Serum High-Sensitivity C-Reactive Protein Is Associated with Postoperative Psychiatric Status in Patients with Empty Nose Syndrome
Many patients diagnosed with empty nose syndrome (ENS) later develop mental illness. The literature addressing biomarkers associated with postoperative psychiatric status is limited. This study aimed to assess the association between high-sensitivity C-reactive protein (hs-CRP) and psychiatric statu...
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| Format: | Article |
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MDPI AG
2021-12-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/12/2388 |
| _version_ | 1797505409462829056 |
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| author | Chia-Hsiang Fu Hung-Chin Chen Chi-Che Huang Po-Hung Chang Ta-Jen Lee |
| author_facet | Chia-Hsiang Fu Hung-Chin Chen Chi-Che Huang Po-Hung Chang Ta-Jen Lee |
| author_sort | Chia-Hsiang Fu |
| collection | DOAJ |
| description | Many patients diagnosed with empty nose syndrome (ENS) later develop mental illness. The literature addressing biomarkers associated with postoperative psychiatric status is limited. This study aimed to assess the association between high-sensitivity C-reactive protein (hs-CRP) and psychiatric status after surgery in ENS. We recruited patients with ENS undergoing endonasal submucosal implantation. Their pre- and postoperative psychiatric status was evaluated using the Beck depression inventory-II (BDI-II) and the Beck Anxiety Inventory (BAI). Serum hs-CRP was analyzed one day before and one year after surgery. Of the 43 patients enrolled, all subjective measurements had improved (symptom scores decreased) significantly by the third month postoperatively and remained plateaued till 12 months. Those with preoperative hs-CRP levels > 2.02 mg/L were likely to remain depressive 1 year postoperatively. The regression model showed that a preoperative hs-CRP level > 2.02 mg/L was significantly correlated with postoperative depression in patients with ENS (odds ratio, 19.9). Hs-CRP level seems to be a feasible predictor of surgical outcome regarding improved depression in patients with ENS. Patients with higher preoperative hs-CRP levels should be monitored closely after surgery. |
| first_indexed | 2024-03-10T04:18:14Z |
| format | Article |
| id | doaj.art-abd58e582a22481997d3e316bdf639eb |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T04:18:14Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-abd58e582a22481997d3e316bdf639eb2023-11-23T07:55:25ZengMDPI AGDiagnostics2075-44182021-12-011112238810.3390/diagnostics11122388Serum High-Sensitivity C-Reactive Protein Is Associated with Postoperative Psychiatric Status in Patients with Empty Nose SyndromeChia-Hsiang Fu0Hung-Chin Chen1Chi-Che Huang2Po-Hung Chang3Ta-Jen Lee4Department of Otolaryngology—Head and Neck Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan 333604, TaiwanDepartment of Otolaryngology—Head and Neck Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan 333604, TaiwanDepartment of Otolaryngology—Head and Neck Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan 333604, TaiwanDepartment of Otolaryngology—Head and Neck Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan 333604, TaiwanDepartment of Otolaryngology—Head and Neck Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan 333604, TaiwanMany patients diagnosed with empty nose syndrome (ENS) later develop mental illness. The literature addressing biomarkers associated with postoperative psychiatric status is limited. This study aimed to assess the association between high-sensitivity C-reactive protein (hs-CRP) and psychiatric status after surgery in ENS. We recruited patients with ENS undergoing endonasal submucosal implantation. Their pre- and postoperative psychiatric status was evaluated using the Beck depression inventory-II (BDI-II) and the Beck Anxiety Inventory (BAI). Serum hs-CRP was analyzed one day before and one year after surgery. Of the 43 patients enrolled, all subjective measurements had improved (symptom scores decreased) significantly by the third month postoperatively and remained plateaued till 12 months. Those with preoperative hs-CRP levels > 2.02 mg/L were likely to remain depressive 1 year postoperatively. The regression model showed that a preoperative hs-CRP level > 2.02 mg/L was significantly correlated with postoperative depression in patients with ENS (odds ratio, 19.9). Hs-CRP level seems to be a feasible predictor of surgical outcome regarding improved depression in patients with ENS. Patients with higher preoperative hs-CRP levels should be monitored closely after surgery.https://www.mdpi.com/2075-4418/11/12/2388high-sensitivity C-reactive protein (hs-CRP)empty nose syndromebiomarkerpsychiatricdepressionBeck depression inventory-II (BDI-II) |
| spellingShingle | Chia-Hsiang Fu Hung-Chin Chen Chi-Che Huang Po-Hung Chang Ta-Jen Lee Serum High-Sensitivity C-Reactive Protein Is Associated with Postoperative Psychiatric Status in Patients with Empty Nose Syndrome Diagnostics high-sensitivity C-reactive protein (hs-CRP) empty nose syndrome biomarker psychiatric depression Beck depression inventory-II (BDI-II) |
| title | Serum High-Sensitivity C-Reactive Protein Is Associated with Postoperative Psychiatric Status in Patients with Empty Nose Syndrome |
| title_full | Serum High-Sensitivity C-Reactive Protein Is Associated with Postoperative Psychiatric Status in Patients with Empty Nose Syndrome |
| title_fullStr | Serum High-Sensitivity C-Reactive Protein Is Associated with Postoperative Psychiatric Status in Patients with Empty Nose Syndrome |
| title_full_unstemmed | Serum High-Sensitivity C-Reactive Protein Is Associated with Postoperative Psychiatric Status in Patients with Empty Nose Syndrome |
| title_short | Serum High-Sensitivity C-Reactive Protein Is Associated with Postoperative Psychiatric Status in Patients with Empty Nose Syndrome |
| title_sort | serum high sensitivity c reactive protein is associated with postoperative psychiatric status in patients with empty nose syndrome |
| topic | high-sensitivity C-reactive protein (hs-CRP) empty nose syndrome biomarker psychiatric depression Beck depression inventory-II (BDI-II) |
| url | https://www.mdpi.com/2075-4418/11/12/2388 |
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