Blocking of efflux transporters in rats improves translational validation of brain radioligands

Blocking of efflux transporters in rats improves translational validation of brain radioligands

Abstract Background Positron emission tomography (PET) is a molecular imaging technique that can be used to investigate the in vivo pharmacology of drugs. Initial preclinical evaluation of PET tracers is often conducted in rodents due to the accessibility of disease models as well as economic consid...

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Bibliographic Details
Main Authors: Vladimir Shalgunov, Mengfei Xiong, Elina T. L’Estrade, Nakul R. Raval, Ida V. Andersen, Fraser G. Edgar, Nikolaj R. Speth, Simone L. Baerentzen, Hanne D. Hansen, Lene L. Donovan, Arafat Nasser, Siv T. Peitersen, Andreas Kjaer, Gitte M. Knudsen, Stina Syvänen, Mikael Palner, Matthias M. Herth
Format: Article
Language:English
Published: SpringerOpen 2020-10-01
Series:EJNMMI Research
Subjects:
P-gp
Efflux transporter
PET
Rodents
Pigs
Rats
Online Access:http://link.springer.com/article/10.1186/s13550-020-00718-x

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