White matter changes following electroconvulsive therapy for depression: a mega-analysis
Introduction Electroconvulsive therapy (ECT) is proposed to exert an effect on white matter (WM) microstructure, but the limited power of previous studies made it difficult to highlight consistent patterns of change in diffusion metrics. Objectives We initiated a multi-site mega-analysis and sough...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-06-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822002371/type/journal_article |
| _version_ | 1797616224406863872 |
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| author | J.-B. Belge P. Mulders L. Van Diermen A. Dols M. Oudega I. Tendolkar P. Van Eijndhoven |
| author_facet | J.-B. Belge P. Mulders L. Van Diermen A. Dols M. Oudega I. Tendolkar P. Van Eijndhoven |
| author_sort | J.-B. Belge |
| collection | DOAJ |
| description |
Introduction
Electroconvulsive therapy (ECT) is proposed to exert an effect on white matter (WM) microstructure, but the limited power of previous studies made it difficult to highlight consistent patterns of change in diffusion metrics.
Objectives
We initiated a multi-site mega-analysis and sought to address whether changes in WM microstructure occur following ECT.
Methods
To this end, diffusion tensor imaging (DTI) data (n=58) from 4 different sites were harmonized before pooling them by using ComBat, a batch-effect correction tool that removes inter-site technical variability, preserves inter-site biological variability and maximizes statistical power. Downstream statistical analyses aimed to quantify changes in Fractional anisotropy (FA), Mean Diffusivity (MD), Radial Diffusivity (RD) and Axial Diffusivity (AD), by employing whole-brain, tract-based spatial statistics (TBSS).
Results
ECT increases FA in the right splenium of the corpus callosum and the left cortico-spinal tract. Both the left superior longitudinal fasciculus and the right inferior fronto-occipital fasciculus showed increases in AD. Increases in MD and RD could be observed in overlapping white matter structures of both hemispheres. Finally, responders showed significantly smaller FA values in the left forceps major and smaller AD values in the right uncinate fasciculus compared with non-responders.
Conclusions
This is the first and largest multi-site mega-analysis to demonstrate that ECT normalizes altered WM microstructure in important brain circuits that are implicated in the pathophysiology of depression. Furthermore, responders appear to present a more decreased WM integrity at baseline, which if replicated could serve as a biomarker for ECT response.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:37:17Z |
| format | Article |
| id | doaj.art-abd93e90aa454849bd2087adc0a07357 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:37:17Z |
| publishDate | 2022-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-abd93e90aa454849bd2087adc0a073572023-11-17T05:09:14ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-06-0165S77S7710.1192/j.eurpsy.2022.237White matter changes following electroconvulsive therapy for depression: a mega-analysisJ.-B. Belge0P. Mulders1L. Van Diermen2A. Dols3M. Oudega4I. Tendolkar5P. Van Eijndhoven6University of Antwerp, Collaborative Antwerp Psychiatric Research Institute (capri), Duffel, BelgiumRadboud University Medical Center, Donders Institute For Brain, Cognition And Behavior, Centre For Neuroscience, Nijmegen, NetherlandsUniversity of Antwerp, Collaborative Antwerp Psychiatric Research Institute (capri), Duffel, BelgiumAmsterdam University Medical Center, Amsterdam Neuroscience, Amsterdam, NetherlandsAmsterdam University Medical Center, Amsterdam Neuroscience, Amsterdam, NetherlandsRadboud University Medical Center, Donders Institute For Brain, Cognition And Behavior, Centre For Neuroscience, Nijmegen, NetherlandsRadboud University Medical Center, Donders Institute For Brain, Cognition And Behavior, Centre For Neuroscience, Nijmegen, Netherlands Introduction Electroconvulsive therapy (ECT) is proposed to exert an effect on white matter (WM) microstructure, but the limited power of previous studies made it difficult to highlight consistent patterns of change in diffusion metrics. Objectives We initiated a multi-site mega-analysis and sought to address whether changes in WM microstructure occur following ECT. Methods To this end, diffusion tensor imaging (DTI) data (n=58) from 4 different sites were harmonized before pooling them by using ComBat, a batch-effect correction tool that removes inter-site technical variability, preserves inter-site biological variability and maximizes statistical power. Downstream statistical analyses aimed to quantify changes in Fractional anisotropy (FA), Mean Diffusivity (MD), Radial Diffusivity (RD) and Axial Diffusivity (AD), by employing whole-brain, tract-based spatial statistics (TBSS). Results ECT increases FA in the right splenium of the corpus callosum and the left cortico-spinal tract. Both the left superior longitudinal fasciculus and the right inferior fronto-occipital fasciculus showed increases in AD. Increases in MD and RD could be observed in overlapping white matter structures of both hemispheres. Finally, responders showed significantly smaller FA values in the left forceps major and smaller AD values in the right uncinate fasciculus compared with non-responders. Conclusions This is the first and largest multi-site mega-analysis to demonstrate that ECT normalizes altered WM microstructure in important brain circuits that are implicated in the pathophysiology of depression. Furthermore, responders appear to present a more decreased WM integrity at baseline, which if replicated could serve as a biomarker for ECT response. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933822002371/type/journal_articleDiffusion Tensor ImagingElectroconvulsive therapyTract-Based Spatial StatisticsDepression |
| spellingShingle | J.-B. Belge P. Mulders L. Van Diermen A. Dols M. Oudega I. Tendolkar P. Van Eijndhoven White matter changes following electroconvulsive therapy for depression: a mega-analysis European Psychiatry Diffusion Tensor Imaging Electroconvulsive therapy Tract-Based Spatial Statistics Depression |
| title | White matter changes following electroconvulsive therapy for depression: a mega-analysis |
| title_full | White matter changes following electroconvulsive therapy for depression: a mega-analysis |
| title_fullStr | White matter changes following electroconvulsive therapy for depression: a mega-analysis |
| title_full_unstemmed | White matter changes following electroconvulsive therapy for depression: a mega-analysis |
| title_short | White matter changes following electroconvulsive therapy for depression: a mega-analysis |
| title_sort | white matter changes following electroconvulsive therapy for depression a mega analysis |
| topic | Diffusion Tensor Imaging Electroconvulsive therapy Tract-Based Spatial Statistics Depression |
| url | https://www.cambridge.org/core/product/identifier/S0924933822002371/type/journal_article |
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