Saturated fatty acids activate ERK signaling to downregulate hepatic sortilin 1 in obese and diabetic mice[S]

Saturated fatty acids activate ERK signaling to downregulate hepatic sortilin 1 in obese and diabetic mice[S]

Hepatic VLDL overproduction is a characteristic feature of diabetes and an important contributor to diabetic dyslipidemia. Hepatic sortilin 1 (Sort1), a cellular trafficking receptor, is a novel regulator of plasma lipid metabolism and reduces plasma cholesterol and triglycerides by inhibiting hepat...

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Bibliographic Details
Main Authors:	Lipeng Bi, John Y.L. Chiang, Wen-Xing Ding, Winston Dunn, Benjamin Roberts, Tiangang Li
Format:	Article
Language:	English
Published:	Elsevier 2013-10-01
Series:	Journal of Lipid Research
Subjects:	extracellular signal-regulated kinase obesity diabetes fatty liver lipid metabolism mitogen-activated protein kinase
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520353013

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