Brain Stimulation in Alzheimer's Disease
Brain stimulation techniques can modulate cognitive functions in many neuropsychiatric diseases. Pilot studies have shown promising effects of brain stimulations on Alzheimer's disease (AD). Brain stimulations can be categorized into non-invasive brain stimulation (NIBS) and invasive brain stim...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-05-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2018.00201/full |
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| author | Chun-Hung Chang Chun-Hung Chang Hsien-Yuan Lane Hsien-Yuan Lane Hsien-Yuan Lane Hsien-Yuan Lane Chieh-Hsin Lin Chieh-Hsin Lin Chieh-Hsin Lin |
| author_facet | Chun-Hung Chang Chun-Hung Chang Hsien-Yuan Lane Hsien-Yuan Lane Hsien-Yuan Lane Hsien-Yuan Lane Chieh-Hsin Lin Chieh-Hsin Lin Chieh-Hsin Lin |
| author_sort | Chun-Hung Chang |
| collection | DOAJ |
| description | Brain stimulation techniques can modulate cognitive functions in many neuropsychiatric diseases. Pilot studies have shown promising effects of brain stimulations on Alzheimer's disease (AD). Brain stimulations can be categorized into non-invasive brain stimulation (NIBS) and invasive brain stimulation (IBS). IBS includes deep brain stimulation (DBS), and invasive vagus nerve stimulation (VNS), whereas NIBS includes transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), electroconvulsive treatment (ECT), magnetic seizure therapy (MST), cranial electrostimulation (CES), and non-invasive VNS. We reviewed the cutting-edge research on these brain stimulation techniques and discussed their therapeutic effects on AD. Both IBS and NIBS may have potential to be developed as novel treatments for AD; however, mixed findings may result from different study designs, patients selection, population, or samples sizes. Therefore, the efficacy of NIBS and IBS in AD remains uncertain, and needs to be further investigated. Moreover, more standardized study designs with larger sample sizes and longitudinal follow-up are warranted for establishing a structural guide for future studies and clinical application. |
| first_indexed | 2024-12-13T10:46:13Z |
| format | Article |
| id | doaj.art-abdb93e69d5043cb9f382924887e1ddd |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-13T10:46:13Z |
| publishDate | 2018-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-abdb93e69d5043cb9f382924887e1ddd2022-12-21T23:50:10ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402018-05-01910.3389/fpsyt.2018.00201329705Brain Stimulation in Alzheimer's DiseaseChun-Hung Chang0Chun-Hung Chang1Hsien-Yuan Lane2Hsien-Yuan Lane3Hsien-Yuan Lane4Hsien-Yuan Lane5Chieh-Hsin Lin6Chieh-Hsin Lin7Chieh-Hsin Lin8Institute of Clinical Medical Science, China Medical University, Taichung, TaiwanDepartment of Psychiatry & Brain Disease Research Center, China Medical University Hospital, Taichung, TaiwanInstitute of Clinical Medical Science, China Medical University, Taichung, TaiwanDepartment of Psychiatry & Brain Disease Research Center, China Medical University Hospital, Taichung, TaiwanGraduate Institute of Biomedical Sciences, China Medical University, Taichung, TaiwanDepartment of Psychology, College of Medical and Health Sciences, Asia University, Taichung, TaiwanInstitute of Clinical Medical Science, China Medical University, Taichung, TaiwanGraduate Institute of Biomedical Sciences, China Medical University, Taichung, TaiwanKaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, TaiwanBrain stimulation techniques can modulate cognitive functions in many neuropsychiatric diseases. Pilot studies have shown promising effects of brain stimulations on Alzheimer's disease (AD). Brain stimulations can be categorized into non-invasive brain stimulation (NIBS) and invasive brain stimulation (IBS). IBS includes deep brain stimulation (DBS), and invasive vagus nerve stimulation (VNS), whereas NIBS includes transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), electroconvulsive treatment (ECT), magnetic seizure therapy (MST), cranial electrostimulation (CES), and non-invasive VNS. We reviewed the cutting-edge research on these brain stimulation techniques and discussed their therapeutic effects on AD. Both IBS and NIBS may have potential to be developed as novel treatments for AD; however, mixed findings may result from different study designs, patients selection, population, or samples sizes. Therefore, the efficacy of NIBS and IBS in AD remains uncertain, and needs to be further investigated. Moreover, more standardized study designs with larger sample sizes and longitudinal follow-up are warranted for establishing a structural guide for future studies and clinical application.https://www.frontiersin.org/article/10.3389/fpsyt.2018.00201/fullbrain stimulationAlzheimer's disease (AD)transcranial magnetic stimulation (TMS)transcranial direct current stimulation (tDCS)transcranial alternating current stimulation (tACS)electroconvulsive treatment (ECT) |
| spellingShingle | Chun-Hung Chang Chun-Hung Chang Hsien-Yuan Lane Hsien-Yuan Lane Hsien-Yuan Lane Hsien-Yuan Lane Chieh-Hsin Lin Chieh-Hsin Lin Chieh-Hsin Lin Brain Stimulation in Alzheimer's Disease Frontiers in Psychiatry brain stimulation Alzheimer's disease (AD) transcranial magnetic stimulation (TMS) transcranial direct current stimulation (tDCS) transcranial alternating current stimulation (tACS) electroconvulsive treatment (ECT) |
| title | Brain Stimulation in Alzheimer's Disease |
| title_full | Brain Stimulation in Alzheimer's Disease |
| title_fullStr | Brain Stimulation in Alzheimer's Disease |
| title_full_unstemmed | Brain Stimulation in Alzheimer's Disease |
| title_short | Brain Stimulation in Alzheimer's Disease |
| title_sort | brain stimulation in alzheimer s disease |
| topic | brain stimulation Alzheimer's disease (AD) transcranial magnetic stimulation (TMS) transcranial direct current stimulation (tDCS) transcranial alternating current stimulation (tACS) electroconvulsive treatment (ECT) |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2018.00201/full |
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