Insulin Resistance: A Marker for Fat-to-Lean Body Composition in Japanese Adults
We sought to investigate the relationship between insulin resistance (IR) and body composition as assessed by bioelectrical impedance analysis in Japanese health check-up recipients (1186 men and 1441 women). IR was defined as a Homeostasis Model Assessment of IR (HOMA-IR) ≥ 2.5. In body-composition...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/22/4724 |
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| author | Masahiro Matsui Akira Fukuda Saori Onishi Kosuke Ushiro Tomohiro Nishikawa Akira Asai Soo Ki Kim Hiroki Nishikawa |
| author_facet | Masahiro Matsui Akira Fukuda Saori Onishi Kosuke Ushiro Tomohiro Nishikawa Akira Asai Soo Ki Kim Hiroki Nishikawa |
| author_sort | Masahiro Matsui |
| collection | DOAJ |
| description | We sought to investigate the relationship between insulin resistance (IR) and body composition as assessed by bioelectrical impedance analysis in Japanese health check-up recipients (1186 men and 1441 women). IR was defined as a Homeostasis Model Assessment of IR (HOMA-IR) ≥ 2.5. In body-composition-related parameters, the fat mass index (F index) was defined as fat mass divided by the height squared (kg/m<sup>2</sup>). The fat-free mass index (FF index) was defined as fat-free mass divided by the height squared (kg/m<sup>2</sup>). The F index to FF index ratio (F-FF ratio) was defined as the F index divided by the FF index. Factors related to HOMA-IR were examined. The median HOMA-IR was 1.54 in men and 1.30 in women (<i>p</i> < 0.0001). The median F index was 4.9 kg/m<sup>2</sup> in men and 6.1 kg/m<sup>2</sup> in women (<i>p</i> < 0.0001). The median FF index was 18.2 kg/m<sup>2</sup> in men and 15.1 kg/m<sup>2</sup> in women (<i>p</i> < 0.0001). The median F-FF ratio was 0.272 in men and 0.405 in women (<i>p</i> < 0.0001). The F-FF ratio was an independent factor associated with HOMA-IR in the multivariate analysis in both genders, while the F index and FF index were not in both genders. In conclusion, fat and skeletal muscle balance can be controlled by IR in Japanese adults. |
| first_indexed | 2024-03-09T16:33:33Z |
| format | Article |
| id | doaj.art-abdb74608bf342d093faffc25f11d00b |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T16:33:33Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-abdb74608bf342d093faffc25f11d00b2023-11-24T14:59:05ZengMDPI AGNutrients2072-66432023-11-011522472410.3390/nu15224724Insulin Resistance: A Marker for Fat-to-Lean Body Composition in Japanese AdultsMasahiro Matsui0Akira Fukuda1Saori Onishi2Kosuke Ushiro3Tomohiro Nishikawa4Akira Asai5Soo Ki Kim6Hiroki Nishikawa7Second Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Takatsuki 569-8686, JapanHealth Science Clinic, Osaka Medical and Pharmaceutical University, Takatsuki 569-8686, JapanSecond Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Takatsuki 569-8686, JapanSecond Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Takatsuki 569-8686, JapanSecond Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Takatsuki 569-8686, JapanSecond Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Takatsuki 569-8686, JapanDepartment of Gastroenterology, Kobe Asahi Hospital, Kobe 653-8501, JapanSecond Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Takatsuki 569-8686, JapanWe sought to investigate the relationship between insulin resistance (IR) and body composition as assessed by bioelectrical impedance analysis in Japanese health check-up recipients (1186 men and 1441 women). IR was defined as a Homeostasis Model Assessment of IR (HOMA-IR) ≥ 2.5. In body-composition-related parameters, the fat mass index (F index) was defined as fat mass divided by the height squared (kg/m<sup>2</sup>). The fat-free mass index (FF index) was defined as fat-free mass divided by the height squared (kg/m<sup>2</sup>). The F index to FF index ratio (F-FF ratio) was defined as the F index divided by the FF index. Factors related to HOMA-IR were examined. The median HOMA-IR was 1.54 in men and 1.30 in women (<i>p</i> < 0.0001). The median F index was 4.9 kg/m<sup>2</sup> in men and 6.1 kg/m<sup>2</sup> in women (<i>p</i> < 0.0001). The median FF index was 18.2 kg/m<sup>2</sup> in men and 15.1 kg/m<sup>2</sup> in women (<i>p</i> < 0.0001). The median F-FF ratio was 0.272 in men and 0.405 in women (<i>p</i> < 0.0001). The F-FF ratio was an independent factor associated with HOMA-IR in the multivariate analysis in both genders, while the F index and FF index were not in both genders. In conclusion, fat and skeletal muscle balance can be controlled by IR in Japanese adults.https://www.mdpi.com/2072-6643/15/22/4724insulin resistancefatskeletal musclefat and muscle balanceJapanese adults |
| spellingShingle | Masahiro Matsui Akira Fukuda Saori Onishi Kosuke Ushiro Tomohiro Nishikawa Akira Asai Soo Ki Kim Hiroki Nishikawa Insulin Resistance: A Marker for Fat-to-Lean Body Composition in Japanese Adults Nutrients insulin resistance fat skeletal muscle fat and muscle balance Japanese adults |
| title | Insulin Resistance: A Marker for Fat-to-Lean Body Composition in Japanese Adults |
| title_full | Insulin Resistance: A Marker for Fat-to-Lean Body Composition in Japanese Adults |
| title_fullStr | Insulin Resistance: A Marker for Fat-to-Lean Body Composition in Japanese Adults |
| title_full_unstemmed | Insulin Resistance: A Marker for Fat-to-Lean Body Composition in Japanese Adults |
| title_short | Insulin Resistance: A Marker for Fat-to-Lean Body Composition in Japanese Adults |
| title_sort | insulin resistance a marker for fat to lean body composition in japanese adults |
| topic | insulin resistance fat skeletal muscle fat and muscle balance Japanese adults |
| url | https://www.mdpi.com/2072-6643/15/22/4724 |
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