Serum neurofilament light chain levels in migraine patients: a monocentric case–control study in China
Abstract Purpose Serum neurofilament light chain (sNfL) can reflect nerve damage. Whether migraine can cause neurological damage remain unclear. This study assesses sNfL levels in migraine patients and explores whether there is nerve damage in migraine. Methods A case–control study was conducted in...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | The Journal of Headache and Pain |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s10194-023-01674-2 |
| _version_ | 1797630123264966656 |
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| author | Jie Fang Jielong Wu Tengkun Zhang Xiaodong Yuan Jiedong Zhao Liangcheng Zheng Ganji Hong Lu Yu Qing Lin Xingkai An Chuya Jing Qiuhong Zhang Chen Wang Zhanxiang Wang Qilin Ma |
| author_facet | Jie Fang Jielong Wu Tengkun Zhang Xiaodong Yuan Jiedong Zhao Liangcheng Zheng Ganji Hong Lu Yu Qing Lin Xingkai An Chuya Jing Qiuhong Zhang Chen Wang Zhanxiang Wang Qilin Ma |
| author_sort | Jie Fang |
| collection | DOAJ |
| description | Abstract Purpose Serum neurofilament light chain (sNfL) can reflect nerve damage. Whether migraine can cause neurological damage remain unclear. This study assesses sNfL levels in migraine patients and explores whether there is nerve damage in migraine. Methods A case–control study was conducted in Xiamen, China. A total of 138 migraine patients and 70 healthy controls were recruited. sNfL (pg/mL) was measured on the single-molecule array platform. Univariate, Pearson correlation and linear regression analysis were used to assess the relationship between migraine and sNfL levels, with further subgroup analysis by migraine characteristics. Results Overall, 85.10% of the 208 subjects were female, with a median age of 36 years. sNfL levels were higher in the migraine group than in the control group (4.85 (3.49, 6.62) vs. 4.11 (3.22, 5.59)), but the difference was not significant (P = 0.133). The two groups showed an almost consistent trend in which sNfL levels increased significantly with age. Subgroup analysis showed a significant increase in sNfL levels in patients with a migraine course ≥ 10 years (β = 0.693 (0.168, 1.220), P = 0.010). Regression analysis results show that age and migraine course are independent risk factors for elevated sNfL levels, and there is an interaction between the two factors. Patients aged < 45 years and with a migraine course ≥ 10 years have significantly increased sNfL levels. Conclusions This is the first study to evaluate sNfL levels in migraine patients. The sNfL levels significantly increased in patients with a migraine course ≥ 10 years. More attention to nerve damage in young patients with a long course of migraine is required. |
| first_indexed | 2024-03-11T11:02:27Z |
| format | Article |
| id | doaj.art-abdec2402243405b8e7ea24e7cf94023 |
| institution | Directory Open Access Journal |
| issn | 1129-2377 |
| language | English |
| last_indexed | 2024-03-11T11:02:27Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | The Journal of Headache and Pain |
| spelling | doaj.art-abdec2402243405b8e7ea24e7cf940232023-11-12T12:24:53ZengBMCThe Journal of Headache and Pain1129-23772023-11-012411910.1186/s10194-023-01674-2Serum neurofilament light chain levels in migraine patients: a monocentric case–control study in ChinaJie Fang0Jielong Wu1Tengkun Zhang2Xiaodong Yuan3Jiedong Zhao4Liangcheng Zheng5Ganji Hong6Lu Yu7Qing Lin8Xingkai An9Chuya Jing10Qiuhong Zhang11Chen Wang12Zhanxiang Wang13Qilin Ma14Department of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Neurology, The Fifth Hospital of XiamenDepartment of Gynecology, Xiamen Maternal and Child Health Care HospitalThe School of Clinical Medicine, Fujian Medical UniversityDepartment of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityCerebrovascular Interventional Department, Zhangzhou Hospital of Fujian ProvinceDepartment of Neurology, Changxing People’s HospitalDepartment of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityDepartment of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityThe School of Clinical Medicine, Fujian Medical UniversityDepartment of Neurology and Department of Neuroscience, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen UniversityAbstract Purpose Serum neurofilament light chain (sNfL) can reflect nerve damage. Whether migraine can cause neurological damage remain unclear. This study assesses sNfL levels in migraine patients and explores whether there is nerve damage in migraine. Methods A case–control study was conducted in Xiamen, China. A total of 138 migraine patients and 70 healthy controls were recruited. sNfL (pg/mL) was measured on the single-molecule array platform. Univariate, Pearson correlation and linear regression analysis were used to assess the relationship between migraine and sNfL levels, with further subgroup analysis by migraine characteristics. Results Overall, 85.10% of the 208 subjects were female, with a median age of 36 years. sNfL levels were higher in the migraine group than in the control group (4.85 (3.49, 6.62) vs. 4.11 (3.22, 5.59)), but the difference was not significant (P = 0.133). The two groups showed an almost consistent trend in which sNfL levels increased significantly with age. Subgroup analysis showed a significant increase in sNfL levels in patients with a migraine course ≥ 10 years (β = 0.693 (0.168, 1.220), P = 0.010). Regression analysis results show that age and migraine course are independent risk factors for elevated sNfL levels, and there is an interaction between the two factors. Patients aged < 45 years and with a migraine course ≥ 10 years have significantly increased sNfL levels. Conclusions This is the first study to evaluate sNfL levels in migraine patients. The sNfL levels significantly increased in patients with a migraine course ≥ 10 years. More attention to nerve damage in young patients with a long course of migraine is required.https://doi.org/10.1186/s10194-023-01674-2Serum neurofilament light chainMigraineMigraine disease courseNeurological damage |
| spellingShingle | Jie Fang Jielong Wu Tengkun Zhang Xiaodong Yuan Jiedong Zhao Liangcheng Zheng Ganji Hong Lu Yu Qing Lin Xingkai An Chuya Jing Qiuhong Zhang Chen Wang Zhanxiang Wang Qilin Ma Serum neurofilament light chain levels in migraine patients: a monocentric case–control study in China The Journal of Headache and Pain Serum neurofilament light chain Migraine Migraine disease course Neurological damage |
| title | Serum neurofilament light chain levels in migraine patients: a monocentric case–control study in China |
| title_full | Serum neurofilament light chain levels in migraine patients: a monocentric case–control study in China |
| title_fullStr | Serum neurofilament light chain levels in migraine patients: a monocentric case–control study in China |
| title_full_unstemmed | Serum neurofilament light chain levels in migraine patients: a monocentric case–control study in China |
| title_short | Serum neurofilament light chain levels in migraine patients: a monocentric case–control study in China |
| title_sort | serum neurofilament light chain levels in migraine patients a monocentric case control study in china |
| topic | Serum neurofilament light chain Migraine Migraine disease course Neurological damage |
| url | https://doi.org/10.1186/s10194-023-01674-2 |
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