Design of a New Ultracompact Resonant Plasmonic Multi-Analyte Label-Free Biosensing Platform
In this paper, we report on the design of a bio-multisensing platform for the selective label-free detection of protein biomarkers, carried out through a 3D numerical algorithm. The platform includes a number of biosensors, each of them is based on a plasmonic nanocavity, consisting of a periodic me...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2017-08-01
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| Series: | Sensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8220/17/8/1810 |
| _version_ | 1828370736970989568 |
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| author | Francesco Dell’Olio Donato Conteduca Maripina De Palo Caterina Ciminelli |
| author_facet | Francesco Dell’Olio Donato Conteduca Maripina De Palo Caterina Ciminelli |
| author_sort | Francesco Dell’Olio |
| collection | DOAJ |
| description | In this paper, we report on the design of a bio-multisensing platform for the selective label-free detection of protein biomarkers, carried out through a 3D numerical algorithm. The platform includes a number of biosensors, each of them is based on a plasmonic nanocavity, consisting of a periodic metal structure to be deposited on a silicon oxide substrate. Light is strongly confined in a region with extremely small size (=1.57 μm2), to enhance the light-matter interaction. A surface sensitivity Ss = 1.8 nm/nm has been calculated together with a detection limit of 128 pg/mm2. Such performance, together with the extremely small footprint, allow the integration of several devices on a single chip to realize extremely compact lab-on-chip microsystems. In addition, each sensing element of the platform has a good chemical stability that is guaranteed by the selection of gold for its fabrication. |
| first_indexed | 2024-04-14T06:42:15Z |
| format | Article |
| id | doaj.art-abd6b7ac67da4e7990a1ded3fd1f563c |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-14T06:42:15Z |
| publishDate | 2017-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-abd6b7ac67da4e7990a1ded3fd1f563c2022-12-22T02:07:18ZengMDPI AGSensors1424-82202017-08-01178181010.3390/s17081810s17081810Design of a New Ultracompact Resonant Plasmonic Multi-Analyte Label-Free Biosensing PlatformFrancesco Dell’Olio0Donato Conteduca1Maripina De Palo2Caterina Ciminelli3Optoelectronic Laboratory, Politecnico di Bari, Via Orabona 4, 70125 Bari, ItalyOptoelectronic Laboratory, Politecnico di Bari, Via Orabona 4, 70125 Bari, ItalyOptoelectronic Laboratory, Politecnico di Bari, Via Orabona 4, 70125 Bari, ItalyOptoelectronic Laboratory, Politecnico di Bari, Via Orabona 4, 70125 Bari, ItalyIn this paper, we report on the design of a bio-multisensing platform for the selective label-free detection of protein biomarkers, carried out through a 3D numerical algorithm. The platform includes a number of biosensors, each of them is based on a plasmonic nanocavity, consisting of a periodic metal structure to be deposited on a silicon oxide substrate. Light is strongly confined in a region with extremely small size (=1.57 μm2), to enhance the light-matter interaction. A surface sensitivity Ss = 1.8 nm/nm has been calculated together with a detection limit of 128 pg/mm2. Such performance, together with the extremely small footprint, allow the integration of several devices on a single chip to realize extremely compact lab-on-chip microsystems. In addition, each sensing element of the platform has a good chemical stability that is guaranteed by the selection of gold for its fabrication.https://www.mdpi.com/1424-8220/17/8/1810biosensorplasmonicslabel-feeBragg grating |
| spellingShingle | Francesco Dell’Olio Donato Conteduca Maripina De Palo Caterina Ciminelli Design of a New Ultracompact Resonant Plasmonic Multi-Analyte Label-Free Biosensing Platform Sensors biosensor plasmonics label-fee Bragg grating |
| title | Design of a New Ultracompact Resonant Plasmonic Multi-Analyte Label-Free Biosensing Platform |
| title_full | Design of a New Ultracompact Resonant Plasmonic Multi-Analyte Label-Free Biosensing Platform |
| title_fullStr | Design of a New Ultracompact Resonant Plasmonic Multi-Analyte Label-Free Biosensing Platform |
| title_full_unstemmed | Design of a New Ultracompact Resonant Plasmonic Multi-Analyte Label-Free Biosensing Platform |
| title_short | Design of a New Ultracompact Resonant Plasmonic Multi-Analyte Label-Free Biosensing Platform |
| title_sort | design of a new ultracompact resonant plasmonic multi analyte label free biosensing platform |
| topic | biosensor plasmonics label-fee Bragg grating |
| url | https://www.mdpi.com/1424-8220/17/8/1810 |
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