Causal role of immune cells in psoriasis: a Mendelian randomization analysis
BackgroundA growing body of evidence has shown that immune cells are linked to psoriasis. It is, however, still unclear if these associations reflect a relationship of cause and effect.ObjectiveWe employed a two-sample Mendelian randomization (MR)-based study to elucidate the probable causative conn...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1326717/full |
| _version_ | 1797261795111469056 |
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| author | Anning Wang Jingyuan Zhang |
| author_facet | Anning Wang Jingyuan Zhang |
| author_sort | Anning Wang |
| collection | DOAJ |
| description | BackgroundA growing body of evidence has shown that immune cells are linked to psoriasis. It is, however, still unclear if these associations reflect a relationship of cause and effect.ObjectiveWe employed a two-sample Mendelian randomization (MR)-based study to elucidate the probable causative connection between immune cells and psoriasis.MethodsSummary information for psoriasis (Ncase = 5,427, Ncontrol = 479,171) was obtained from the European Bioinformatics Institute. Summarized statistical information on 731 immune cell features, including morphological parameters (MP; n = 32), relative cell number (n = 192), median fluorescence intensity (MFI) of surface antigens (n = 389), and absolute cell number (n = 118), was obtained from the genome-wide association studies (GWAS) catalog. The research consisted of forward MR analysis, in which immune cell traits were used as the exposure factor, and psoriasis was the outcome, as well as reverse MR analysis, in which psoriasis was used as the exposure factor, and immune cell traits were the outcome. We ran numerous sensitivity analyses to ascertain the study results for robustness, heterogeneity, and potential multiple-biological effects.ResultThis research determined a probable causative connection between immune cells and psoriasis. In particular, we identified 36 distinct types of immune cells that are potentially causally linked to psoriasis.ConclusionOur findings indicate strong causal correlations between 36 immunological phenotypes and psoriasis, thus, directing future clinical trials. |
| first_indexed | 2024-04-24T23:46:53Z |
| format | Article |
| id | doaj.art-abcd465a8f3049d4ab81295a0a2a7a48 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-24T23:46:53Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-abcd465a8f3049d4ab81295a0a2a7a482024-03-15T04:58:05ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-03-011510.3389/fimmu.2024.13267171326717Causal role of immune cells in psoriasis: a Mendelian randomization analysisAnning Wang0Jingyuan Zhang1Dalian Dermatosis Hospital, Dalian, Liaoning, ChinaDepartment of Traditional Chinese Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, ChinaBackgroundA growing body of evidence has shown that immune cells are linked to psoriasis. It is, however, still unclear if these associations reflect a relationship of cause and effect.ObjectiveWe employed a two-sample Mendelian randomization (MR)-based study to elucidate the probable causative connection between immune cells and psoriasis.MethodsSummary information for psoriasis (Ncase = 5,427, Ncontrol = 479,171) was obtained from the European Bioinformatics Institute. Summarized statistical information on 731 immune cell features, including morphological parameters (MP; n = 32), relative cell number (n = 192), median fluorescence intensity (MFI) of surface antigens (n = 389), and absolute cell number (n = 118), was obtained from the genome-wide association studies (GWAS) catalog. The research consisted of forward MR analysis, in which immune cell traits were used as the exposure factor, and psoriasis was the outcome, as well as reverse MR analysis, in which psoriasis was used as the exposure factor, and immune cell traits were the outcome. We ran numerous sensitivity analyses to ascertain the study results for robustness, heterogeneity, and potential multiple-biological effects.ResultThis research determined a probable causative connection between immune cells and psoriasis. In particular, we identified 36 distinct types of immune cells that are potentially causally linked to psoriasis.ConclusionOur findings indicate strong causal correlations between 36 immunological phenotypes and psoriasis, thus, directing future clinical trials.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1326717/fullMendelian randomizationpsoriasisimmune cellsT cellB cell |
| spellingShingle | Anning Wang Jingyuan Zhang Causal role of immune cells in psoriasis: a Mendelian randomization analysis Frontiers in Immunology Mendelian randomization psoriasis immune cells T cell B cell |
| title | Causal role of immune cells in psoriasis: a Mendelian randomization analysis |
| title_full | Causal role of immune cells in psoriasis: a Mendelian randomization analysis |
| title_fullStr | Causal role of immune cells in psoriasis: a Mendelian randomization analysis |
| title_full_unstemmed | Causal role of immune cells in psoriasis: a Mendelian randomization analysis |
| title_short | Causal role of immune cells in psoriasis: a Mendelian randomization analysis |
| title_sort | causal role of immune cells in psoriasis a mendelian randomization analysis |
| topic | Mendelian randomization psoriasis immune cells T cell B cell |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1326717/full |
| work_keys_str_mv | AT anningwang causalroleofimmunecellsinpsoriasisamendelianrandomizationanalysis AT jingyuanzhang causalroleofimmunecellsinpsoriasisamendelianrandomizationanalysis |