Peripheral and central mechanisms of stress resilience
Viable new treatments for depression and anxiety have been slow to emerge, likely owing to the complex and incompletely understood etiology of these disorders. A budding area of research with great therapeutic promise involves the study of resilience, the adaptive maintenance of normal physiology an...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2015-01-01
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| Series: | Neurobiology of Stress |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352289514000058 |
| _version_ | 1818307009202618368 |
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| author | Madeline L. Pfau Scott J. Russo |
| author_facet | Madeline L. Pfau Scott J. Russo |
| author_sort | Madeline L. Pfau |
| collection | DOAJ |
| description | Viable new treatments for depression and anxiety have been slow to emerge, likely owing to the complex and incompletely understood etiology of these disorders. A budding area of research with great therapeutic promise involves the study of resilience, the adaptive maintenance of normal physiology and behavior despite exposure to marked psychological stress. This phenomenon, documented in both humans and animal models, involves coordinated biological mechanisms in numerous bodily systems, both peripheral and central. In this review, we provide an overview of resilience mechanisms throughout the body, discussing current research in animal models investigating the roles of the neuroendocrine, immune, and central nervous systems in behavioral resilience to stress. |
| first_indexed | 2024-12-13T06:51:34Z |
| format | Article |
| id | doaj.art-abd8c39fe465489cbc4f8f94344390ab |
| institution | Directory Open Access Journal |
| issn | 2352-2895 |
| language | English |
| last_indexed | 2024-12-13T06:51:34Z |
| publishDate | 2015-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Stress |
| spelling | doaj.art-abd8c39fe465489cbc4f8f94344390ab2022-12-21T23:56:08ZengElsevierNeurobiology of Stress2352-28952015-01-011C667910.1016/j.ynstr.2014.09.004Peripheral and central mechanisms of stress resilienceMadeline L. Pfau0Scott J. Russo1Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USAFishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USAViable new treatments for depression and anxiety have been slow to emerge, likely owing to the complex and incompletely understood etiology of these disorders. A budding area of research with great therapeutic promise involves the study of resilience, the adaptive maintenance of normal physiology and behavior despite exposure to marked psychological stress. This phenomenon, documented in both humans and animal models, involves coordinated biological mechanisms in numerous bodily systems, both peripheral and central. In this review, we provide an overview of resilience mechanisms throughout the body, discussing current research in animal models investigating the roles of the neuroendocrine, immune, and central nervous systems in behavioral resilience to stress.http://www.sciencedirect.com/science/article/pii/S2352289514000058ResilienceStressDepressionAnxietyNeuroimmunePlasticity |
| spellingShingle | Madeline L. Pfau Scott J. Russo Peripheral and central mechanisms of stress resilience Neurobiology of Stress Resilience Stress Depression Anxiety Neuroimmune Plasticity |
| title | Peripheral and central mechanisms of stress resilience |
| title_full | Peripheral and central mechanisms of stress resilience |
| title_fullStr | Peripheral and central mechanisms of stress resilience |
| title_full_unstemmed | Peripheral and central mechanisms of stress resilience |
| title_short | Peripheral and central mechanisms of stress resilience |
| title_sort | peripheral and central mechanisms of stress resilience |
| topic | Resilience Stress Depression Anxiety Neuroimmune Plasticity |
| url | http://www.sciencedirect.com/science/article/pii/S2352289514000058 |
| work_keys_str_mv | AT madelinelpfau peripheralandcentralmechanismsofstressresilience AT scottjrusso peripheralandcentralmechanismsofstressresilience |