The Prospect of Serum Magnesium and an Electrolyte Panel as an Adjuvant Cardiac Biomarker in the Management of Acute Myocardial Infarction
Background: Ischemic heart disease accounts 12.2% deaths worldwide. Serum magnesium (Mg+) status is often ignored in Acute Myocardial Infarction (AMI). Studies showed alterations in the levels of serum electrolytes including magnesium in AMI. Aim: To evaluate serum Mg+ and other electrolytes as...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2013-05-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/2947/8-%205524_E(C)_PF1(M)_F(P)_PF1(PP)_PFA(P)_OLF_PF1(PP)_PF2(PP).pdf |
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| author | Ramesh Ramasamy Sathish Babu Murugaiyan Niranjan Gopal Rachel Shalini |
| author_facet | Ramesh Ramasamy Sathish Babu Murugaiyan Niranjan Gopal Rachel Shalini |
| author_sort | Ramesh Ramasamy |
| collection | DOAJ |
| description | Background: Ischemic heart disease accounts 12.2% deaths
worldwide. Serum magnesium (Mg+) status is often ignored
in Acute Myocardial Infarction (AMI). Studies showed alterations in the levels of serum electrolytes including magnesium
in AMI.
Aim: To evaluate serum Mg+ and other electrolytes as adjuvant markers in the diagnosis of AMI.
Design and Settings: Case control study was conducted in
South Indian male population with AMI within six hours of onset of symptoms.
Patients and Methods: Study includes sixty patients with AMI
and 100 controls. Serum electrolytes were estimated using
electrolyte analyzer. Data were compared by using student‘t’
test. ROC was drawn to find out optimum cutoff for diagnosing AMI. Pearson’s correlation was done to see the association
among the markers.
Results: Serum Ca, Mg, K and Na electrolytes were significantly lower (‘p’<0.001) in AMI. Ca:Mg, K:Mg, and Na:K ratios were
significantly higher when compared to controls (‘p’<0.001).
There was significant correlation of serum Mg levels with other
cardiac markers (Total CK, CK–Mb, Troponin –T) of AMI (‘p’
<0.05).ROC analysis of Na:Mg (40.9), Ca:Mg (3.43) and K:Mg
(2.74) ratios showed optimum cutoffs in diagnosis of AMI.
Conclusion: Serum Mg, Ca:mg, K:mg and Na:K ratios could
be useful adjuvant markers in diagnosis of AMI. |
| first_indexed | 2024-12-12T04:55:39Z |
| format | Article |
| id | doaj.art-abd32ac4f75c49229a3e4c47580b6b72 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-12T04:55:39Z |
| publishDate | 2013-05-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-abd32ac4f75c49229a3e4c47580b6b722022-12-22T00:37:22ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2013-05-017581782010.7860/JCDR/2013/5524.2947The Prospect of Serum Magnesium and an Electrolyte Panel as an Adjuvant Cardiac Biomarker in the Management of Acute Myocardial InfarctionRamesh Ramasamy0Sathish Babu Murugaiyan1Niranjan Gopal2Rachel Shalini3Professor & Head, Department of Biochemistry, Mahathma Gandhi Medical College and Research Institute Pillayarkuppam Puducherry - 605 402, India.Assistant Professor, Department of Biochemistry, Mahathma Gandhi Medical College And Research Institute, Pillayarkuppam, Puducherry - 605 402, India. Assistant Professor, Department of Biochemistry, Mahathma Gandhi Medical College And Research Institute, Pillayarkuppam, Puducherry - 605 402, India. First year MD Student, Department of Biochemistry, Mahathma Gandhi Medical College And Research Institute, Pillayarkuppam, Puducherry - 605 402, India. Background: Ischemic heart disease accounts 12.2% deaths worldwide. Serum magnesium (Mg+) status is often ignored in Acute Myocardial Infarction (AMI). Studies showed alterations in the levels of serum electrolytes including magnesium in AMI. Aim: To evaluate serum Mg+ and other electrolytes as adjuvant markers in the diagnosis of AMI. Design and Settings: Case control study was conducted in South Indian male population with AMI within six hours of onset of symptoms. Patients and Methods: Study includes sixty patients with AMI and 100 controls. Serum electrolytes were estimated using electrolyte analyzer. Data were compared by using student‘t’ test. ROC was drawn to find out optimum cutoff for diagnosing AMI. Pearson’s correlation was done to see the association among the markers. Results: Serum Ca, Mg, K and Na electrolytes were significantly lower (‘p’<0.001) in AMI. Ca:Mg, K:Mg, and Na:K ratios were significantly higher when compared to controls (‘p’<0.001). There was significant correlation of serum Mg levels with other cardiac markers (Total CK, CK–Mb, Troponin –T) of AMI (‘p’ <0.05).ROC analysis of Na:Mg (40.9), Ca:Mg (3.43) and K:Mg (2.74) ratios showed optimum cutoffs in diagnosis of AMI. Conclusion: Serum Mg, Ca:mg, K:mg and Na:K ratios could be useful adjuvant markers in diagnosis of AMI.https://jcdr.net/articles/PDF/2947/8-%205524_E(C)_PF1(M)_F(P)_PF1(PP)_PFA(P)_OLF_PF1(PP)_PF2(PP).pdfacute myocardial infarctionmagnesiumelectrolytesdiagnostic markeroptimum cut off |
| spellingShingle | Ramesh Ramasamy Sathish Babu Murugaiyan Niranjan Gopal Rachel Shalini The Prospect of Serum Magnesium and an Electrolyte Panel as an Adjuvant Cardiac Biomarker in the Management of Acute Myocardial Infarction Journal of Clinical and Diagnostic Research acute myocardial infarction magnesium electrolytes diagnostic marker optimum cut off |
| title | The Prospect of Serum Magnesium and an Electrolyte Panel as an Adjuvant Cardiac Biomarker in the Management of Acute Myocardial Infarction |
| title_full | The Prospect of Serum Magnesium and an Electrolyte Panel as an Adjuvant Cardiac Biomarker in the Management of Acute Myocardial Infarction |
| title_fullStr | The Prospect of Serum Magnesium and an Electrolyte Panel as an Adjuvant Cardiac Biomarker in the Management of Acute Myocardial Infarction |
| title_full_unstemmed | The Prospect of Serum Magnesium and an Electrolyte Panel as an Adjuvant Cardiac Biomarker in the Management of Acute Myocardial Infarction |
| title_short | The Prospect of Serum Magnesium and an Electrolyte Panel as an Adjuvant Cardiac Biomarker in the Management of Acute Myocardial Infarction |
| title_sort | prospect of serum magnesium and an electrolyte panel as an adjuvant cardiac biomarker in the management of acute myocardial infarction |
| topic | acute myocardial infarction magnesium electrolytes diagnostic marker optimum cut off |
| url | https://jcdr.net/articles/PDF/2947/8-%205524_E(C)_PF1(M)_F(P)_PF1(PP)_PFA(P)_OLF_PF1(PP)_PF2(PP).pdf |
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