Effects of Fatty Acid Therapy in Addition to Strong Statin on Coronary Plaques in Acute Coronary Syndrome: An Optical Coherence Tomography Study
BACKGROUND Vascular healing response associated with adjunctive n‐3 polyunsaturated fatty acid therapy therapy in patients receiving strong statin therapy remains unclear. The aim of this study was to evaluate the effect of polyunsaturated fatty acid therapy with eicosapentaenoic acid (EPA) or docos...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-08-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
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| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.119.015593 |
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| author | Yoko Kita Makoto Watanabe Daisuke Kamon Tomoya Ueda Tsunenari Soeda Satoshi Okayama Kenichi Ishigami Hiroyuki Kawata Manabu Horii Fumitaka Inoue Naofumi Doi Hiroyuki Okura Shiro Uemura Yoshihiko Saito |
| author_facet | Yoko Kita Makoto Watanabe Daisuke Kamon Tomoya Ueda Tsunenari Soeda Satoshi Okayama Kenichi Ishigami Hiroyuki Kawata Manabu Horii Fumitaka Inoue Naofumi Doi Hiroyuki Okura Shiro Uemura Yoshihiko Saito |
| author_sort | Yoko Kita |
| collection | DOAJ |
| description | BACKGROUND Vascular healing response associated with adjunctive n‐3 polyunsaturated fatty acid therapy therapy in patients receiving strong statin therapy remains unclear. The aim of this study was to evaluate the effect of polyunsaturated fatty acid therapy with eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) in addition to strong statin therapy on coronary atherosclerotic plaques using optical coherence tomography. METHODS AND RESULTS This prospective multicenter randomized controlled trial included 130 patients with acute coronary syndrome treated with strong statins. They were assigned to either statin only (control group, n=42), statin+high‐dose EPA (1800 mg/day) (EPA group, n=40), statin+EPA (930 mg/day)+DHA (750 mg/day) (EPA+DHA group, n=48). Optical coherence tomography was performed at baseline and at the 8‐month follow‐up. The target for optical coherence tomography analysis was a nonculprit lesion with a lipid plaque. Between baseline and the 8‐month follow‐up, fibrous cap thickness (FCT) significantly increased in all 3 groups. There were no significant differences in the percent change for minimum FCT between the EPA or EPA+DHA group and the control group. In patients with FCT <120 µm (median value), the percent change for minimum FCT was significantly higher in the EPA or EPA+DHA group compared with the control group. CONCLUSIONS EPA or EPA+DHA therapy in addition to strong statin therapy did not significantly increase FCT in nonculprit plaques compared with strong statin therapy alone, but significantly increased FCT in patients with thinner FCT. Registration URL: https://www.umin.ac.jp/ctr/; Unique identifier: UMIN 000012825. |
| first_indexed | 2024-12-13T12:26:29Z |
| format | Article |
| id | doaj.art-abc97ac7edfb4dca89b3b8d47b1f2e1d |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-13T12:26:29Z |
| publishDate | 2020-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-abc97ac7edfb4dca89b3b8d47b1f2e1d2022-12-21T23:46:17ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802020-08-0191610.1161/JAHA.119.015593Effects of Fatty Acid Therapy in Addition to Strong Statin on Coronary Plaques in Acute Coronary Syndrome: An Optical Coherence Tomography StudyYoko Kita0Makoto Watanabe1Daisuke Kamon2Tomoya Ueda3Tsunenari Soeda4Satoshi Okayama5Kenichi Ishigami6Hiroyuki Kawata7Manabu Horii8Fumitaka Inoue9Naofumi Doi10Hiroyuki Okura11Shiro Uemura12Yoshihiko Saito13Department of Cardiovascular Medicine Nara Medical University Kashihara JapanDepartment of Cardiovascular Medicine Nara Medical University Kashihara JapanDepartment of Cardiovascular Medicine Nara Medical University Kashihara JapanDepartment of Cardiovascular Medicine Nara Medical University Kashihara JapanDepartment of Cardiovascular Medicine Nara Medical University Kashihara