Structural Rearrangements of a Dodecameric Ketol-Acid Reductoisomerase Isolated from a Marine Thermophilic Methanogen

Structural Rearrangements of a Dodecameric Ketol-Acid Reductoisomerase Isolated from a Marine Thermophilic Methanogen

Ketol-acid reductoisomerase (KARI) orchestrates the biosynthesis of branched-chain amino acids, an elementary reaction in prototrophic organisms as well as a valuable process in biotechnology. Bacterial KARIs belonging to class I organise as dimers or dodecamers and were intensively studied to under...

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Bibliographic Details
Main Authors: Olivier Nicolas Lemaire, Marie-Caroline Müller, Jörg Kahnt, Tristan Wagner
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Biomolecules
Subjects:
ketol-acid reductoisomerases
methanogenic archaea
X-ray crystallography
conformational rearrangement
native purification
oligomerisation
Online Access:https://www.mdpi.com/2218-273X/11/11/1679

Internet

https://www.mdpi.com/2218-273X/11/11/1679

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