The association between serum high-sensitivity cardiac troponin T and acute myocardial infarction in patients with suspected chronic coronary syndrome is modified by body mass index
Background: Higher systemic concentrations of cardiac troponins and biomarkers of inflammation and endothelial dysfunction as well as obesity are associated with increased risk of cardiovascular disease (CVD) and may share pathophysiological pathways. We sought to explore the association between ser...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-12-01
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| Series: | International Journal of Cardiology. Cardiovascular Risk and Prevention |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772487521000118 |
| _version_ | 1798016133422383104 |
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| author | Vegard Vavik Kristin Moberg Aakre Eva Kristine Ringdal Pedersen Gard Frodahl Tveitevåg Svingen Grethe Seppola Tell Ottar Nygård Kjell Vikenes |
| author_facet | Vegard Vavik Kristin Moberg Aakre Eva Kristine Ringdal Pedersen Gard Frodahl Tveitevåg Svingen Grethe Seppola Tell Ottar Nygård Kjell Vikenes |
| author_sort | Vegard Vavik |
| collection | DOAJ |
| description | Background: Higher systemic concentrations of cardiac troponins and biomarkers of inflammation and endothelial dysfunction as well as obesity are associated with increased risk of cardiovascular disease (CVD) and may share pathophysiological pathways. We sought to explore the association between serum high sensitive cardiac troponin T (hs-cTnT) and future acute myocardial infarction (AMI) according to body mass index (BMI) among patients with suspected chronic coronary syndrome (CCS), as well as interactions with C-reactive protein (CRP) and asymmetric dimethylarginine (ADMA). Methods: A total of 3879 patients with baseline hs-cTnT ≤ 30 ng/L who underwent elective coronary angiography due to chronic coronary syndrome (CCS) were followed to subsequent AMI or end of 2009. Risk associations between hs-cTnT and incident AMI were explored with Cox regression according to BMI categories <25 kg/m 2, 25–30kg/m2 and >30kg/m2 and quartiles of serum CRP and plasma ADMA. Results: Median (25 th −75 th percentile) age was 62 (54–69) years and 2773 (77.5%) were men. During median 7.5 (25 th −75 th percentile) (6.9–9.2) years of follow-up, 460 (11.9%) patients experienced an AMI. The risk relationship between hs-cTnT and incident AMI was stronger among patients in the higher vs lower BMI categories, HR 1.087 (1.055–1.119), P for interaction 0.043. A similar interaction was not found in categories of CRP or ADMA. Conclusion: The risk relationship of hs-cTnT with incident AMI was stronger in patients with higher BMI. Our results motivate further studies into potential pathophysiological mechanisms connecting hs-cTnT with increased cardiovascular risk. |
| first_indexed | 2024-04-11T15:45:00Z |
| format | Article |
| id | doaj.art-abd54aa233b0494c9abf0d93072cb196 |
| institution | Directory Open Access Journal |
| issn | 2772-4875 |
| language | English |
| last_indexed | 2024-04-11T15:45:00Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology. Cardiovascular Risk and Prevention |
| spelling | doaj.art-abd54aa233b0494c9abf0d93072cb1962022-12-22T04:15:36ZengElsevierInternational Journal of Cardiology. Cardiovascular Risk and Prevention2772-48752021-12-0111200109The association between serum high-sensitivity cardiac troponin T and acute myocardial infarction in patients with suspected chronic coronary syndrome is modified by body mass indexVegard Vavik0Kristin Moberg Aakre1Eva Kristine Ringdal Pedersen2Gard Frodahl Tveitevåg Svingen3Grethe Seppola Tell4Ottar Nygård5Kjell Vikenes6Department of Heart Disease, Haukeland University Hospital, Bergen, Norway; Corresponding author. Haukeland University Hospital, Department of Heart Disease, Postbox 1400, 5021, Bergen, Norway.Department of Heart Disease, Haukeland University Hospital, Bergen, Norway; Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, NorwayDepartment of Heart Disease, Haukeland University Hospital, Bergen, NorwayDepartment