ALDH2 deficiency increases susceptibility to binge alcohol-induced gut leakiness, endotoxemia, and acute liver injury in mice through the gut-liver axis

ALDH2 deficiency increases susceptibility to binge alcohol-induced gut leakiness, endotoxemia, and acute liver injury in mice through the gut-liver axis

Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is the major enzyme responsible for metabolizing toxic acetaldehyde to acetate and acts as a protective or defensive protein against various disease states associated with alcohol use disorder (AUD), including alcohol-related liver disease (ARLD). We hy...

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Bibliographic Details
Main Authors: Wiramon Rungratanawanich, Yuhong Lin, Xin Wang, Toshihiro Kawamoto, Saravana Babu Chidambaram, Byoung-Joon Song
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Redox Biology
Subjects:
Mitochondrial aldehyde dehydrogenase 2 (ALDH2)
Binge alcohol
Gut leakiness
Oxidative and nitrative stress
Endotoxemia
Acute liver injury
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722003494

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