Immune Reconstitution Inflammatory Syndrome in Acquired Immune Deficiency Syndrome related to Cryptococcal Meningoencephalitis
Background . Highly active antiretroviral therapy (HAART) has contributed to reducing the occurrence of opportunistic infections and mortality in human immunodeficiency virus (HIV) infected patients. However, a paradoxical worsening of clinical signs and symptoms among patients during HAART may occu...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2014-04-01
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| Series: | Journal of Investigative Medicine High Impact Case Reports |
| Online Access: | https://doi.org/10.1177/2324709614533951 |
| _version_ | 1819226555567570944 |
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| author | Ji Young Park MD Min Jeong Kim MD |
| author_facet | Ji Young Park MD Min Jeong Kim MD |
| author_sort | Ji Young Park MD |
| collection | DOAJ |
| description | Background . Highly active antiretroviral therapy (HAART) has contributed to reducing the occurrence of opportunistic infections and mortality in human immunodeficiency virus (HIV) infected patients. However, a paradoxical worsening of clinical signs and symptoms among patients during HAART may occur. Immune reconstitution inflammatory syndrome (IRIS) is described as a paradoxical deterioration of clinical status on initiation of HAART in patients with HIV infection. Case Report . We describe the case of a 41-year-old man with opportunistic cryptococcal encephalitis who exhibited neurological and radiological deterioration during the course of HAART. A diagnosis of central nervous system (CNS)-IRIS was based on a decrease of HIV-RNA viral load greater than 1 log, with an increase in CD4 + T-cell count from baseline. Conclusions . Differential diagnosis of this paradoxical deterioration in clinical and neurological status from overwhelming opportunistic infection is important; it enables an avoidance of unnecessary diagnostic procedures and proper management of this HIV-associated CNS disorder. |
| first_indexed | 2024-12-23T10:27:21Z |
| format | Article |
| id | doaj.art-abcb1c170eb34723928ca5ab6b44b8db |
| institution | Directory Open Access Journal |
| issn | 2324-7096 |
| language | English |
| last_indexed | 2024-12-23T10:27:21Z |
| publishDate | 2014-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Investigative Medicine High Impact Case Reports |
| spelling | doaj.art-abcb1c170eb34723928ca5ab6b44b8db2022-12-21T17:50:32ZengSAGE PublishingJournal of Investigative Medicine High Impact Case Reports2324-70962014-04-01210.1177/232470961453395110.1177_2324709614533951Immune Reconstitution Inflammatory Syndrome in Acquired Immune Deficiency Syndrome related to Cryptococcal MeningoencephalitisJi Young Park MD0Min Jeong Kim MD1Kosin University College of Medicine, Busan, KoreaKosin University College of Medicine, Busan, KoreaBackground . Highly active antiretroviral therapy (HAART) has contributed to reducing the occurrence of opportunistic infections and mortality in human immunodeficiency virus (HIV) infected patients. However, a paradoxical worsening of clinical signs and symptoms among patients during HAART may occur. Immune reconstitution inflammatory syndrome (IRIS) is described as a paradoxical deterioration of clinical status on initiation of HAART in patients with HIV infection. Case Report . We describe the case of a 41-year-old man with opportunistic cryptococcal encephalitis who exhibited neurological and radiological deterioration during the course of HAART. A diagnosis of central nervous system (CNS)-IRIS was based on a decrease of HIV-RNA viral load greater than 1 log, with an increase in CD4 + T-cell count from baseline. Conclusions . Differential diagnosis of this paradoxical deterioration in clinical and neurological status from overwhelming opportunistic infection is important; it enables an avoidance of unnecessary diagnostic procedures and proper management of this HIV-associated CNS disorder.https://doi.org/10.1177/2324709614533951 |
| spellingShingle | Ji Young Park MD Min Jeong Kim MD Immune Reconstitution Inflammatory Syndrome in Acquired Immune Deficiency Syndrome related to Cryptococcal Meningoencephalitis Journal of Investigative Medicine High Impact Case Reports |
| title | Immune Reconstitution Inflammatory Syndrome in Acquired Immune Deficiency Syndrome related to Cryptococcal Meningoencephalitis |
| title_full | Immune Reconstitution Inflammatory Syndrome in Acquired Immune Deficiency Syndrome related to Cryptococcal Meningoencephalitis |
| title_fullStr | Immune Reconstitution Inflammatory Syndrome in Acquired Immune Deficiency Syndrome related to Cryptococcal Meningoencephalitis |
| title_full_unstemmed | Immune Reconstitution Inflammatory Syndrome in Acquired Immune Deficiency Syndrome related to Cryptococcal Meningoencephalitis |
| title_short | Immune Reconstitution Inflammatory Syndrome in Acquired Immune Deficiency Syndrome related to Cryptococcal Meningoencephalitis |
| title_sort | immune reconstitution inflammatory syndrome in acquired immune deficiency syndrome related to cryptococcal meningoencephalitis |
| url | https://doi.org/10.1177/2324709614533951 |
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