Case study: Targeted RNA-sequencing of aged formalin-fixed paraffin-embedded samples for understanding chemical mode of action

Case study: Targeted RNA-sequencing of aged formalin-fixed paraffin-embedded samples for understanding chemical mode of action

Formalin-fixed paraffin-embedded (FFPE) samples are the only remaining biological archive for many toxicological and clinical studies, yet their use in genomics has been limited due to nucleic acid damage from formalin fixation. Older FFPE samples with highly degraded RNA pose a particularly difficu...

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Bibliographic Details
Main Authors: Michael D. Cannizzo, Charles E. Wood, Susan D. Hester, Leah C. Wehmas
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Toxicology Reports
Subjects:
Formalin-fixed paraffin-embedded (FFPE)
RNA-Seq
TempO-Seq
Dichloroacetic acid
DCA
Benchmark dose (BMD) analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750022000956

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