A case-control study of human papillomavirus and cervical squamous intraepithelial lesions (SIL) in Harris County, Texas: differences among racial/ethnic groups
We conducted a case-control study of the association between SIL and HPV among whites (W), African Americans (AA), and Hispanics (H) in Harris County, Texas. Cases were identified at M.D. Anderson Cancer Center Colposcopy Clinic. Controls were identified among women obtaining routine Pap screening a...
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| Format: | Article |
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Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz
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| Series: | Cadernos de Saúde Pública |
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| Online Access: | http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0102-311X1998000700015&lng=en&tlng=en |
| _version_ | 1818506225151639552 |
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| author | Guillermo Tortolero-Luna Michele Follen Mitchell David C. Swan Ruth Ann Tucker Louise Wideroff Joseph P. Icenogle |
| author_facet | Guillermo Tortolero-Luna Michele Follen Mitchell David C. Swan Ruth Ann Tucker Louise Wideroff Joseph P. Icenogle |
| author_sort | Guillermo Tortolero-Luna |
| collection | DOAJ |
| description | We conducted a case-control study of the association between SIL and HPV among whites (W), African Americans (AA), and Hispanics (H) in Harris County, Texas. Cases were identified at M.D. Anderson Cancer Center Colposcopy Clinic. Controls were identified among women obtaining routine Pap screening at two Harris County Health Department Clinics. HPV was detected by a PCR-based fluorescent assay. Dichotomous and polytomous logistic regression models were used to estimate adjusted odd ratios (AOR) and 95% confidence intervals (CI) for SIL among racial/ethnic groups and grade of disease. Prevalence of HPV infection was 64% in low grade SIL (LSIL), 84% in high grade SIL (HSIL), and 19% in controls. Risk of SIL was higher in H than in W and AA, AOR 29.5 (12.4-70.5), 15.3 (6.0-33.8), and 5.8 (2.6-12.6), respectively. Similarly, racial/ethnic differences were observed for both LSIL (AOR = 16.6, 7.7, and 4.3, respectively) and HSIL (AOR = 78.6, 34.6, and 14.2, respectively). Findings support the association between SIL and HPV and differences in the strength of the association with LSILs and HSILs. Data also suggest a higher risk for H and a lower risk for AA. |
| first_indexed | 2024-12-10T22:01:42Z |
| format | Article |
| id | doaj.art-abd2b9c14df24045ae659c115a1a39f5 |
| institution | Directory Open Access Journal |
| issn | 0102-311X 1678-4464 |
| language | English |
| last_indexed | 2024-12-10T22:01:42Z |
| publisher | Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz |
| record_format | Article |
| series | Cadernos de Saúde Pública |
| spelling | doaj.art-abd2b9c14df24045ae659c115a1a39f52022-12-22T01:31:53ZengEscola Nacional de Saúde Pública, Fundação Oswaldo CruzCadernos de Saúde Pública0102-311X1678-446414suppl 3S149S159S0102-311X1998000700015A case-control study of human papillomavirus and cervical squamous intraepithelial lesions (SIL) in Harris County, Texas: differences among racial/ethnic groupsGuillermo Tortolero-Luna0Michele Follen Mitchell1David C. Swan2Ruth Ann Tucker3Louise Wideroff4Joseph P. Icenogle5University of TexasUniversity of TexasNational Center for Infectious DiseasesNational Center for Infectious DiseasesNational Cancer InstituteNational Center for Infectious DiseasesWe conducted a case-control study of the association between SIL and HPV among whites (W), African Americans (AA), and Hispanics (H) in Harris County, Texas. Cases were identified at M.D. Anderson Cancer Center Colposcopy Clinic. Controls were identified among women obtaining routine Pap screening at two Harris County Health Department Clinics. HPV was detected by a PCR-based fluorescent assay. Dichotomous and polytomous logistic regression models were used to estimate adjusted odd ratios (AOR) and 95% confidence intervals (CI) for SIL among racial/ethnic groups and grade of disease. Prevalence of HPV infection was 64% in low grade SIL (LSIL), 84% in high grade SIL (HSIL), and 19% in controls. Risk of SIL was higher in H than in W and AA, AOR 29.5 (12.4-70.5), 15.3 (6.0-33.8), and 5.8 (2.6-12.6), respectively. Similarly, racial/ethnic differences were observed for both LSIL (AOR = 16.6, 7.7, and 4.3, respectively) and HSIL (AOR = 78.6, 34.6, and 14.2, respectively). Findings support the association between SIL and HPV and differences in the strength of the association with LSILs and HSILs. Data also suggest a higher risk for H and a lower risk for AA.http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0102-311X1998000700015&lng=en&tlng=enpapillomaviruscervix neoplasmsethnic groupscase-control studies |
| spellingShingle | Guillermo Tortolero-Luna Michele Follen Mitchell David C. Swan Ruth Ann Tucker Louise Wideroff Joseph P. Icenogle A case-control study of human papillomavirus and cervical squamous intraepithelial lesions (SIL) in Harris County, Texas: differences among racial/ethnic groups Cadernos de Saúde Pública papillomavirus cervix neoplasms ethnic groups case-control studies |
| title | A case-control study of human papillomavirus and cervical squamous intraepithelial lesions (SIL) in Harris County, Texas: differences among racial/ethnic groups |
| title_full | A case-control study of human papillomavirus and cervical squamous intraepithelial lesions (SIL) in Harris County, Texas: differences among racial/ethnic groups |
| title_fullStr | A case-control study of human papillomavirus and cervical squamous intraepithelial lesions (SIL) in Harris County, Texas: differences among racial/ethnic groups |
| title_full_unstemmed | A case-control study of human papillomavirus and cervical squamous intraepithelial lesions (SIL) in Harris County, Texas: differences among racial/ethnic groups |
| title_short | A case-control study of human papillomavirus and cervical squamous intraepithelial lesions (SIL) in Harris County, Texas: differences among racial/ethnic groups |
| title_sort | case control study of human papillomavirus and cervical squamous intraepithelial lesions sil in harris county texas differences among racial ethnic groups |
| topic | papillomavirus cervix neoplasms ethnic groups case-control studies |
| url | http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0102-311X1998000700015&lng=en&tlng=en |
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