Association of peripheral immunity with cognition, neuroimaging, and Alzheimer’s pathology
Abstract Background Neuroinflammation has been considered to be a driving force of Alzheimer’s disease. However, the association between peripheral immunity and AD has been rarely investigated. Methods Separate regression analyses were conducted to explore the associations among peripheral immune ma...
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| Format: | Article |
| Language: | English |
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BMC
2022-02-01
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| Series: | Alzheimer’s Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13195-022-00968-y |
| _version_ | 1818330420181204992 |
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| author | Jia-Hui Hou Ya-Nan Ou Wei Xu Peng-Fei Zhang Lan Tan Jin-Tai Yu on behalf of Alzheimer’s Disease Neuroimaging Initiative |
| author_facet | Jia-Hui Hou Ya-Nan Ou Wei Xu Peng-Fei Zhang Lan Tan Jin-Tai Yu on behalf of Alzheimer’s Disease Neuroimaging Initiative |
| author_sort | Jia-Hui Hou |
| collection | DOAJ |
| description | Abstract Background Neuroinflammation has been considered to be a driving force of Alzheimer’s disease. However, the association between peripheral immunity and AD has been rarely investigated. Methods Separate regression analyses were conducted to explore the associations among peripheral immune markers and cognition, neuroimaging, and AD pathology. Causal mediation analyses were used to investigate whether the associations with cognition were mediated by AD pathology. Results A total of 1107 participants (43.9% female, mean age of 73.2 years) from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) were included. Regression analyses indicated that elevated neutrophils (NEU) count and neutrophil-lymphocyte ratio (NLR) were associated with lower levels of global cognition, memory function (MEM), and executive function (EF), and reduced brain metabolism by 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) as well as greater ventricular volume. An elevated NLR was associated with a lower level of β-amyloid (Aβ) and a higher level of total tau (T-tau) in cerebrospinal fluid (CSF), smaller hippocampal volume (HV), and lesser entorhinal cortex (EC) thickness. On the contrary, an elevated level of lymphocytes (LYM) was associated with a higher level of Aβ and a lower level of T-tau in CSF, better cognition, and less atrophy of brain regions (ventricular volume, HV, and EC thickness). The associations of LYM and NLR with cognition were mediated by Aβ and T-tau pathology (proportion: 18%~64%; p < 0.05). Conclusions We revealed that two types of peripheral immune cells (NEU and LYM) and the ratio of these two cell types (NLR) had associations with cognition, neuroimaging, and AD pathology. The associations might be mediated by Aβ and tau pathology. |
| first_indexed | 2024-12-13T13:03:40Z |
| format | Article |
| id | doaj.art-abd3c2e73f024550983b8b1894276f1b |
| institution | Directory Open Access Journal |
| issn | 1758-9193 |
| language | English |
| last_indexed | 2024-12-13T13:03:40Z |
| publishDate | 2022-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Alzheimer’s Research & Therapy |
| spelling | doaj.art-abd3c2e73f024550983b8b1894276f1b2022-12-21T23:44:54ZengBMCAlzheimer’s Research & Therapy1758-91932022-02-0114111110.1186/s13195-022-00968-yAssociation of peripheral immunity with cognition, neuroimaging, and Alzheimer’s pathologyJia-Hui Hou0Ya-Nan Ou1Wei Xu2Peng-Fei Zhang3Lan Tan4Jin-Tai Yu5on behalf of Alzheimer’s Disease Neuroimaging InitiativeDepartment of Neurology, Qingdao Municipal Hospital, Qingdao UniversityDepartment of Neurology, Qingdao Municipal Hospital, Qingdao UniversityDepartment of Neurology, Qingdao Municipal Hospital, Qingdao UniversityDepartment of Neurology, Qingdao Municipal Hospital, Qingdao UniversityDepartment of Neurology, Qingdao Municipal Hospital, Qingdao UniversityDepartment of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan UniversityAbstract Background Neuroinflammation has been considered to be a driving force of Alzheimer’s disease. However, the association between peripheral immunity and AD has been rarely investigated. Methods Separate regression analyses were conducted to explore the associations among peripheral immune markers and cognition, neuroimaging, and AD pathology. Causal mediation analyses were used to investigate whether the associations with cognition were mediated by AD pathology. Results A total of 1107 participants (43.9% female, mean age of 73.2 years) from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) were included. Regression analyses indicated that elevated neutrophils (NEU) count and neutrophil-lymphocyte ratio (NLR) were associated with lower levels of global cognition, memory function (MEM), and executive function (EF), and reduced brain metabolism by 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) as well as greater ventricular volume. An elevated NLR was associated with a lower level of β-amyloid (Aβ) and a higher level of total tau (T-tau) in cerebrospinal fluid (CSF), smaller hippocampal volume (HV), and lesser entorhinal cortex (EC) thickness. On the contrary, an elevated level of lymphocytes (LYM) was associated with a higher level of Aβ and a lower level of T-tau in CSF, better cognition, and less atrophy of brain regions (ventricular volume, HV, and EC thickness). The associations of LYM and NLR with cognition were mediated by Aβ and T-tau pathology (proportion: 18%~64%; p < 0.05). Conclusions We revealed that two types of peripheral immune cells (NEU and LYM) and the ratio of these two cell types (NLR) had associations with cognition, neuroimaging, and AD pathology. The associations might be mediated by Aβ and tau pathology.https://doi.org/10.1186/s13195-022-00968-yPeripheral immunityAlzheimer’s diseaseNeutrophil-lymphocyte ratioNeutrophilLymphocyteMediation |
| spellingShingle | Jia-Hui Hou Ya-Nan Ou Wei Xu Peng-Fei Zhang Lan Tan Jin-Tai Yu on behalf of Alzheimer’s Disease Neuroimaging Initiative Association of peripheral immunity with cognition, neuroimaging, and Alzheimer’s pathology Alzheimer’s Research & Therapy Peripheral immunity Alzheimer’s disease Neutrophil-lymphocyte ratio Neutrophil Lymphocyte Mediation |
| title | Association of peripheral immunity with cognition, neuroimaging, and Alzheimer’s pathology |
| title_full | Association of peripheral immunity with cognition, neuroimaging, and Alzheimer’s pathology |
| title_fullStr | Association of peripheral immunity with cognition, neuroimaging, and Alzheimer’s pathology |
| title_full_unstemmed | Association of peripheral immunity with cognition, neuroimaging, and Alzheimer’s pathology |
| title_short | Association of peripheral immunity with cognition, neuroimaging, and Alzheimer’s pathology |
| title_sort | association of peripheral immunity with cognition neuroimaging and alzheimer s pathology |
| topic | Peripheral immunity Alzheimer’s disease Neutrophil-lymphocyte ratio Neutrophil Lymphocyte Mediation |
| url | https://doi.org/10.1186/s13195-022-00968-y |
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