HDM2 antagonist MI-219 (spiro-oxindole), but not Nutlin-3 (<it>cis</it>-imidazoline), regulates p53 through enhanced HDM2 autoubiquitination and degradation in human malignant B-cell lymphomas
<p>Abstract</p> <p>Background</p> <p>Lymphomas frequently retain wild-type (wt) p53 function but overexpress HDM2, thereby compromising p53 activity. Therefore, lymphoma is a suitable model for studying the therapeutic value of disrupting the HDM2-p53 interaction by sma...
Main Authors: | Sosin Angela M, Burger Angelika M, Siddiqi Aisha, Abrams Judith, Mohammad Ramzi M, Al-Katib Ayad M |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2012-09-01
|
Series: | Journal of Hematology & Oncology |
Subjects: | |
Online Access: | http://www.jhoonline.org/content/5/1/57 |
Similar Items
-
Helping the Released Guardian: Drug Combinations for Supporting the Anticancer Activity of HDM2 (MDM2) Antagonists
by: Justyna Kocik, et al.
Published: (2019-07-01) -
Effects of 2HDM in Electroweak Phase Transition
by: Arnab Chaudhuri, et al.
Published: (2021-06-01) -
Constraining CP4 3HDM with Top Quark Decays
by: Igor P. Ivanov, et al.
Published: (2021-06-01) -
Technical, economical, and socio-environmental analysis of forest road maintenance using the HDM-4 software
by: Breno Santos Arrivabeni, et al.
Published: (2023-08-01) -
Simultaneous observation of neutral Higgs particles with different masses in 2HDM at future colliders
by: Majid Hashemi
Published: (2023-02-01)