Pediatric Liver Transplantation Outcomes for Metabolic and Non-metabolic Diseases in Turkey: A Single Center Experience
Aim:Liver transplantation (LT) is performed for several indications in the pediatric population, including malignancy and acute hepatic failure among others. LT has become an important treatment alternative for metabolic diseases. In most pediatric transplant centers, metabolic liver disease is the...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2019-06-01
|
| Series: | Journal of Pediatric Research |
| Subjects: | |
| Online Access: |
http://jpedres.org/archives/archive-detail/article-preview/pediatric-liver-transplantation-outcomes-for-metab/27901
|
| _version_ | 1797923554733326336 |
|---|---|
| author | Miray Karakoyun Ebru Canda Sirmen Kızılcan Orkan Ergün Murat Kılıç Funda Çetin Sema Aydoğdu |
| author_facet | Miray Karakoyun Ebru Canda Sirmen Kızılcan Orkan Ergün Murat Kılıç Funda Çetin Sema Aydoğdu |
| author_sort | Miray Karakoyun |
| collection | DOAJ |
| description | Aim:Liver transplantation (LT) is performed for several indications in the pediatric population, including malignancy and acute hepatic failure among others. LT has become an important treatment alternative for metabolic diseases. In most pediatric transplant centers, metabolic liver disease is the second most common indication for LT after biliary atresia. Our studies aim is to compare the post-transplant outcomes of those patients with metabolic and other liver diseases in our transplant program.Materials and Methods:One hundred eighty-nine patients who underwent LT between 1997 and 2015 due to metabolic diseases and acute or chronic liver failure were included in the study. This study was performed retrospectively.Results:We enrolled 189 patients in our study. 54% (n=102) male and 46% (n=87) female patients were included in the study. The metabolic disease group included 56 patients and the non-metabolic disease group contained 133 patients. Progressive familial intrahepatic cholestasis is the most common disease among metabolic diseases resulting in LT and Wilson disease is the second most common. Post-transplant immunosuppression was similar for both groups. There was no difference in both groups regarding the onset of post-transplant complications for graft type or recipient age. Biliary and portal vein complications were most particularly defined in the group with non-metabolic diseases. There was no significant difference in survival between the two groups.Conclusion:LT is an important treatment option for acute hepatic failure and end-stage liver diseases. In addition, LT is an alternative treatment option for some metabolic diseases. |
| first_indexed | 2024-04-10T14:48:20Z |
| format | Article |
| id | doaj.art-abce662871784b619bee1007062de56e |
| institution | Directory Open Access Journal |
| issn | 2147-9445 2587-2478 |
| language | English |
| last_indexed | 2024-04-10T14:48:20Z |
| publishDate | 2019-06-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Journal of Pediatric Research |
| spelling | doaj.art-abce662871784b619bee1007062de56e2023-02-15T16:07:43ZengGalenos YayineviJournal of Pediatric Research2147-94452587-24782019-06-016211512010.4274/jpr.galenos.2018.8271313049054Pediatric Liver Transplantation Outcomes for Metabolic and Non-metabolic Diseases in Turkey: A Single Center ExperienceMiray Karakoyun0Ebru Canda1Sirmen Kızılcan2Orkan Ergün3Murat Kılıç4Funda Çetin5Sema Aydoğdu6 Ege University Faculty of Medicine, Department of Pediatric Gastroenterology, Division of Hepatology and Nutrition, İzmir, Turkey Ege University Faculty of Medicine, Department of Inborn Defects of Metabolism, İzmir, Turkey Ege University Faculty of Medicine, Department of Pediatrics, İzmir, Turkey Ege University Faculty of Medicine, Department of Pediatric Surgery, İzmir, Turkey Kent Hospital, Clinic of Transplantation and General Surgery, İzmir, Turkey Ege University Faculty of Medicine, Department of Pediatric Gastroenterology, Division of Hepatology and Nutrition, İzmir, Turkey Ege University Faculty of Medicine, Department of Pediatric Gastroenterology, Division of Hepatology and