Computational-Driven Epitope Verification and Affinity Maturation of TLR4-Targeting Antibodies

Computational-Driven Epitope Verification and Affinity Maturation of TLR4-Targeting Antibodies

Toll-like receptor (TLR) signaling plays a critical role in the induction and progression of autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematous, experimental autoimmune encephalitis, type 1 diabetes mellitus and neurodegenerative diseases. Deciphering antigen recognition b...

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Bibliographic Details
Main Authors: Bilal Ahmad, Maria Batool, Moon-Suk Kim, Sangdun Choi
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
antibody
epitope
molecular dynamics
mutation
toll-like receptor
Online Access:https://www.mdpi.com/1422-0067/22/11/5989

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