of Heart Disease, Haukeland University Hospital, Bergen, NorwayDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, NorwayDepartment of Heart Disease, Haukeland University Hospital, Bergen, Norway; Department of Clinical Science, University of Bergen, Bergen, NorwayDepartment of Heart Disease, Haukeland University Hospital, Bergen, Norway; Department of Clinical Science, University of Bergen, Bergen, NorwayBackground: Higher systemic concentrations of cardiac troponins and biomarkers of inflammation and endothelial dysfunction as well as obesity are associated with increased risk of cardiovascular disease (CVD) and may share pathophysiological pathways. We sought to explore the association between serum high sensitive cardiac troponin T (hs-cTnT) and future acute myocardial infarction (AMI) according to body mass index (BMI) among patients with suspected chronic coronary syndrome (CCS), as well as interactions with C-reactive protein (CRP) and asymmetric dimethylarginine (ADMA). Methods: A total of 3879 patients with baseline hs-cTnT ≤ 30 ng/L who underwent elective coronary angiography due to chronic coronary syndrome (CCS) were followed to subsequent AMI or end of 2009. Risk associations between hs-cTnT and incident AMI were explored with Cox regression according to BMI categories <25 kg/m 2, 25–30kg/m2 and >30kg/m2 and quartiles of serum CRP and plasma ADMA. Results: Median (25 th −75 th percentile) age was 62 (54–69) years and 2773 (77.5%) were men. During median 7.5 (25 th −75 th percentile) (6.9–9.2) years of follow-up, 460 (11.9%) patients experienced an AMI. The risk relationship between hs-cTnT and incident AMI was stronger among patients in the higher vs lower BMI categories, HR 1.087 (1.055–1.119), P for interaction 0.043. A similar interaction was not found in categories of CRP or ADMA. Conclusion: The risk relationship of hs-cTnT with incident AMI was stronger in patients with higher BMI. Our results motivate further studies into potential pathophysiological mechanisms connecting hs-cTnT with increased cardiovascular risk.http://www.sciencedirect.com/science/article/pii/S2772487521000118Cardiac troponin TBody mass indexInflammationAcute myocardial infarction |
| spellingShingle | Vegard Vavik Kristin Moberg Aakre Eva Kristine Ringdal Pedersen Gard Frodahl Tveitevåg Svingen Grethe Seppola Tell Ottar Nygård Kjell Vikenes The association between serum high-sensitivity cardiac troponin T and acute myocardial infarction in patients with suspected chronic coronary syndrome is modified by body mass index International Journal of Cardiology. Cardiovascular Risk and Prevention Cardiac troponin T Body mass index Inflammation Acute myocardial infarction |
| title | The association between serum high-sensitivity cardiac troponin T and acute myocardial infarction in patients with suspected chronic coronary syndrome is modified by body mass index |
| title_full | The association between serum high-sensitivity cardiac troponin T and acute myocardial infarction in patients with suspected chronic coronary syndrome is modified by body mass index |
| title_fullStr | The association between serum high-sensitivity cardiac troponin T and acute myocardial infarction in patients with suspected chronic coronary syndrome is modified by body mass index |
| title_full_unstemmed | The association between serum high-sensitivity cardiac troponin T and acute myocardial infarction in patients with suspected chronic coronary syndrome is modified by body mass index |
| title_short | The association between serum high-sensitivity cardiac troponin T and acute myocardial infarction in patients with suspected chronic coronary syndrome is modified by body mass index |
| title_sort | association between serum high sensitivity cardiac troponin t and acute myocardial infarction in patients with suspected chronic coronary syndrome is modified by body mass index |
| topic | Cardiac troponin T Body mass index Inflammation Acute myocardial infarction |
| url | http://www.sciencedirect.com/science/article/pii/S2772487521000118 |
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