Cardiac Hypertrophy and Related Dysfunctions in Cushing Syndrome Patients—Literature Review
The survival rate of adrenal Cushing syndrome patients has been greatly increased because of the availability of appropriate surgical and pharmacological treatments. Nevertheless, increased possibility of a heart attack induced by a cardiovascular event remains a major risk factor for the survival o...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-11-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/11/23/7035 |
| _version_ | 1797462953539141632 |
|---|---|
| author | Akinori Kanzaki Manabu Kadoya Satoru Katayama Hidenori Koyama |
| author_facet | Akinori Kanzaki Manabu Kadoya Satoru Katayama Hidenori Koyama |
| author_sort | Akinori Kanzaki |
| collection | DOAJ |
| description | The survival rate of adrenal Cushing syndrome patients has been greatly increased because of the availability of appropriate surgical and pharmacological treatments. Nevertheless, increased possibility of a heart attack induced by a cardiovascular event remains a major risk factor for the survival of affected patients. In experimental studies, hypercortisolemia has been found to cause cardiomyocyte hypertrophy via glucocorticoid receptor activation, including the possibility of cross talk among several hypertrophy signals related to cardiomyocytes and tissue-dependent regulation of 11β-hydroxysteroid dehydrogenase type 1. However, the factors are more complex in clinical cases, as both geometric and functional impairments leading to heart failure have been revealed, and their associations with a wide range of factors such as hypertension are crucial. In addition, knowledge regarding such alterations in autonomous cortisol secretion, which has a high risk of leading to heart attack as well as overt Cushing syndrome, is quite limited. When considering the effects of treatment, partial improvement of structural alterations is expected, while functional disorders are controversial. Therefore, whether the normalization of excess cortisol attenuates the risk related to cardiac hypertrophy has yet to be fully elucidated. |
| first_indexed | 2024-03-09T17:43:50Z |
| format | Article |
| id | doaj.art-abcb6fcaeab0472da3c1014eda1896cd |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T17:43:50Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-abcb6fcaeab0472da3c1014eda1896cd2023-11-24T11:21:50ZengMDPI AGJournal of Clinical Medicine2077-03832022-11-011123703510.3390/jcm11237035Cardiac Hypertrophy and Related Dysfunctions in Cushing Syndrome Patients—Literature ReviewAkinori Kanzaki0Manabu Kadoya1Satoru Katayama2Hidenori Koyama3Department of Internal Medicine, Hyogo College of Medicine, Sasayama Medical Center, Sasayama 669-2321, Hyogo, JapanDepartment of Diabetes, Endocrinology and Clinical Immunology, Hyogo College of Medicine, Nishinomiya 663-8131, Hyogo, JapanDepartment of Internal Medicine, Hyogo College of Medicine, Sasayama Medical Center, Sasayama 669-2321, Hyogo, JapanDepartment of Diabetes, Endocrinology and Clinical Immunology, Hyogo College of Medicine, Nishinomiya 663-8131, Hyogo, JapanThe survival rate of adrenal Cushing syndrome patients has been greatly increased because of the availability of appropriate surgical and pharmacological treatments. Nevertheless, increased possibility of a heart attack induced by a cardiovascular event remains a major risk factor for the survival of affected patients. In experimental studies, hypercortisolemia has been found to cause cardiomyocyte hypertrophy via glucocorticoid receptor activation, including the possibility of cross talk among several hypertrophy signals related to cardiomyocytes and tissue-dependent regulation of 11β-hydroxysteroid dehydrogenase type 1. However, the factors are more complex in clinical cases, as both geometric and functional impairments leading to heart failure have been revealed, and their associations with a wide range of factors such as hypertension are crucial. In addition, knowledge regarding such alterations in autonomous cortisol secretion, which has a high risk of leading to heart attack as well as overt Cushing syndrome, is quite limited. When considering the effects of treatment, partial improvement of structural alterations is expected, while functional disorders are controversial. Therefore, whether the normalization of excess cortisol attenuates the risk related to cardiac hypertrophy has yet to be fully elucidated.https://www.mdpi.com/2077-0383/11/23/7035adrenal tumorautonomous cortisol secretioncardiac functional disordercardiac hypertrophycardiomyocytesCushing syndrome |
| spellingShingle | Akinori Kanzaki Manabu Kadoya Satoru Katayama Hidenori Koyama Cardiac Hypertrophy and Related Dysfunctions in Cushing Syndrome Patients—Literature Review Journal of Clinical Medicine adrenal tumor autonomous cortisol secretion cardiac functional disorder cardiac hypertrophy cardiomyocytes Cushing syndrome |
| title | Cardiac Hypertrophy and Related Dysfunctions in Cushing Syndrome Patients—Literature Review |
| title_full | Cardiac Hypertrophy and Related Dysfunctions in Cushing Syndrome Patients—Literature Review |
| title_fullStr | Cardiac Hypertrophy and Related Dysfunctions in Cushing Syndrome Patients—Literature Review |
| title_full_unstemmed | Cardiac Hypertrophy and Related Dysfunctions in Cushing Syndrome Patients—Literature Review |
| title_short | Cardiac Hypertrophy and Related Dysfunctions in Cushing Syndrome Patients—Literature Review |
| title_sort | cardiac hypertrophy and related dysfunctions in cushing syndrome patients literature review |
| topic | adrenal tumor autonomous cortisol secretion cardiac functional disorder cardiac hypertrophy cardiomyocytes Cushing syndrome |
| url | https://www.mdpi.com/2077-0383/11/23/7035 |
| work_keys_str_mv | AT akinorikanzaki cardiachypertrophyandrelateddysfunctionsincushingsyndromepatientsliteraturereview AT manabukadoya cardiachypertrophyandrelateddysfunctionsincushingsyndromepatientsliteraturereview AT satorukatayama cardiachypertrophyandrelateddysfunctionsincushingsyndromepatientsliteraturereview AT hidenorikoyama cardiachypertrophyandrelateddysfunctionsincushingsyndromepatientsliteraturereview |