Therapeutic Drug Monitoring of Antiseizure Medications Using Volumetric Absorptive Microsampling: Where Are We?
Therapeutic drug monitoring (TDM) of antiseizure medications (ASMs) represents a valuable tool to establish an appropriate patient therapy, to collect important information about drugs’ interactions and to evaluate patient’s metabolic capabilities. In recent years, a new volumetric absorptive micros...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/7/627 |
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| author | Annachiara D’Urso Marcello Locatelli Angela Tartaglia Linda Molteni Cristian D’Ovidio Fabio Savini James Rudge Ugo de Grazia |
| author_facet | Annachiara D’Urso Marcello Locatelli Angela Tartaglia Linda Molteni Cristian D’Ovidio Fabio Savini James Rudge Ugo de Grazia |
| author_sort | Annachiara D’Urso |
| collection | DOAJ |
| description | Therapeutic drug monitoring (TDM) of antiseizure medications (ASMs) represents a valuable tool to establish an appropriate patient therapy, to collect important information about drugs’ interactions and to evaluate patient’s metabolic capabilities. In recent years, a new volumetric absorptive microsampling technique using VAMS<sup>®</sup> technology and Mitra<sup>®</sup> devices, consisting of a sampling technique for the collection of fixed-volume capillary blood, was developed. These new devices provide a new home-sampling technique for whole blood that has been spread out to simplify sample collection from finger-pricks. This review is aimed to compare published articles concerning the application of VAMS<sup>®</sup> in epilepsy and to identify the strengths and improvement points for the TDM of antiseizure medications. VAMS<sup>®</sup> allowed a minimally invasive blood sampling even in the absence of trained personnel. Good stability data have indicated that storage and delivery can be facilitated only for specific ASMs. Trueness and precision parameters have been evaluated, and the hematocrit (HCT) effect was minimized. |
| first_indexed | 2024-03-10T09:58:57Z |
| format | Article |
| id | doaj.art-abdd41415e174851917e5675ec603846 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T09:58:57Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-abdd41415e174851917e5675ec6038462023-11-22T02:08:15ZengMDPI AGPharmaceuticals1424-82472021-06-0114762710.3390/ph14070627Therapeutic Drug Monitoring of Antiseizure Medications Using Volumetric Absorptive Microsampling: Where Are We?Annachiara D’Urso0Marcello Locatelli1Angela Tartaglia2Linda Molteni3Cristian D’Ovidio4Fabio Savini5James Rudge6Ugo de Grazia7Laboratory of Neurological Biochemistry and Neuropharmacology, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milano, ItalyDepartment of Pharmacy, University “G. d’Annunzio” of Chieti-Pescara, 66100 Chieti, ItalyDepartment of Pharmacy, University “G. d’Annunzio” of Chieti-Pescara, 66100 Chieti, ItalyLaboratory of Neurological Biochemistry and Neuropharmacology, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milano, ItalySection of Legal Medicine, Center for Advanced Studies and Technology (CAST), Department of Medicine and Aging Sciences, University “G. d’Annunzio” of Chieti-Pescara, 66100 Chieti, ItalyPharmatoxicology Laboratory, Hospital “Santo Spirito”, Via Fonte Romana 8, 65124 Pescara, ItalyNeoteryx LLC, Torrance, 90501 CA, USALaboratory of Neurological Biochemistry and Neuropharmacology, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milano, ItalyTherapeutic drug monitoring (TDM) of antiseizure medications (ASMs) represents a valuable tool to establish an appropriate patient therapy, to collect important information about drugs’ interactions and to evaluate patient’s metabolic capabilities. In recent years, a new volumetric absorptive microsampling technique using VAMS<sup>®</sup> technology and Mitra<sup>®</sup> devices, consisting of a sampling technique for the collection of fixed-volume capillary blood, was developed. These new devices provide a new home-sampling technique for whole blood that has been spread out to simplify sample collection from finger-pricks. This review is aimed to compare published articles concerning the application of VAMS<sup>®</sup> in epilepsy and to identify the strengths and improvement points for the TDM of antiseizure medications. VAMS<sup>®</sup> allowed a minimally invasive blood sampling even in the absence of trained personnel. Good stability data have indicated that storage and delivery can be facilitated only for specific ASMs. Trueness and precision parameters have been evaluated, and the hematocrit (HCT) effect was minimized.https://www.mdpi.com/1424-8247/14/7/627volumetric absorptive microsamplingtherapeutic drug monitoringbioanalysiswhole blood analysisantiseizure medicationsblood-to-plasma ratio |
| spellingShingle | Annachiara D’Urso Marcello Locatelli Angela Tartaglia Linda Molteni Cristian D’Ovidio Fabio Savini James Rudge Ugo de Grazia Therapeutic Drug Monitoring of Antiseizure Medications Using Volumetric Absorptive Microsampling: Where Are We? Pharmaceuticals volumetric absorptive microsampling therapeutic drug monitoring bioanalysis whole blood analysis antiseizure medications blood-to-plasma ratio |
| title | Therapeutic Drug Monitoring of Antiseizure Medications Using Volumetric Absorptive Microsampling: Where Are We? |
| title_full | Therapeutic Drug Monitoring of Antiseizure Medications Using Volumetric Absorptive Microsampling: Where Are We? |
| title_fullStr | Therapeutic Drug Monitoring of Antiseizure Medications Using Volumetric Absorptive Microsampling: Where Are We? |
| title_full_unstemmed | Therapeutic Drug Monitoring of Antiseizure Medications Using Volumetric Absorptive Microsampling: Where Are We? |
| title_short | Therapeutic Drug Monitoring of Antiseizure Medications Using Volumetric Absorptive Microsampling: Where Are We? |
| title_sort | therapeutic drug monitoring of antiseizure medications using volumetric absorptive microsampling where are we |
| topic | volumetric absorptive microsampling therapeutic drug monitoring bioanalysis whole blood analysis antiseizure medications blood-to-plasma ratio |
| url | https://www.mdpi.com/1424-8247/14/7/627 |
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