Clinical features and major bleeding predictors for 161 fatal cases of COVID-19: A retrospective observational study
The aim of this study was to investigate the patient characteristics and laboratory parameters for COVID-19 non-survivors as well as to find risk factors for major bleeding complications. For this retrospective study, the data of patients who died with COVID-19 in our intensive care unit were colle...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2022-04-01
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| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/6577 |
| _version_ | 1797261313864368128 |
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| author | Gokhan Alici Hasan Ali Barman Ramazan Asoglu Adem Atici Atike Nazli Akciger Omer Sit Omer Dogan Yucel Yavuz Songul Borahan Omer Genc Baris Gungor |
| author_facet | Gokhan Alici Hasan Ali Barman Ramazan Asoglu Adem Atici Atike Nazli Akciger Omer Sit Omer Dogan Yucel Yavuz Songul Borahan Omer Genc Baris Gungor |
| author_sort | Gokhan Alici |
| collection | DOAJ |
| description |
The aim of this study was to investigate the patient characteristics and laboratory parameters for COVID-19 non-survivors as well as to find risk factors for major bleeding complications. For this retrospective study, the data of patients who died with COVID-19 in our intensive care unit were collected in the period of March 20 - April 30, 2020. D-dimer, platelet count, C-reactive protein (CRP), troponin, and international normalized ratio (INR) levels were recorded on the 1st, 5th, and 10th days of hospitalization in order to investigate the possible correlation of laboratory parameter changes with in-hospital events. A total of 161 non-survivors patients with COVID-19 were included in the study. The median age was 69.8±10.9 years, and 95 (59%) of the population were male. Lung-related complications were the most common in-hospital complications. Patients with COVID-19 had in-hospital complications such as major bleeding (39%), hemoptysis (14%), disseminated intravascular coagulation (13%), liver failure (21%), ARDS (85%), acute kidney injury (40%), and myocardial injury (70%). A multiple logistics regression analysis determined that age, hypertension, diabetes mellitus, use of acetylsalicylic acid (ASA) or low molecular weight heparin (LMWH), hemoglobin, D-dimer, INR, and acute kidney injury were independent predictors of major bleeding. Our results showed that a high proportion of COVID-19 non-survivors suffered from major bleeding complications.
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| first_indexed | 2024-04-24T23:39:14Z |
| format | Article |
| id | doaj.art-abd2463b7913495b957bfda3159ff2f6 |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:39:14Z |
| publishDate | 2022-04-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-abd2463b7913495b957bfda3159ff2f62024-03-15T13:31:07ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2022-04-0122210.17305/bjbms.2021.6577Clinical features and major bleeding predictors for 161 fatal cases of COVID-19: A retrospective observational studyGokhan Alici0https://orcid.org/0000-0002-4589-7566Hasan Ali Barman1Ramazan Asoglu2https://orcid.org/0000-0002-4777-1166Adem Atici3Atike Nazli Akciger4https://orcid.org/0000-0002-2261-1457Omer Sit5Omer Dogan6https://orcid.org/0000-0003-2279-6110Yucel Yavuz7Songul Borahan8Omer Genc9https://orcid.org/0000-0002-9097-5391Baris Gungor10https://orcid.org/0000-0002-8883-117XOkmeydani Training and Research Hospital, Department of Cardiology, Istanbul, TurkeyIstanbul University – Cerrahpaşa, Institute of Cardiology, Department of Cardiology, Istanbul, TurkeyAdiyaman Training ve Research Hospital, Department of Cardiology, Adiyaman, TurkeyIstanbul Medeniyet University, Faculty of Medicine, Goztepe Training and Research Hospital, Department of Cardiology, Istanbul, TurkeyUniversity of Health Sciences, Okmeydani Training and Research Hospital, Department of Cardiology, Istanbul, Turkey University of Health Sciences, Okmeydani Training and Research Hospital, Department of Cardiology, Istanbul, TurkeyIstanbul University – Cerrahpaşa, Institute of Cardiology, Department of Cardiology, Istanbul, TurkeyUniversity of Health Sciences, Okmeydani Training and Research Hospital, Department of Anesthesiology and Intensive Care, Istanbul, TurkeyUniversity of Health Sciences, Okmeydani Training and Research Hospital, Department of Anesthesiology and Intensive Care, Istanbul, TurkeyAgri Training ve Research Hospital, Department of Cardiology, Agri, TurkeyUniversity of Health Sciences, Dr. Siyami Ersek Training and Research Hospital, Department of Cardiology, Istanbul, Turkey The aim of this study was to investigate the patient characteristics and laboratory parameters for COVID-19 non-survivors as well as to find risk factors for major bleeding complications. For this retrospective study, the data of patients who died with COVID-19 in our intensive care unit were collected in the period of March 20 - April 30, 2020. D-dimer, platelet count, C-reactive protein (CRP), troponin, and international normalized ratio (INR) levels were recorded on the 1st, 5th, and 10th days of hospitalization in order to investigate the possible correlation of laboratory parameter changes with in-hospital events. A total of 161 non-survivors patients with COVID-19 were included in the study. The median age was 69.8±10.9 years, and 95 (59%) of the population were male. Lung-related complications were the most common in-hospital complications. Patients with COVID-19 had in-hospital complications such as major bleeding (39%), hemoptysis (14%), disseminated intravascular coagulation (13%), liver failure (21%), ARDS (85%), acute kidney injury (40%), and myocardial injury (70%). A multiple logistics regression analysis determined that age, hypertension, diabetes mellitus, use of acetylsalicylic acid (ASA) or low molecular weight heparin (LMWH), hemoglobin, D-dimer, INR, and acute kidney injury were independent predictors of major bleeding. Our results showed that a high proportion of COVID-19 non-survivors suffered from major bleeding complications. https://www.bjbms.org/ojs/index.php/bjbms/article/view/6577Major bleedingCOVID-19mortalityacute respiratory distress syndromecardiac injury |
| spellingShingle | Gokhan Alici Hasan Ali Barman Ramazan Asoglu Adem Atici Atike Nazli Akciger Omer Sit Omer Dogan Yucel Yavuz Songul Borahan Omer Genc Baris Gungor Clinical features and major bleeding predictors for 161 fatal cases of COVID-19: A retrospective observational study Biomolecules & Biomedicine Major bleeding COVID-19 mortality acute respiratory distress syndrome cardiac injury |
| title | Clinical features and major bleeding predictors for 161 fatal cases of COVID-19: A retrospective observational study |
| title_full | Clinical features and major bleeding predictors for 161 fatal cases of COVID-19: A retrospective observational study |
| title_fullStr | Clinical features and major bleeding predictors for 161 fatal cases of COVID-19: A retrospective observational study |
| title_full_unstemmed | Clinical features and major bleeding predictors for 161 fatal cases of COVID-19: A retrospective observational study |
| title_short | Clinical features and major bleeding predictors for 161 fatal cases of COVID-19: A retrospective observational study |
| title_sort | clinical features and major bleeding predictors for 161 fatal cases of covid 19 a retrospective observational study |
| topic | Major bleeding COVID-19 mortality acute respiratory distress syndrome cardiac injury |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/6577 |
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