics: a systematic review and economic evaluation |
| title_short | The clinical effectiveness and cost-effectiveness of testing for cytochrome P450 polymorphisms in patients with schizophrenia treated with antipsychotics: a systematic review and economic evaluation |
| title_sort | clinical effectiveness and cost effectiveness of testing for cytochrome p450 polymorphisms in patients with schizophrenia treated with antipsychotics a systematic review and economic evaluation |
| topic | cytochrome-p450-polymorphisms schizophrenia antipsychotics genotyping pharmacogenetic-testing systematic-review economic-evaluation |
| url | https://doi.org/10.3310/hta14030 |
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