The association between Interleukin-1β gene polymorphisms and the risk of breast cancer: a systematic review and meta-analysis
Introduction It is reported that there is a close association between interleukin-1β (IL-1β) gene polymorphisms and breast cancer risk. However, the results remain controversial. Material and methods Eligible published articles were searched in PubMed, Embase, and Web of Science databases up to Jun...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2021-03-01
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| Series: | Archives of Medical Science |
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| Online Access: | https://www.archivesofmedicalscience.com/The-association-between-Interleukin-1-gene-polymorphisms-and-the-risk-of-breast-cancer,99839,0,2.html |
| _version_ | 1811203220830158848 |
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| author | Bei Wang Fenlai Yuan |
| author_facet | Bei Wang Fenlai Yuan |
| author_sort | Bei Wang |
| collection | DOAJ |
| description | Introduction
It is reported that there is a close association between interleukin-1β (IL-1β) gene polymorphisms and breast cancer risk. However, the results remain controversial.
Material and methods
Eligible published articles were searched in PubMed, Embase, and Web of Science databases up to June 2018. Odds ratios with 95% confidence intervals were used to identify potential links between IL-1β genetic polymorphisms and the risk of breast cancer.
Results
From our results, we found that three common polymorphisms in IL-1β (rs16944, rs1143634, rs1143627) had no significant associations with breast cancer risk in all genetic models. Based on the analysis from ethnic subgroups, there was a higher risk of breast cancer for rs16944 polymorphism in the recessive model and heterozygous model among Asians (TT vs. CC+CT: 1.229, 95% CI: 1.063–1.422, p = 0.005; TT vs. CT: 1.211, 95% CI: 1.057–1.388, p = 0.006). For the rs1143627 polymorphism, a significantly decreased breast cancer risk was observed in the dominant model only in Asians (CT+TT vs. CC: OR = 0.944, 95% CI: 0.897–0.994, p = 0.027). After stratifying patients according to the menopausal state, we found that polymorphism of rs1143627 correlated with reduced breast cancer risk among post-menopausal women in three genotype models: allele, recessive model and homozygous model (T vs C: 0.859, 95% CI: 0.753–0.98, p = 0.024; TT vs. CC+CT: 0.727, 95% CI: 0.576–0.918, p = 0.007; TT vs. CC: 0.743, 95% CI: 0.626–0.882, p = 0.001). As for other analyses with reference to source of controls and genotyping methods, no significant association between IL-1β polymorphism and breast cancer risk was demonstrated.
Conclusions
The rs16944 and rs1143627 polymorphisms are significantly associated with the risk of breast cancer only in Asian people and in post- menopausal women respectively. |
| first_indexed | 2024-04-12T02:52:06Z |
| format | Article |
| id | doaj.art-abd8183e93044c369b31366633d03362 |
| institution | Directory Open Access Journal |
| issn | 1734-1922 1896-9151 |
| language | English |
| last_indexed | 2024-04-12T02:52:06Z |
| publishDate | 2021-03-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj.art-abd8183e93044c369b31366633d033622022-12-22T03:50:58ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512021-03-0118111010.5114/aoms/9983999839The association between Interleukin-1β gene polymorphisms and the risk of breast cancer: a systematic review and meta-analysisBei Wang0Fenlai Yuan1Department of Central Laboratory, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, ChinaDepartment of Central Laboratory, The Hospital Affiliated to Jiangnan University, Wuxi, Jiangsu, ChinaIntroduction It is reported that there is a close association between interleukin-1β (IL-1β) gene polymorphisms and breast cancer risk. However, the results remain controversial. Material and methods Eligible published articles were searched in PubMed, Embase, and Web of Science databases up to June 2018. Odds ratios with 95% confidence intervals were used to identify potential links between IL-1β genetic polymorphisms and the risk of breast cancer. Results From our results, we found that three common polymorphisms in IL-1β (rs16944, rs1143634, rs1143627) had no significant associations with breast cancer risk in all genetic models. Based on the analysis from ethnic subgroups, there was a higher risk of breast cancer for rs16944 polymorphism in the recessive model and heterozygous model among Asians (TT vs. CC+CT: 1.229, 95% CI: 1.063–1.422, p = 0.005; TT vs. CT: 1.211, 95% CI: 1.057–1.388, p = 0.006). For the rs1143627 polymorphism, a significantly decreased breast cancer risk was observed in the dominant model only in Asians (CT+TT vs. CC: OR = 0.944, 95% CI: 0.897–0.994, p = 0.027). After stratifying patients according to the menopausal state, we found that polymorphism of rs1143627 correlated with reduced breast cancer risk among post-menopausal women in three genotype models: allele, recessive model and homozygous model (T vs C: 0.859, 95% CI: 0.753–0.98, p = 0.024; TT vs. CC+CT: 0.727, 95% CI: 0.576–0.918, p = 0.007; TT vs. CC: 0.743, 95% CI: 0.626–0.882, p = 0.001). As for other analyses with reference to source of controls and genotyping methods, no significant association between IL-1β polymorphism and breast cancer risk was demonstrated. Conclusions The rs16944 and rs1143627 polymorphisms are significantly associated with the risk of breast cancer only in Asian people and in post- menopausal women respectively.https://www.archivesofmedicalscience.com/The-association-between-Interleukin-1-gene-polymorphisms-and-the-risk-of-breast-cancer,99839,0,2.htmlpolymorphismbreast cancerinterleukin-1βmeta-analysis |
| spellingShingle | Bei Wang Fenlai Yuan The association between Interleukin-1β gene polymorphisms and the risk of breast cancer: a systematic review and meta-analysis Archives of Medical Science polymorphism breast cancer interleukin-1β meta-analysis |
| title | The association between Interleukin-1β gene polymorphisms and the risk of breast cancer: a systematic review and meta-analysis |
| title_full | The association between Interleukin-1β gene polymorphisms and the risk of breast cancer: a systematic review and meta-analysis |
| title_fullStr | The association between Interleukin-1β gene polymorphisms and the risk of breast cancer: a systematic review and meta-analysis |
| title_full_unstemmed | The association between Interleukin-1β gene polymorphisms and the risk of breast cancer: a systematic review and meta-analysis |
| title_short | The association between Interleukin-1β gene polymorphisms and the risk of breast cancer: a systematic review and meta-analysis |
| title_sort | association between interleukin 1β gene polymorphisms and the risk of breast cancer a systematic review and meta analysis |
| topic | polymorphism breast cancer interleukin-1β meta-analysis |
| url | https://www.archivesofmedicalscience.com/The-association-between-Interleukin-1-gene-polymorphisms-and-the-risk-of-breast-cancer,99839,0,2.html |
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