Nutrition, İzmir, Turkey Aim:Liver transplantation (LT) is performed for several indications in the pediatric population, including malignancy and acute hepatic failure among others. LT has become an important treatment alternative for metabolic diseases. In most pediatric transplant centers, metabolic liver disease is the second most common indication for LT after biliary atresia. Our studies aim is to compare the post-transplant outcomes of those patients with metabolic and other liver diseases in our transplant program.Materials and Methods:One hundred eighty-nine patients who underwent LT between 1997 and 2015 due to metabolic diseases and acute or chronic liver failure were included in the study. This study was performed retrospectively.Results:We enrolled 189 patients in our study. 54% (n=102) male and 46% (n=87) female patients were included in the study. The metabolic disease group included 56 patients and the non-metabolic disease group contained 133 patients. Progressive familial intrahepatic cholestasis is the most common disease among metabolic diseases resulting in LT and Wilson disease is the second most common. Post-transplant immunosuppression was similar for both groups. There was no difference in both groups regarding the onset of post-transplant complications for graft type or recipient age. Biliary and portal vein complications were most particularly defined in the group with non-metabolic diseases. There was no significant difference in survival between the two groups.Conclusion:LT is an important treatment option for acute hepatic failure and end-stage liver diseases. In addition, LT is an alternative treatment option for some metabolic diseases. http://jpedres.org/archives/archive-detail/article-preview/pediatric-liver-transplantation-outcomes-for-metab/27901 Complicationsnon-metabolic diseasesmetabolic diseasesliversurvivaltransplantation |
| spellingShingle | Miray Karakoyun Ebru Canda Sirmen Kızılcan Orkan Ergün Murat Kılıç Funda Çetin Sema Aydoğdu Pediatric Liver Transplantation Outcomes for Metabolic and Non-metabolic Diseases in Turkey: A Single Center Experience Journal of Pediatric Research Complications non-metabolic diseases metabolic diseases liver survival transplantation |
| title | Pediatric Liver Transplantation Outcomes for Metabolic and Non-metabolic Diseases in Turkey: A Single Center Experience |
| title_full | Pediatric Liver Transplantation Outcomes for Metabolic and Non-metabolic Diseases in Turkey: A Single Center Experience |
| title_fullStr | Pediatric Liver Transplantation Outcomes for Metabolic and Non-metabolic Diseases in Turkey: A Single Center Experience |
| title_full_unstemmed | Pediatric Liver Transplantation Outcomes for Metabolic and Non-metabolic Diseases in Turkey: A Single Center Experience |
| title_short | Pediatric Liver Transplantation Outcomes for Metabolic and Non-metabolic Diseases in Turkey: A Single Center Experience |
| title_sort | pediatric liver transplantation outcomes for metabolic and non metabolic diseases in turkey a single center experience |
| topic | Complications non-metabolic diseases metabolic diseases liver survival transplantation |
| url |
http://jpedres.org/archives/archive-detail/article-preview/pediatric-liver-transplantation-outcomes-for-metab/27901
|
| work_keys_str_mv | AT miraykarakoyun pediatriclivertransplantationoutcomesformetabolicandnonmetabolicdiseasesinturkeyasinglecenterexperience AT ebrucanda pediatriclivertransplantationoutcomesformetabolicandnonmetabolicdiseasesinturkeyasinglecenterexperience AT sirmenkızılcan pediatriclivertransplantationoutcomesformetabolicandnonmetabolicdiseasesinturkeyasinglecenterexperience AT orkanergun pediatriclivertransplantationoutcomesformetabolicandnonmetabolicdiseasesinturkeyasinglecenterexperience AT muratkılıc pediatriclivertransplantationoutcomesformetabolicandnonmetabolicdiseasesinturkeyasinglecenterexperience AT fundacetin pediatriclivertransplantationoutcomesformetabolicandnonmetabolicdiseasesinturkeyasinglecenterexperience AT semaaydogdu pediatriclivertransplantationoutcomesformetabolicandnonmetabolicdiseasesinturkeyasinglecenterexperience |