Marine Bioactive Compounds against <i>Aspergillus fumigatus</i>: Challenges and Future Prospects
With the mortality rate of invasive aspergillosis caused by <i>Aspergillus fumigatus</i> reaching almost 100% among some groups of patients, and with the rapidly increasing resistance of <i>A. fumigatus</i> to available antifungal drugs, new antifungal agents have never been...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/9/11/813 |
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| author | Chukwuemeka Samson Ahamefule Blessing C. Ezeuduji James C. Ogbonna Anene N. Moneke Anthony C. Ike Bin Wang Cheng Jin Wenxia Fang |
| author_facet | Chukwuemeka Samson Ahamefule Blessing C. Ezeuduji James C. Ogbonna Anene N. Moneke Anthony C. Ike Bin Wang Cheng Jin Wenxia Fang |
| author_sort | Chukwuemeka Samson Ahamefule |
| collection | DOAJ |
| description | With the mortality rate of invasive aspergillosis caused by <i>Aspergillus fumigatus</i> reaching almost 100% among some groups of patients, and with the rapidly increasing resistance of <i>A. fumigatus</i> to available antifungal drugs, new antifungal agents have never been more desirable than now. Numerous bioactive compounds were isolated and characterized from marine resources. However, only a few exhibited a potent activity against <i>A. fumigatus</i> when compared to the multitude that did against some other pathogens. Here, we review the marine bioactive compounds that display a bioactivity against <i>A. fumigatus.</i> The challenges hampering the discovery of antifungal agents from this rich habitat are also critically analyzed. Further, we propose strategies that could speed up an efficient discovery and broaden the dimensions of screening in order to obtain promising <i>in vivo</i> antifungal agents with new modes of action. |
| first_indexed | 2024-03-10T14:50:01Z |
| format | Article |
| id | doaj.art-abd31bd7485c46559bb8303adaf6a573 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T14:50:01Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-abd31bd7485c46559bb8303adaf6a5732023-11-20T21:04:20ZengMDPI AGAntibiotics2079-63822020-11-0191181310.3390/antibiotics9110813Marine Bioactive Compounds against <i>Aspergillus fumigatus</i>: Challenges and Future ProspectsChukwuemeka Samson Ahamefule0Blessing C. Ezeuduji1James C. Ogbonna2Anene N. Moneke3Anthony C. Ike4Bin Wang5Cheng Jin6Wenxia Fang7National Engineering Research Center for Non-Food Biorefinery, Guangxi Academy of Sciences, Nanning 530007, Guangxi, ChinaDepartment of Microbiology, University of Jos, Jos 930001, NigeriaDepartment of Microbiology, University of Nigeria, Nsukka 410001, Enugu State, NigeriaDepartment of Microbiology, University of Nigeria, Nsukka 410001, Enugu State, NigeriaDepartment of Microbiology, University of Nigeria, Nsukka 410001, Enugu State, NigeriaNational Engineering Research Center for Non-Food Biorefinery, Guangxi Academy of Sciences, Nanning 530007, Guangxi, ChinaNational Engineering Research Center for Non-Food Biorefinery, Guangxi Academy of Sciences, Nanning 530007, Guangxi, ChinaNational Engineering Research Center for Non-Food Biorefinery, Guangxi Academy of Sciences, Nanning 530007, Guangxi, ChinaWith the mortality rate of invasive aspergillosis caused by <i>Aspergillus fumigatus</i> reaching almost 100% among some groups of patients, and with the rapidly increasing resistance of <i>A. fumigatus</i> to available antifungal drugs, new antifungal agents have never been more desirable than now. Numerous bioactive compounds were isolated and characterized from marine resources. However, only a few exhibited a potent activity against <i>A. fumigatus</i> when compared to the multitude that did against some other pathogens. Here, we review the marine bioactive compounds that display a bioactivity against <i>A. fumigatus.</i> The challenges hampering the discovery of antifungal agents from this rich habitat are also critically analyzed. Further, we propose strategies that could speed up an efficient discovery and broaden the dimensions of screening in order to obtain promising <i>in vivo</i> antifungal agents with new modes of action.https://www.mdpi.com/2079-6382/9/11/813marine resources<i>Aspergillus fumigatus</i>bioactive compoundsscreening modelfungi |
| spellingShingle | Chukwuemeka Samson Ahamefule Blessing C. Ezeuduji James C. Ogbonna Anene N. Moneke Anthony C. Ike Bin Wang Cheng Jin Wenxia Fang Marine Bioactive Compounds against <i>Aspergillus fumigatus</i>: Challenges and Future Prospects Antibiotics marine resources <i>Aspergillus fumigatus</i> bioactive compounds screening model fungi |
| title | Marine Bioactive Compounds against <i>Aspergillus fumigatus</i>: Challenges and Future Prospects |
| title_full | Marine Bioactive Compounds against <i>Aspergillus fumigatus</i>: Challenges and Future Prospects |
| title_fullStr | Marine Bioactive Compounds against <i>Aspergillus fumigatus</i>: Challenges and Future Prospects |
| title_full_unstemmed | Marine Bioactive Compounds against <i>Aspergillus fumigatus</i>: Challenges and Future Prospects |
| title_short | Marine Bioactive Compounds against <i>Aspergillus fumigatus</i>: Challenges and Future Prospects |
| title_sort | marine bioactive compounds against i aspergillus fumigatus i challenges and future prospects |
| topic | marine resources <i>Aspergillus fumigatus</i> bioactive compounds screening model fungi |
| url | https://www.mdpi.com/2079-6382/9/11/813 |
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