Beneficial effects of folic acid fortification in the prevention of Spina Bifida and reducing the orthopaedic procedures: A narrative review of the current literature
Background: Spina bifida (SB) is a neural tube defect that affects more than 200,000 pregnancies globally. Folic acid fortification has been shown to be the most effective public health strategy to prevent SB. Patients with SB require surgical and non-surgical orthopaedic care to correct a variety o...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Journal of Orthopaedic Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2773157X23000474 |
| _version_ | 1797669723241971712 |
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| author | Priyanka K. Mathur Pooja Dave Samuel I. Fuller Kendrick Cuero Anthony Chiu Aribah Shah Gail L. Rosseau John F. Sarwark |
| author_facet | Priyanka K. Mathur Pooja Dave Samuel I. Fuller Kendrick Cuero Anthony Chiu Aribah Shah Gail L. Rosseau John F. Sarwark |
| author_sort | Priyanka K. Mathur |
| collection | DOAJ |
| description | Background: Spina bifida (SB) is a neural tube defect that affects more than 200,000 pregnancies globally. Folic acid fortification has been shown to be the most effective public health strategy to prevent SB. Patients with SB require surgical and non-surgical orthopaedic care to correct a variety of deformities associated with spina bifida. The benefits of SB prevention compared to its costs — including surgical expenses, healthcare burden, and psychosocial effects — make folic acid fortification necessary. Methods: We conducted a literature review to explore the role of orthopaedic surgery in the care of patients with SB and the role of folic acid fortification in SB prevention. Results: Orthopaedic surgery has a crucial role in spina bifida care with the goal to maximize a patient's functional status. The lifetime economic cost of SB through direct, indirect and educational costs is estimated to be greater than $600,000. Folic acid fortification has been shown to reduce the need for orthopaedic surgeries by decreasing the incidence of neural tube defects. This has been shown to have a high cost benefit ratio for countries. SB prevention leads to better psychosocial, economic and health outcomes for patients. Conclusion: Folic acid fortification has significant economic and health benefits by preventing SB and reducing the number of orthopaedic procedures necessary. We call on governments and healthcare organizations to support the World Health Assembly resolution for folic acid and micronutrient fortification in the prevention of neural tube defects. |
| first_indexed | 2024-03-11T20:48:40Z |
| format | Article |
| id | doaj.art-abcd86915eca4ac28077d3097a720962 |
| institution | Directory Open Access Journal |
| issn | 2773-157X |
| language | English |
| last_indexed | 2024-03-11T20:48:40Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Orthopaedic Reports |
| spelling | doaj.art-abcd86915eca4ac28077d3097a7209622023-10-01T06:03:49ZengElsevierJournal of Orthopaedic Reports2773-157X2023-09-0123100175Beneficial effects of folic acid fortification in the prevention of Spina Bifida and reducing the orthopaedic procedures: A narrative review of the current literaturePriyanka K. Mathur0Pooja Dave1Samuel I. Fuller2Kendrick Cuero3Anthony Chiu4Aribah Shah5Gail L. Rosseau6John F. Sarwark7Northwestern University, Feinberg School of Medicine, 420 E Superior St, Chicago, IL, 60611, USA; Corresponding author. 420 E Superior St, Chicago, IL, 60611, USA.George Washington University, School of Medicine and Health Sciences, 2121 I St NW, Washington, DC, 20052, USAGeorge Washington University, School of Medicine and Health Sciences, 2121 I St NW, Washington, DC, 20052, USAGeorge Washington University, School of Medicine and Health Sciences, 2121 I St NW, Washington, DC, 20052, USAGeorge Washington University, School of Medicine and Health Sciences, 2121 I St NW, Washington, DC, 20052, USAGeorge Washington University, School of Medicine and Health Sciences, 2121 I St NW, Washington, DC, 20052, USADepartment of Neurosurgery, School of Medicine and Health Sciences, George Washington University, Washington, DC, 20052, USA; Barrow Neurological Institute, Phoenix, AZ, USAChildren's Memorial Hospital, Northwestern University Medical School, 225 E Chicago Ave, Chicago, IL, 60611, USABackground: Spina bifida (SB) is a neural tube defect that affects more than 200,000 pregnancies globally. Folic acid fortification has been shown to be the most effective public health strategy to prevent SB. Patients with SB require surgical and non-surgical orthopaedic care to correct a variety of deformities associated with spina bifida. The benefits of SB prevention compared to its costs — including surgical expenses, healthcare burden, and psychosocial effects — make folic acid fortification necessary. Methods: We conducted a literature review to explore the role of orthopaedic surgery in the care of patients with SB and the role of folic acid fortification in SB prevention. Results: Orthopaedic surgery has a crucial role in spina bifida care with the goal to maximize a patient's functional status. The lifetime economic cost of SB through direct, indirect and educational costs is estimated to be greater than $600,000. Folic acid fortification has been shown to reduce the need for orthopaedic surgeries by decreasing the incidence of neural tube defects. This has been shown to have a high cost benefit ratio for countries. SB prevention leads to better psychosocial, economic and health outcomes for patients. Conclusion: Folic acid fortification has significant economic and health benefits by preventing SB and reducing the number of orthopaedic procedures necessary. We call on governments and healthcare organizations to support the World Health Assembly resolution for folic acid and micronutrient fortification in the prevention of neural tube defects.http://www.sciencedirect.com/science/article/pii/S2773157X23000474Spina bifidaWorld health assemblyPreventionFolic acidSpinal dysraphism |
| spellingShingle | Priyanka K. Mathur Pooja Dave Samuel I. Fuller Kendrick Cuero Anthony Chiu Aribah Shah Gail L. Rosseau John F. Sarwark Beneficial effects of folic acid fortification in the prevention of Spina Bifida and reducing the orthopaedic procedures: A narrative review of the current literature Journal of Orthopaedic Reports Spina bifida World health assembly Prevention Folic acid Spinal dysraphism |
| title | Beneficial effects of folic acid fortification in the prevention of Spina Bifida and reducing the orthopaedic procedures: A narrative review of the current literature |
| title_full | Beneficial effects of folic acid fortification in the prevention of Spina Bifida and reducing the orthopaedic procedures: A narrative review of the current literature |
| title_fullStr | Beneficial effects of folic acid fortification in the prevention of Spina Bifida and reducing the orthopaedic procedures: A narrative review of the current literature |
| title_full_unstemmed | Beneficial effects of folic acid fortification in the prevention of Spina Bifida and reducing the orthopaedic procedures: A narrative review of the current literature |
| title_short | Beneficial effects of folic acid fortification in the prevention of Spina Bifida and reducing the orthopaedic procedures: A narrative review of the current literature |
| title_sort | beneficial effects of folic acid fortification in the prevention of spina bifida and reducing the orthopaedic procedures a narrative review of the current literature |
| topic | Spina bifida World health assembly Prevention Folic acid Spinal dysraphism |
| url | http://www.sciencedirect.com/science/article/pii/S2773157X23000474 |
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