Metabolic Engineering and Synthetic Biology Approaches for the Heterologous Production of Aromatic Polyketides
Polyketides are a diverse set of natural products with versatile applications as pharmaceuticals, nutraceuticals, and cosmetics, to name a few. Of several types of polyketides, aromatic polyketides comprising type II and III polyketides contain many chemicals important for human health such as antib...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/10/8923 |
| _version_ | 1797599757460307968 |
|---|---|
| author | Dongsoo Yang Hyunmin Eun Cindy Pricilia Surya Prabowo |
| author_facet | Dongsoo Yang Hyunmin Eun Cindy Pricilia Surya Prabowo |
| author_sort | Dongsoo Yang |
| collection | DOAJ |
| description | Polyketides are a diverse set of natural products with versatile applications as pharmaceuticals, nutraceuticals, and cosmetics, to name a few. Of several types of polyketides, aromatic polyketides comprising type II and III polyketides contain many chemicals important for human health such as antibiotics and anticancer agents. Most aromatic polyketides are produced from soil bacteria or plants, which are difficult to engineer and grow slowly in industrial settings. To this end, metabolic engineering and synthetic biology have been employed to efficiently engineer heterologous model microorganisms for enhanced production of important aromatic polyketides. In this review, we discuss the recent advancement in metabolic engineering and synthetic biology strategies for the production of type II and type III polyketides in model microorganisms. Future challenges and prospects of aromatic polyketide biosynthesis by synthetic biology and enzyme engineering approaches are also discussed. |
| first_indexed | 2024-03-11T03:39:50Z |
| format | Article |
| id | doaj.art-abd7504dcc0a4a24b73e5bdb1d68a0d2 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T03:39:50Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-abd7504dcc0a4a24b73e5bdb1d68a0d22023-11-18T01:44:18ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-05-012410892310.3390/ijms24108923Metabolic Engineering and Synthetic Biology Approaches for the Heterologous Production of Aromatic PolyketidesDongsoo Yang0Hyunmin Eun1Cindy Pricilia Surya Prabowo2Synthetic Biology and Enzyme Engineering Laboratory, Department of Chemical and Biological Engineering (BK21 Four), Korea University, Seoul 02481, Republic of KoreaMetabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 Four), Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of KoreaMetabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 Four), Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of KoreaPolyketides are a diverse set of natural products with versatile applications as pharmaceuticals, nutraceuticals, and cosmetics, to name a few. Of several types of polyketides, aromatic polyketides comprising type II and III polyketides contain many chemicals important for human health such as antibiotics and anticancer agents. Most aromatic polyketides are produced from soil bacteria or plants, which are difficult to engineer and grow slowly in industrial settings. To this end, metabolic engineering and synthetic biology have been employed to efficiently engineer heterologous model microorganisms for enhanced production of important aromatic polyketides. In this review, we discuss the recent advancement in metabolic engineering and synthetic biology strategies for the production of type II and type III polyketides in model microorganisms. Future challenges and prospects of aromatic polyketide biosynthesis by synthetic biology and enzyme engineering approaches are also discussed.https://www.mdpi.com/1422-0067/24/10/8923aromatic polyketideenzyme engineeringmetabolic engineeringpolyketidepolyketide synthasesynthetic biology |
| spellingShingle | Dongsoo Yang Hyunmin Eun Cindy Pricilia Surya Prabowo Metabolic Engineering and Synthetic Biology Approaches for the Heterologous Production of Aromatic Polyketides International Journal of Molecular Sciences aromatic polyketide enzyme engineering metabolic engineering polyketide polyketide synthase synthetic biology |
| title | Metabolic Engineering and Synthetic Biology Approaches for the Heterologous Production of Aromatic Polyketides |
| title_full | Metabolic Engineering and Synthetic Biology Approaches for the Heterologous Production of Aromatic Polyketides |
| title_fullStr | Metabolic Engineering and Synthetic Biology Approaches for the Heterologous Production of Aromatic Polyketides |
| title_full_unstemmed | Metabolic Engineering and Synthetic Biology Approaches for the Heterologous Production of Aromatic Polyketides |
| title_short | Metabolic Engineering and Synthetic Biology Approaches for the Heterologous Production of Aromatic Polyketides |
| title_sort | metabolic engineering and synthetic biology approaches for the heterologous production of aromatic polyketides |
| topic | aromatic polyketide enzyme engineering metabolic engineering polyketide polyketide synthase synthetic biology |
| url | https://www.mdpi.com/1422-0067/24/10/8923 |
| work_keys_str_mv | AT dongsooyang metabolicengineeringandsyntheticbiologyapproachesfortheheterologousproductionofaromaticpolyketides AT hyunmineun metabolicengineeringandsyntheticbiologyapproachesfortheheterologousproductionofaromaticpolyketides AT cindypriciliasuryaprabowo metabolicengineeringandsyntheticbiologyapproachesfortheheterologousproductionofaromaticpolyketides |