Unraveling the impact of disrupted nucleocytoplasmic transport systems in C9orf72-associated ALS

Unraveling the impact of disrupted nucleocytoplasmic transport systems in C9orf72-associated ALS

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two adult-onset neurodegenerative diseases that are part of a common disease spectrum due to clinical, genetic, and pathological overlap. A prominent genetic factor contributing to both diseases is a hexanucleotide repeat expa...

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Bibliographic Details
Main Authors:	Philip McGoldrick, Janice Robertson
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-08-01
Series:	Frontiers in Cellular Neuroscience
Subjects:	amyotrophic lateral sclerosis (ALS) frontotemporal dementia (FTD) C9orf72 Ran-GTP nuclear pore complex (NPC) nucleocytoplasmic transport
Online Access:	https://www.frontiersin.org/articles/10.3389/fncel.2023.1247297/full

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