JapanDepartment of Cardiovascular Medicine Nara Medical University Kashihara JapanDepartment of Cardiology Saiseikai Suita Hospital Suita JapanDepartment of Cardiovascular Medicine Nara Prefecture General Medical Center Nara JapanDepartment of Cardiovascular Medicine Nara City Hospital Nara JapanYamato Kashihara Hospital Kashihara JapanDepartment of Cardiology Nara Prefecture Seiwa Medical Center Nara JapanDepartment of Cardiology Gifu University Gradual School of Medicine Gifu JapanDivision of CardiologyKawasaki Medical School Kurashiki JapanDepartment of Cardiovascular Medicine Nara Medical University Kashihara JapanBACKGROUND Vascular healing response associated with adjunctive n‐3 polyunsaturated fatty acid therapy therapy in patients receiving strong statin therapy remains unclear. The aim of this study was to evaluate the effect of polyunsaturated fatty acid therapy with eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) in addition to strong statin therapy on coronary atherosclerotic plaques using optical coherence tomography. METHODS AND RESULTS This prospective multicenter randomized controlled trial included 130 patients with acute coronary syndrome treated with strong statins. They were assigned to either statin only (control group, n=42), statin+high‐dose EPA (1800 mg/day) (EPA group, n=40), statin+EPA (930 mg/day)+DHA (750 mg/day) (EPA+DHA group, n=48). Optical coherence tomography was performed at baseline and at the 8‐month follow‐up. The target for optical coherence tomography analysis was a nonculprit lesion with a lipid plaque. Between baseline and the 8‐month follow‐up, fibrous cap thickness (FCT) significantly increased in all 3 groups. There were no significant differences in the percent change for minimum FCT between the EPA or EPA+DHA group and the control group. In patients with FCT <120 µm (median value), the percent change for minimum FCT was significantly higher in the EPA or EPA+DHA group compared with the control group. CONCLUSIONS EPA or EPA+DHA therapy in addition to strong statin therapy did not significantly increase FCT in nonculprit plaques compared with strong statin therapy alone, but significantly increased FCT in patients with thinner FCT. Registration URL: https://www.umin.ac.jp/ctr/; Unique identifier: UMIN 000012825.https://www.ahajournals.org/doi/10.1161/JAHA.119.015593fatty acidfibrous capoptical coherence tomography |
| spellingShingle | Yoko Kita Makoto Watanabe Daisuke Kamon Tomoya Ueda Tsunenari Soeda Satoshi Okayama Kenichi Ishigami Hiroyuki Kawata Manabu Horii Fumitaka Inoue Naofumi Doi Hiroyuki Okura Shiro Uemura Yoshihiko Saito Effects of Fatty Acid Therapy in Addition to Strong Statin on Coronary Plaques in Acute Coronary Syndrome: An Optical Coherence Tomography Study Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease fatty acid fibrous cap optical coherence tomography |
| title | Effects of Fatty Acid Therapy in Addition to Strong Statin on Coronary Plaques in Acute Coronary Syndrome: An Optical Coherence Tomography Study |
| title_full | Effects of Fatty Acid Therapy in Addition to Strong Statin on Coronary Plaques in Acute Coronary Syndrome: An Optical Coherence Tomography Study |
| title_fullStr | Effects of Fatty Acid Therapy in Addition to Strong Statin on Coronary Plaques in Acute Coronary Syndrome: An Optical Coherence Tomography Study |
| title_full_unstemmed | Effects of Fatty Acid Therapy in Addition to Strong Statin on Coronary Plaques in Acute Coronary Syndrome: An Optical Coherence Tomography Study |
| title_short | Effects of Fatty Acid Therapy in Addition to Strong Statin on Coronary Plaques in Acute Coronary Syndrome: An Optical Coherence Tomography Study |
| title_sort | effects of fatty acid therapy in addition to strong statin on coronary plaques in acute coronary syndrome an optical coherence tomography study |
| topic | fatty acid fibrous cap optical coherence tomography |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.119.015593 |
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