Inflammation-Induced Tumorigenesis and Metastasis
Inflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and metastasis through various mechanisms and is now recognized as a hallmark of cancer and an attractive therapeutic target in cancer. In this review, we discuss recent advances in molecular mechanisms of how infla...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/11/5421 |
| _version_ | 1797533294534852608 |
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| author | Sana Hibino Tetsuro Kawazoe Hidenori Kasahara Shinji Itoh Takatsugu Ishimoto Mamiko Sakata-Yanagimoto Koji Taniguchi |
| author_facet | Sana Hibino Tetsuro Kawazoe Hidenori Kasahara Shinji Itoh Takatsugu Ishimoto Mamiko Sakata-Yanagimoto Koji Taniguchi |
| author_sort | Sana Hibino |
| collection | DOAJ |
| description | Inflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and metastasis through various mechanisms and is now recognized as a hallmark of cancer and an attractive therapeutic target in cancer. In this review, we discuss recent advances in molecular mechanisms of how inflammation promotes tumorigenesis and metastasis and suppresses anti-tumor immunity in various types of solid tumors, including esophageal, gastric, colorectal, liver, and pancreatic cancer as well as hematopoietic malignancies. |
| first_indexed | 2024-03-10T11:12:30Z |
| format | Article |
| id | doaj.art-abdaf0f4ed834cedbb9a5fbfe97fa79e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T11:12:30Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-abdaf0f4ed834cedbb9a5fbfe97fa79e2023-11-21T20:42:24ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-012211542110.3390/ijms22115421Inflammation-Induced Tumorigenesis and MetastasisSana Hibino0Tetsuro Kawazoe1Hidenori Kasahara2Shinji Itoh3Takatsugu Ishimoto4Mamiko Sakata-Yanagimoto5Koji Taniguchi6Research Center for Advanced Science and Technology, Department of Inflammology, The University of Tokyo, Tokyo 153-0041, JapanDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo 160-8582, JapanNational Center for Global Health and Medicine, Department of Stem Cell Biology, Research Institute, Tokyo 162-8655, JapanDepartment of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, JapanGastrointestinal Cancer Biology, International Research Center of Medical Sciences (IRCMS), Kumamoto University, Kumamoto 860-0811, JapanDepartment of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, JapanDepartment of Microbiology and Immunology, Keio University School of Medicine, Tokyo 160-8582, JapanInflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and metastasis through various mechanisms and is now recognized as a hallmark of cancer and an attractive therapeutic target in cancer. In this review, we discuss recent advances in molecular mechanisms of how inflammation promotes tumorigenesis and metastasis and suppresses anti-tumor immunity in various types of solid tumors, including esophageal, gastric, colorectal, liver, and pancreatic cancer as well as hematopoietic malignancies.https://www.mdpi.com/1422-0067/22/11/5421inflammationcancermetastasistumor microenvironmentimmunosuppression |
| spellingShingle | Sana Hibino Tetsuro Kawazoe Hidenori Kasahara Shinji Itoh Takatsugu Ishimoto Mamiko Sakata-Yanagimoto Koji Taniguchi Inflammation-Induced Tumorigenesis and Metastasis International Journal of Molecular Sciences inflammation cancer metastasis tumor microenvironment immunosuppression |
| title | Inflammation-Induced Tumorigenesis and Metastasis |
| title_full | Inflammation-Induced Tumorigenesis and Metastasis |
| title_fullStr | Inflammation-Induced Tumorigenesis and Metastasis |
| title_full_unstemmed | Inflammation-Induced Tumorigenesis and Metastasis |
| title_short | Inflammation-Induced Tumorigenesis and Metastasis |
| title_sort | inflammation induced tumorigenesis and metastasis |
| topic | inflammation cancer metastasis tumor microenvironment immunosuppression |
| url | https://www.mdpi.com/1422-0067/22/11/5421 |
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